The impact of tobacco smoking on treatment choice and efficacy in inflammatory bowel disease

Nicolaides, Steven; Vasudevan, Abhinav; Long, Tony; Langenberg, Daniel R. van

doi:10.5217/ir.2020.00008

Cited by 16 publications

(8 citation statements)

References 100 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found that the effect of smoking on the CD using the logistic regression model remained significant with an odds ratio ( OR ) of 2.319 (95% CI: 1.603, 3.485, p < 0.001), adjusting for sex, age, CD8 + T cells, CD4 + T cells, NK cells, B cells, monocytes, and granulocytes ( Table 2 ). The results suggested that smoking accelerated CD progression, which was consistent with previous reports ( Nicolaides et al, 2021 ; van der Sloot et al, 2021 ).…”

Section: Resultssupporting

confidence: 93%

“…Methylation marks are often considered potential mediators between exposures and outcomes. Numerous studies have established a clear relationship between smoking and the occurrence of IBD and its significantly detrimental effects on CD, whereas the opposite is the beneficial influence of the development of UC ( Tanja Birrenbach MUBM, 2004 ; Khasawneh et al, 2017 ; Nicolaides et al, 2021 ; van der Sloot et al, 2021 ). What is less clear is whether smoking impacts the biological mechanism in CD by mediating DNA methylation.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that the relationship between smoking and IBD is complex and remains the most independent and prominent risk factor. It is well established that smoking has significant detrimental effects on the course of CD, but it has a beneficial influence on the development of UC ( Tanja Birrenbach MUBM, 2004 ; Khasawneh et al, 2017 ; Nicolaides et al, 2021 ; van der Sloot et al, 2021 ). However, the efficacy of smoking on IBD remains largely unknown.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

High-Dimensional DNA Methylation Mediates the Effect of Smoking on Crohn’s Disease

Wang

Xia

2022

Front. Genet.

View full text Add to dashboard Cite

Epigenome-wide mediation analysis aims to identify high-dimensional DNA methylation at cytosine–phosphate–guanine (CpG) sites that mediate the causal effect of linking smoking with Crohn’s disease (CD) outcome. Studies have shown that smoking has significant detrimental effects on the course of CD. So we assessed whether DNA methylation mediates the association between smoking and CD. Among 103 CD cases and 174 controls, we estimated whether the effects of smoking on CD are mediated through DNA methylation CpG sites, which we referred to as causal mediation effect. Based on the causal diagram, we first implemented sure independence screening (SIS) to reduce the pool of potential mediator CpGs from a very large to a moderate number; then, we implemented variable selection with de-sparsifying the LASSO regression. Finally, we carried out a comprehensive mediation analysis and conducted sensitivity analysis, which was adjusted for potential confounders of age, sex, and blood cell type proportions to estimate the mediation effects. Smoking was significantly associated with CD under odds ratio (OR) of 2.319 (95% CI: 1.603, 3.485, p < 0.001) after adjustment for confounders. Ninety-nine mediator CpGs were selected from SIS, and then, seven candidate CpGs were obtained by de-sparsifying the LASSO regression. Four of these CpGs showed statistical significance, and the average causal mediation effects (ACME) were attenuated from 0.066 to 0.126. Notably, three significant mediator CpGs had absolute sensitivity parameters of 0.40, indicating that these mediation effects were robust even when the assumptions were slightly violated. Genes (BCL3 and FKBP5) harboring these four CpGs were related to CD. These findings suggest that changes in methylation are involved in the mechanism by which smoking increases risk of CD.

show abstract

Section: Resultssupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

High-Dimensional DNA Methylation Mediates the Effect of Smoking on Crohn’s Disease

Wang

Xia

2022

Front. Genet.

View full text Add to dashboard Cite

show abstract

“…This increase is closely related to technological advances, improvements in health care and sanitation, increased energy utilization, modern transportation, changes in diet, and urbanization [17]. Smoking increases the risk of CD but is believed to reduce the severity of UC [59]. Smoking is associated with alterations in thiopurine metabolism and is considered to shorten the time to disease recurrence.…”

Section: Environmental Factorsmentioning

confidence: 99%

Inflammatory bowel disease in Korea: epidemiology and pathophysiology

Lee

Eun

2022

Korean J Intern Med

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD) refers to a group of disorders, including Crohn's disease and ulcerative colitis, that exhibit similar but distinct manifestations. These diseases are characterized by refractory and chronic inflammation of the bowel. IBD is usually accompanied by severe symptoms. When a patient presents with suspected IBD, physicians encounter various challenges in terms of diagnosis and treatment. In addition, given such characteristics, the associated medical expenses gradually increase. Although IBD was formerly known as a disease of Western countries, the incidence and prevalence are increasing in Korea. Korean investigators have accumulated a great deal of knowledge about the regional characteristics and epidemiology of the disease, especially via well-organized, joint cohort studies. Against this background, this article describes the epidemiology of IBD in Korea compared to that in the West. In addition, an overview of the pathophysiology of the disease is provided, focusing on the latest results.

show abstract

“…26 , 27 In contrast to previous reports, neither smoking nor family history of IBD were associated with worse outcomes in the present study ( P >.05). 28 Cigarette smoking is a culturally sensitive topic. It may have been underreported.…”

Section: Discussionmentioning

confidence: 99%

Clinical profile, course and outcomes of adults with inflammatory bowel disease over a decade: a single center experience

et al. 2022

View full text Add to dashboard Cite

BACKGROUND: Inflammatory bowel disease (IBD) is an important cause of morbidity in Saudi Arabia. OBJECTIVES: Determine the incidence, clinical profile, course and outcomes of IBD in Riyadh, Saudi Arabia. DESIGN: Medical record review SETTING: Tertiary care center PATIENTS AND METHODS: Data were extracted from the medical records of all patients with IBD admitted to King Abdulaziz Medical City, Riyadh, from 1 January 2009 to 31 December 2019. The complications of IBD were classified as gastrointestinal or extraintestinal. Comorbidities were classified as either systemic diseases or gastrointestinal diseases. MAIN OUTCOME MEASURES: Epidemiology, clinical manifestations and complications of IBD. SAMPLE SIZE AND CHARACTERISTICS: 435 patients with IBD, median (IQR) age at presentation 24.0 (14.0) years, 242 males (55.6%) RESULTS: The study population consisted of 249 patients with Crohn's disease (CD) (57.2%) and 186 with ulcerative colitis (UC) (42.8%). Nearly half were either overweight or obese. Abdominal pain, diarrhea and vomiting were the most common presenting symptoms. The most common extraintestinal manifestations were musculoskeletal (e.g., arthritis and arthralgia). Colorectal cancer was diagnosed in 3.2%. Patients with other gastrointestinal (GI) comorbidities were at higher risk of developing GI complications of IBD ( P ≤.05). Biological agents were used to treat 212 patients (87%) with CD and 102 patients (57%) with UC. CONCLUSIONS: The number of patients diagnosed with IBD and their body mass index increased each year over the period of interest. However, the rate of surgical intervention and number of serious complications fell. This improvement in outcomes was associated with a higher percentage of patients receiving biological therapy. LIMITATIONS: Incomplete data. Some patients diagnosed and/or followed up at other hospitals. CONFLICT OF INTEREST: None.

show abstract

The impact of tobacco smoking on treatment choice and efficacy in inflammatory bowel disease

Cited by 16 publications

References 100 publications

High-Dimensional DNA Methylation Mediates the Effect of Smoking on Crohn’s Disease

High-Dimensional DNA Methylation Mediates the Effect of Smoking on Crohn’s Disease

Inflammatory bowel disease in Korea: epidemiology and pathophysiology

Clinical profile, course and outcomes of adults with inflammatory bowel disease over a decade: a single center experience

Contact Info

Product

Resources

About