2023
DOI: 10.3390/medicina59050867
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The Impact of Therapeutic Plasma Exchange on Inflammatory Markers and Acute Phase Reactants in Patients with Severe SARS-CoV-2 Infection

Abstract: Background and Objectives: Due to the poor prognosis and the very high mortality rate associated with severe SARS-CoV-2 infections, various regimens have been tried to stop the evolution of the inflammatory cascade, such as immunomodulatory therapy and plasma clearance of the acute phase reactants involved. Therefore, the objective of this review was to analyze the effects of using therapeutic plasma exchange (TPE), also known as plasmapheresis, on the inflammatory markers of critically ill COVID-19 patients a… Show more

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Cited by 6 publications
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“…We excluded patients with chemotherapy or radiotherapy before the surgery because their effects on systemic inflammation (either increased or decreased) were observed for months after treatment, and Zou et al mentioned that adjuvant chemotherapy appeared to be more effective in patients with CRC with high NLR or PLR [ 9 , 10 , 11 ]. Similarly, SARS-CoV-2 infection is associated with a systemic inflammatory response, besides the inflammation associated with the presence of colorectal cancer [ 12 ]; in other words, patients with a history of this infection prior to the intervention or patients who developed an infection during the hospital stay were excluded.…”
Section: Methodsmentioning
confidence: 99%
“…We excluded patients with chemotherapy or radiotherapy before the surgery because their effects on systemic inflammation (either increased or decreased) were observed for months after treatment, and Zou et al mentioned that adjuvant chemotherapy appeared to be more effective in patients with CRC with high NLR or PLR [ 9 , 10 , 11 ]. Similarly, SARS-CoV-2 infection is associated with a systemic inflammatory response, besides the inflammation associated with the presence of colorectal cancer [ 12 ]; in other words, patients with a history of this infection prior to the intervention or patients who developed an infection during the hospital stay were excluded.…”
Section: Methodsmentioning
confidence: 99%
“…Inclusion and exclusion criteria were established for the study. Patients with a history of prior SARS CoV-2 infection or who developed infection during hospitalization were excluded due to the strong inflammatory response associated with the virus [13][14][15]. Additionally, as neoadjuvant chemotherapy and radiotherapy significantly impact the inflammatory system, patients who underwent these treatments were excluded based on studies indicating, for example, that a lower Systemic Immune-Inflammation Index (SII) is a positive prognostic factor in this context [16,17].…”
Section: Methodsmentioning
confidence: 99%