The impact of trauma on neutrophil function

Hazeldine, Jon; Hampson, Peter; Lord, Janet M.

doi:10.1016/j.injury.2014.06.021

Cited by 105 publications

(116 citation statements)

References 115 publications

Supporting

Mentioning

108

Contrasting

Unclassified

Order By: Relevance

“…A recent study compared the test characteristics of clinician suspicion with a derived clinical prediction rule to identify children at risk of intra-abdominal injuries undergoing acute intervention following blunt torso trauma [12]. This was a planned subanalysis of a prospective, multicenter observational study of children (< 18-years-old) with blunt torso trauma conducted in 20 EDs in the Pediatric Emergency Care Applied Research Network (PECARN) [12].…”

Section: Traumamentioning

confidence: 99%

“…This was a planned subanalysis of a prospective, multicenter observational study of children (< 18-years-old) with blunt torso trauma conducted in 20 EDs in the Pediatric Emergency Care Applied Research Network (PECARN) [12]. Clinicians documented their suspicion for the presence of intra-abdominal injuries needing acute intervention.…”

Section: Traumamentioning

confidence: 99%

“…The higher specificity of clinician suspicion, however, did not translate into clinical practice, as clinicians frequently obtained abdominal CT scans in patients they considered very low risk. If validated, this prediction rule can assist in clinical decision-making around abdominal CT use in children with blunt torso trauma [12].…”

Section: Traumamentioning

confidence: 99%

“…A well described consequence of traumatic injury is immune dysregulation, when an initial increase in immune activity is followed by a period of immune depression, leaving hospitalized trauma patients at an increased risk of nosocomial infections [12]. These authors discussed the emerging role of the neutrophil, the most abundant leukocyte in human circulation and the first line of defense against microbial challenge, in the initiation and propagation of the inflammatory response to trauma [12].…”

Section: Traumamentioning

confidence: 99%

See 3 more Smart Citations

Nursing Education, Trauma and Care in the Intensive Care

Frieri¹

2017

Int Arch Nurs Health Care

View full text Add to dashboard Cite

Section: Traumamentioning

confidence: 99%

Section: Traumamentioning

confidence: 99%

Section: Traumamentioning

confidence: 99%

Section: Traumamentioning

confidence: 99%

See 2 more Smart Citations

Nursing Education, Trauma and Care in the Intensive Care

Frieri¹

2017

Int Arch Nurs Health Care

View full text Add to dashboard Cite

“…The impact of trauma on neutrophil function was evaluated by Hazeldine 22 with trauma-induced changes in neutrophil biology linked to the development of such post-traumatic complications as multiple organ failure and acute respiratory distress syndrome, an area of research within the field of trauma immunology that is gaining considerable interest is the manipulation of neutrophil function as a means by which to potentially improve patient outcome (22).…”

Section: Role Of Neutrophilsmentioning

confidence: 99%

Biomarkers, Trauma, and Sepsis in Pediatrics: A Review

Frieri¹,

Kumar²,

Boutin³

2016

J Pediatr Rev

View full text Add to dashboard Cite

Context: There is a logical connection with biomarkers, trauma, and sepsis. This review paper provides new information and clinical practice implications. Biomarkers are very important especially in pediatrics. Procalcitonin and other biomarkers are helpful in identifying neonatal sepsis, defense mechanisms of the immune system. Pediatric trauma and sepsis is very important both in infants and in children. Stress management both in trauma is based upon the notion that stress causes an immune imbalance in susceptible individuals. Evidence Acquisition: Data sources included studies indexed in PubMed, a meta-analysis, predictive values, research strategies, and quality assessments. A recent paper by one of the authors stated marked increase in serum procalcitonin during the course of a septic process often indicates an exacerbation of the illness, and a decreasing level is a sign of improvement. A review of epidemiologic studies on pediatric soccer patients was also addressed. Keywords for searching included biomarkers, immunity, trauma, and sepsis. Results: Of 50 reviewed articles, 34 eligible articles were selected including biomarkers, predictive values for procalcitonin, identifying children at risk for intra-abdominal injuries, blunt trauma, and epidemiology, a meta-analysis. Of neonatal associated sepsis, the NF-kappa B pathway by inflammatory stimuli in human neutrophils, predictive value of gelsolin for the outcomes of preterm neonates, a metaanalysis interleukin-8 for neonatal sepsis diagnosis. Conclusions: Biomarkers are very important especially in pediatrics. Procalcitonin and other biomarkers are helpful in identifying neonatal sepsis, defense mechanisms, and physiological functions of the immune system. Pediatric trauma and sepsis is very important both in infants and in children. Various topics were covered such as biomarkers, trauma, sepsis, inflammation, innate immunity, role of neutrophils and IL-8, reactive oxygen species, neonatal hypoxia, NF-kappa B related to inflammation. These topics are clearly linked and are very important for pediatricians, pulmonologists, and immunologists in academic centers and in practice.

show abstract

Flow Cytometric Analysis of Hematopoietic Populations in Rat Bone Marrow. Impact of Trauma and Hemorrhagic Shock

et al. 2019

View full text Add to dashboard Cite

Severe injury and hemorrhagic shock (HS) result in multiple changes to hematopoietic differentiation, which contribute to the development of immunosuppression and multiple organ failure (MOF). Understanding the changes that take place during the acute injury phase may help predict which patients will develop MOF and provide potential targets for therapy. Obtaining bone marrow from humans during the acute injury phase is difficult so published data are largely derived from peripheral blood samples, which infer bone marrow changes that reflect the sustained inflammatory response. This preliminary and opportunistic study investigated leucopoietic changes in rat bone marrow 6 h following traumatic injury and HS. Terminally anesthetized male Porton Wistar rats were allocated randomly to receive a sham operation (cannulation with no injury) or femoral fracture and HS. Bone marrow cells were flushed from rat femurs and immunophenotypically stained with specific antibody panels for lymphoid (CD45R, CD127, CD90, and IgM) or myeloid (CD11b, CD45, and RP‐1) lineages. Subsequently, cell populations were fluorescence‐activated cell sorted for morphological assessment. Stage‐specific cell populations were identified using a limited number of antibodies, and leucopoietic changes were determined 6 h following trauma and HS. Myeloid subpopulations could be identified by varying levels CD11b expression, CD45, and RP‐1. Trauma and HS resulted in a significant reduction in total CD11b + myeloid cells including both immature (RP‐1(−)) and mature (RP‐1+) granulocytes. Multiple B‐cell lymphoid subsets were identified. The total percentage of CD90+ subsets remained unchanged following trauma and HS, but there was a reduction in the numbers of maturing CD90(−) cells suggesting movement into the periphery. © 2019 The Authors. Cytometry Part A published by Wiley Periodicals, Inc. on behalf of International Society for Advancement of Cytometry.

show abstract

The impact of trauma on neutrophil function

Cited by 105 publications

References 115 publications

Nursing Education, Trauma and Care in the Intensive Care

Nursing Education, Trauma and Care in the Intensive Care

Biomarkers, Trauma, and Sepsis in Pediatrics: A Review

Flow Cytometric Analysis of Hematopoietic Populations in Rat Bone Marrow. Impact of Trauma and Hemorrhagic Shock

Contact Info

Product

Resources

About