The impact of tics, obsessive–compulsive symptoms, and impulsivity on global functioning in Tourette syndrome

Kano, Yukiko; Kono, Toshiaki; Matsuda, Natsumi; Nonaka, Michio; Kuwabara, Hitoshi; Shimada, Takafumi; Shishikura, Kurie; Konno, Chizue; Ohta, Mitsuaki

doi:10.1016/j.psychres.2014.12.041

Cited by 18 publications

(10 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6 In another study investigating the relationship between tics, obsessive compulsive symptoms (OCSs), and impulsivity, and their effects on global functioning in children and adult patients with TS, the impact of OCSs on global functioning was greater than that of tics in children, despite a moderate correlation between tic severity and OCSs. 21 Similarly, in a cross-sectional study of children evaluated at two TS clinics, using a multiple linear regression model, including diagnosis, age, sex, and TS, OCD, and ADHD symptom severity, it was concluded that the most significant predictor of the psychosocial summary score was ADHD symptom severity. 11 Children with both TS and ADHD compared to those with TS alone had significantly more behavioral problems, poorer social adaptation, and worse QOL.…”

Section: Studies Supporting Tics As the Main Source Of Disability In Tsmentioning

confidence: 99%

“…For the adult group, global functioning scores were significantly and negatively correlated with only the YGTSS global severity scores (r520.515, p50.020). 21 Traditionally, TS has been viewed as a disease that is more common in men, thus women have always been under-represented in research. However, a large international sample with 3,500 individuals with TS (69% from North American samples) found that among adult patients the male preponderance was less pronounced.…”

Section: Tic Progression Into Adulthoodmentioning

confidence: 99%

See 1 more Smart Citation

Sources of Disability in Tourette Syndrome: Children vs. Adults

Kompoliti

2016

Tremor and Other Hyperkinetic Movements

View full text Add to dashboard Cite

Background: Tourette syndrome (TS) is a neurodevelopmental disorder characterized by tics and neuropsychiatric co-morbidities like Obsessive Compulsive Disorder (OCD) and Attention Deficit Disorder (ADHD), among others. In many instances tics get better with age but this is not always true regarding the psychiatric co-morbidities. Methods: This manuscript reviews the disease-specific Quality of Life (QOL) instruments used to measure disability in TS and the existing literature on sources of functional impairment in children and adults with TS. Results: Traditionally, disability in TS has been recorded using objective measures. In recent years there has been a development of disease-specific instruments to measure subjectively the impact of the different aspects of TS on the patient's daily function. The differential impact of tics vs. the psychiatric co-morbidities in children with TS is an issue of debate in the existing literature. In adults with TS, the literature is scant, therefore the sources of disability in this group are even less defined compared to children. Discussion: As clinicians, we need to focus on determining the sources of disability in children and adults with TS so we can target our interventions successfully.

show abstract

Section: Studies Supporting Tics As the Main Source Of Disability In Tsmentioning

confidence: 99%

Section: Tic Progression Into Adulthoodmentioning

confidence: 99%

Sources of Disability in Tourette Syndrome: Children vs. Adults

Kompoliti

2016

Tremor and Other Hyperkinetic Movements

View full text Add to dashboard Cite

show abstract

“…Tic severity in children has been found to be a predictor of poor outcome on physical, psychological and cognitive domains of QoL later in life . Especially, comorbidity with OC symptoms has shown to be an aggravating factor and leads to decreased global functioning, lower self‐esteem and difficulties in relationships as well as a negative influence on vitality, bodily pain, general health perceptions, physical role functioning, emotional role functioning, social role functioning, and mental health …”

Section: Introductionmentioning

confidence: 99%

Effects of comorbidity on Tourette's tic severity and quality of life

et al. 2019

View full text Add to dashboard Cite

ObjectiveThe aim of this study is to gain more insight in the differential contributions of anxiety, depression and obsessive‐compulsive (OC) symptom severity to quality of life (QoL) and tic severity in adults with Tourette Disorder (TD).MethodsSelf‐reported OC symptom, anxiety and depression severity measures were used to investigate their predictive value on QoL and Tic severity in adult TD patients (N = 187), using correlation, regression, and mediation analyses.ResultsTic severity has no effect on QoL. Depression severity directly reduces QoL, whereas anxiety and OC symptom severity have an indirect effect on QoL, mediated by depression severity. OC symptom severity directly affects tic severity, whereas depression and anxiety severity do not have a direct effect on tic or OC severity. Finally, anxiety severity indirectly impacts tic severity, with OC symptom severity functioning as a mediator.ConclusionIn line with and extending previous studies, these findings indicate that OC symptom severity directly influences tic symptom severity whereas depression severity directly influences QoL in TD. Results imply that to improve QoL in TD patients, treatment should primarily focus on diminishing OC and depressive symptom severity rather than focusing on tic reduction.

show abstract

“…Psychological experiences of frustration may generate anger and aggressive behaviors (Pawliczek et al, 2013). Aggression and conduct disorder has been frequently associated with TS (Comings and Comings, 1987; Wand et al, 1993; Dehning et al, 2015; Kano et al, 2015). …”

Section: Contextual and Emotional Triggers As Exacerbating Factorsmentioning

confidence: 99%

What makes you tic? Translational approaches to study the role of stress and contextual triggers in Tourette syndrome

Godar¹,

Bortolato

2017

Neuroscience & Biobehavioral Reviews

View full text Add to dashboard Cite

Tourette syndrome (TS) is a neurodevelopmental condition characterized by multiple, recurring motor and phonic tics. Rich empirical evidence shows that the severity of tics and associated manifestations is increased by several stressors and contextual triggers; however, the neurobiological mechanisms responsible for symptom exacerbation in TS remain poorly understood. This conceptual gap partially reflects the high phenotypic variability in tics, as well as the existing difficulties in operationalizing and standardizing stress and its effects in a clinical setting. Animal models of TS may be highly informative tools to overcome some of these limitations; these experimental preparations have already provided critical insights on key aspects of TS pathophysiology, and may prove useful to identify the neurochemical alterations induced by different stressful contingencies. In particular, emerging knowledge on the role of contextual triggers in animal models of TS may inform the development of novel pharmacological interventions to reduce tic fluctuations in this disorder.

show abstract

The impact of tics, obsessive–compulsive symptoms, and impulsivity on global functioning in Tourette syndrome

Cited by 18 publications

References 23 publications

Sources of Disability in Tourette Syndrome: Children vs. Adults

Sources of Disability in Tourette Syndrome: Children vs. Adults

Effects of comorbidity on Tourette's tic severity and quality of life

What makes you tic? Translational approaches to study the role of stress and contextual triggers in Tourette syndrome

Contact Info

Product

Resources

About