The impact of therapeutic hypothermia on neurological function and quality of life after cardiac arrest

Bro-Jeppesen, John; Kjærgaard, Jesper; Horsted, Tina I.; Wanscher, Michael; Nielsen, Søren; Rasmussen, Lars S.; Hassager, Christian

doi:10.1016/j.resuscitation.2008.09.009

Cited by 116 publications

(71 citation statements)

References 20 publications

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“…11,[22][23][24][25][26] Only one study with historical controls reported better neurological outcome after VF cardiac arrest but no difference in outcome after cardiac arrest associated with other rhythms. 27 Two nonrandomized studies with concurrent controls 28,29 indicate a possible benefit of hypothermia after in-and out-of-hospital cardiac arrest associated with non-VF initial rhythms.…”

Section: Targeted Temperature Management Induced Hypothermiamentioning

confidence: 99%

Part 9: Post–Cardiac Arrest Care

Peberdy¹,

Callaway²,

Neumar³

et al. 2010

Circulation

1,459

838

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Section: Targeted Temperature Management Induced Hypothermiamentioning

confidence: 99%

Part 9: Post–Cardiac Arrest Care

Peberdy¹,

Callaway²,

Neumar³

et al. 2010

Circulation

1,459

838

View full text Add to dashboard Cite

“…7,8,10,13,14,43,44 Among the strengths of the present study are the high inclusion ratio and the fact that we were able to obtain information on patients who chose not to participate in the study but consented to the main trial. These data were used to perform multiple imputations.…”

Section: Discussionmentioning

confidence: 99%

Cognitive Function in Survivors of Out-of-Hospital Cardiac Arrest After Target Temperature Management at 33°C Versus 36°C

et al. 2015

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Background— Target temperature management is recommended as a neuroprotective strategy after out-of-hospital cardiac arrest. Potential effects of different target temperatures on cognitive impairment commonly described in survivors have not been investigated sufficiently. The primary aim of this study was to evaluate whether a target temperature of 33°C compared with 36°C was favorable for cognitive function; the secondary aim was to describe cognitive impairment in cardiac arrest survivors in general. Methods and Results— Study sites included 652 cardiac arrest survivors originally randomized and stratified for site to temperature control at 33°C or 36°C within the Target Temperature Management trial. Survival until 180 days after the arrest was 52% (33°C, n=178/328; 36°C, n=164/324). Survivors were invited to a face-to-face follow-up, and 287 cardiac arrest survivors (33°C, n=148/36°C, n=139) were assessed with tests for memory (Rivermead Behavioural Memory Test), executive functions (Frontal Assessment Battery), and attention/mental speed (Symbol Digit Modalities Test). A control group of 119 matched patients hospitalized for acute ST-segment–elevation myocardial infarction without cardiac arrest performed the same assessments. Half of the cardiac arrest survivors had cognitive impairment, which was mostly mild. Cognitive outcome did not differ ( P >0.30) between the 2 temperature groups (33°C/36°C). Compared with control subjects with ST-segment–elevation myocardial infarction, attention/mental speed was more affected among cardiac arrest patients, but results for memory and executive functioning were similar. Conclusions— Cognitive function was comparable in survivors of out-of-hospital cardiac arrest when a temperature of 33°C and 36°C was targeted. Cognitive impairment detected in cardiac arrest survivors was also common in matched control subjects with ST-segment–elevation myocardial infarction not having had a cardiac arrest. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT01946932.

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“…749,828 -832 One study with historical controls showed better neurological outcome after VF cardiac arrest but no difference after cardiac arrest from other rhythms (LOE 3). 833 Two nonrandomized studies with concurrent controls indicated possible benefit of hypothermia following cardiac arrest from other initial rhythms in-and out-ofhospital (LOE 2). 834,835 One registry study, which included almost 1000 cooled comatose patients following cardiac arrest from all rhythms, showed that survival with good outcome at 6 months was 56% after initial VT/VF, 21% after initial asystole, and 23% after initial PEA (LOE 4).…”

Section: Consensus On Sciencementioning

confidence: 99%

“…(See also Implementing Therapeutic Hypothermia in Section 12). Nineteen studies indicated that cooling could be initiated safely with IV ice-cold fluids (30 mL/kg of saline 0.9% or Ringer's lactate) (LOE 3 748,749,825,831,833,837 ; LOE 4 779,780,782-785,810,836,838 -843 ). Six studies indicated that cooling with IV cold saline can be initiated in the prehospital phase (LOE 1 781,844 ; LOE 2 845 ; LOE 3 261,846 748,841,850,[853][854][855].…”

Section: Consensus On Sciencementioning

confidence: 99%