The impact of tobacco exposure on tumor microenvironment and prognosis in lung adenocarcinoma by integrative analysis of multi-omics data

Lü, Xiaomin; Ma, Liang; Yin, Xuewen; Ji, Hong; Qian, Yue; Zhong, Sixun; Yan, Aiting; Zhang, Yan

doi:10.1016/j.intimp.2021.108253

Cited by 3 publications

(4 citation statements)

References 6 publications

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“…Meanwhile, smoking and alcohol consumption are well-known risk factors for lung cancer [ 15 , 19 ]. Vitamin B 6 may be associated with smoking-induced inflammation and immune activation, which was also one of the mechanisms related to smoking in lung cancer development [ 30 , 57 , 58 ].…”

Section: Discussionmentioning

confidence: 99%

“…Based on previous experience and studies [ 18 , 23 , 27 , 30 ], clinical characteristics were evaluated as potential confounders of the association between serum vitamin levels and intrapulmonary metastasis status, including age, sex, BMI, family history of cancer, smoking history, alcohol consumption, the season of blood collection for vitamin testing, educational level, and tumor type (pathology, diameter, number, and density).…”

Section: Methodsmentioning

confidence: 99%

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Positive Association of Serum Vitamin B6 Levels with Intrapulmonary Lymph Node and/or Localized Pleural Metastases in Non-Small Cell Lung Cancer: A Retrospective Study

Liu

Bai

et al. 2023

Nutrients

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The relationship between vitamin B levels and the development and progression of lung cancer remains inconclusive. We aimed to investigate the relationship between B vitamins and intrapulmonary lymph nodes as well as localized pleural metastases in patients with non-small cell lung cancer (NSCLC). This was a retrospective study including patients who underwent lung surgery for suspected NSCLC at our institution from January 2016 to December 2018. Logistic regression models were used to evaluate the associations between serum B vitamin levels and intrapulmonary lymph node and/or localized pleural metastases. Stratified analysis was performed according to different clinical characteristics and tumor types. A total of 1498 patients were included in the analyses. Serum vitamin B6 levels showed a positive association with intrapulmonary metastasis in a multivariate logistic regression (odds ratio (OR) of 1.016, 95% confidence interval (CI) of 1.002–1.031, p = 0.021). After multivariable adjustment, we found a high risk of intrapulmonary metastasis in patients with high serum vitamin B6 levels (fourth quartile (Q4) vs. Q1, OR of 1.676, 95%CI of 1.092 to 2.574, p = 0.018, p for trend of 0.030). Stratified analyses showed that the positive association between serum vitamin B6 and lymph node metastasis appeared to be stronger in females, current smokers, current drinkers, and those with a family history of cancer, squamous cell carcinoma, a tumor of 1–3 cm in diameter, or a solitary tumor. Even though serum vitamin B6 levels were associated with preoperative NSCLC upstaging, B6 did not qualify as a useful biomarker due to weak association and wide confidence intervals. Thus, it would be appropriate to prospectively investigate the relationship between serum vitamin B6 levels and lung cancer further.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Positive Association of Serum Vitamin B6 Levels with Intrapulmonary Lymph Node and/or Localized Pleural Metastases in Non-Small Cell Lung Cancer: A Retrospective Study

Liu

Bai

et al. 2023

Nutrients

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“…Exposure to cigarette smoke remodels the B cell repertoire not only in the TME but also in circulation. Exposure to tobacco smoke in vitro affects the evolution of the immune milieu in the LUAD TME (65,66). Enrichment of differentiated memory B cell populations correlates with poor prognosis in tobacco-exposed LUAD (65).…”

Section: Discussionmentioning

confidence: 99%

“…Exposure to tobacco smoke in vitro affects the evolution of the immune milieu in the LUAD TME (65,66). Enrichment of differentiated memory B cell populations correlates with poor prognosis in tobacco-exposed LUAD (65). Significantly higher levels of class-switched memory B cells have been observed in the blood of current smokers (67).…”

Section: Discussionmentioning

confidence: 99%

Deep immune B and plasma cell repertoire in non-small cell lung cancer

et al. 2023

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IntroductionB cells, which have long been thought to be minor players in the development of anti-tumor responses, have been implicated as key players in lung cancer pathogenesis and response to checkpoint blockade in patients with lung cancer. Enrichment of late-stage plasma and memory cells in the tumor microenvironment has been shown in lung cancer, with the plasma cell repertoire existing on a functional spectrum with suppressive phenotypes correlating with outcome. B cell dynamics may be influenced by the inflammatory microenvironment observed in smokers and between LUAD and LUSC.MethodsHere, we show through high-dimensional deep phenotyping using mass cytometry (CyTOF), next generation RNA sequencing and multispectral immunofluorescence imaging (VECTRA Polaris) that key differences exist in the B cell repertoire between tumor and circulation in paired specimens from lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC).ResultsIn addition to the current literature, this study provides insight into the in-depth description of the B cell contexture in Non-Small Cell Lung Cancer (NSCLC) with reference to broad clinico-pathological parameters based on our analysis of 56 patients. Our findings reinforce the phenomenon of B-cell trafficking from distant circulatory compartments into the tumour microenvironment (TME). The circulatory repertoire shows a predilection toward plasma and memory phenotypes in LUAD however no major differences exist between LUAD and LUSC at the level of the TME. B cell repertoire, amongst other factors, may be influenced by the inflammatory burden in the TME and circulation, that is, smokers and non-smokers. We have further clearly demonstrated that the plasma cell repertoire exists on a functional spectrum in lung cancer, and that the suppressive regulatory arm of this axis may play a significant role in determining postoperative outcomes as well as following checkpoint blockade. This will require further long-term functional correlation.ConclusionB and Plasma cell repertoire is very diverse and heterogeneous across different tissue compartments in lung cancer. Smoking status associates with key differences in the immune milieu and the consequent inflammatory microenvironment is likely responsible for the functional and phenotypic spectrum we have seen in the plasma cell and B cell repertoire in this condition.

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Serum metabolome perturbation in relation to noise exposure: Exploring the potential role of serum metabolites in noise-induced arterial stiffness

Chen,

Li,

Zhang

et al. 2024

Environmental Pollution

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The impact of tobacco exposure on tumor microenvironment and prognosis in lung adenocarcinoma by integrative analysis of multi-omics data

Cited by 3 publications

References 6 publications

Positive Association of Serum Vitamin B6 Levels with Intrapulmonary Lymph Node and/or Localized Pleural Metastases in Non-Small Cell Lung Cancer: A Retrospective Study

Positive Association of Serum Vitamin B6 Levels with Intrapulmonary Lymph Node and/or Localized Pleural Metastases in Non-Small Cell Lung Cancer: A Retrospective Study

Deep immune B and plasma cell repertoire in non-small cell lung cancer

Serum metabolome perturbation in relation to noise exposure: Exploring the potential role of serum metabolites in noise-induced arterial stiffness

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