The impact of treatment on quality of life of patients with head and neck cancer and its association with prognosis

Carrillo, José F.; Carrillo, Liliana C.; Ramírez-Ortega, Margarita; Ochoa‐Carrillo, Francisco Javier; Oñate‐Ocaña, Luis F.

doi:10.1016/j.ejso.2016.05.037

Cited by 20 publications

(13 citation statements)

References 25 publications

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“…age at time of diagnosis, tumor stage, metastasis, and comorbidity) have impact on HRQOL. Additionally, HRQOL has prognostic value for survival in HNC cancer patients, independently from known predictors as sociodemographic and clinical parameters [39–52]. However, the association between HRQOL and survival is complex.…”

Section: Introductionmentioning

confidence: 99%

Advancing interdisciplinary research in head and neck cancer through a multicenter longitudinal prospective cohort study: the NETherlands QUality of life and BIomedical Cohort (NET-QUBIC) data warehouse and biobank

et al. 2019

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Background Worldwide, over 500,000 people are diagnosed with head and neck cancer each year, a disease with major impact on life expectancy and quality of life. The purpose of the Netherlands Quality of life and Biomedical Cohort study (NET-QUBIC) is to advance interdisciplinary research that aims to optimize diagnosis, treatment, and supportive care for head and neck cancer patients and their informal caregivers. Methods Using an extensive assessment protocol (electronic clinical record form, patient reported outcome measures and fieldwork (interviews and physical tests)), clinical data and data on quality of life, demographic and personal factors, psychosocial (depression, anxiety, fatigue, pain, sleep, mental adjustment to cancer, posttraumatic stress), physical (speech, swallowing, oral function, malnutrition, physical fitness, neurocognitive function, sexual function), lifestyle (physical activity, nutrition, smoking, alcohol, drugs), and social factors (social function, social support, work, health care use, and costs) are collected and stored in the data warehouse. A longitudinal biobank is built with tumor tissue, blood and blood components, saliva samples, and oral rinses. An infrastructure for fieldwork and laboratory protocols is established at all participating centers. All patients fill out patient reported outcome measures before treatment and at 3, 6, 12, 24, 36, 48, and 60 months follow-up. The interviews, physical tests and biological sample collection are at baseline and 6, 12, and 24 months follow-up. The protocol for caregivers includes blood sampling and oral rinses at baseline and a tailored list of questionnaires, administered at the same time points as the patients. In total, 739 HNC patients and 262 informal caregivers have been included in 5 out of the 8 HNC centers in the Netherlands. Discussion By granting access to researchers to the NET-QUBIC data warehouse and biobank, we enable new research lines in clinical (e.g. treatment optimization in elderly patients), biological (e.g. liquid biopsy analysis for relapse detection), health related quality of life (e.g. the impact of toxicity on quality of life), and interrelated research (e.g. health related quality of life in relation to biomarkers and survival).

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Section: Introductionmentioning

confidence: 99%

Advancing interdisciplinary research in head and neck cancer through a multicenter longitudinal prospective cohort study: the NETherlands QUality of life and BIomedical Cohort (NET-QUBIC) data warehouse and biobank

et al. 2019

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“…Methodological evaluation: INSERT Additional evidence also supports the prognostic significance of specific PROs such as PF and GHQ. A relationship between PF and survival time has been shown in a number of studies (60)(61)(62)(63)(64) and in a meta-analysis of 10,108 cancer patients (5). GHQ has also been associated with OS in different cancer types, highlighting its prognostic value (63,(65)(66)(67)(68).…”

Section: Insert Tablementioning

confidence: 90%

Prognostic value of patient-reported outcomes from international randomised clinical trials on cancer: a systematic review

Mierzynska

Piccinin

et al. 2019

The Lancet Oncology

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“…The importance of QOL and the implication on prognosis has been highlighted in head and neck cancer and cannot be understated. 30,31 This can be in part due to the impact of certain QOL factors such as pain (indicating return persistent or recurrent disease), dysphagia, poor oral intake, and sensory perception and survival. The results of this study may provide important areas of intervention, with potential implications on both quality of life and survival.…”

Section: E2219mentioning

confidence: 99%

Quality of Life Outcomes in Patients With Sinonasal Malignancy After Definitive Treatment

et al. 2020

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Objectives/Hypothesis: To describe multidimensional quality of life (QOL) outcomes in patients with sinonasal malignancies (SNM). To elucidate factors predicting worse QOL in this population.Study Design: Retrospective chart review at tertiary institution. Methods: A retrospective chart review on patients treated for SNM from 2006 to 2019 at a tertiary medical center was conducted. QOL outcomes were measured using the Hospital Anxiety and Depression Scale (HADS) and the Functional Assessment Cancer Therapy -Nasopharynx (FACT-NP) score. A stepwise multiple linear regression analysis was conducted to assess factors predicting worse QOL.Results: Eighty-one patients met inclusion criteria. Twelve (14.8%) patients had a subscale score >11 for anxiety (HADS-A) or depression (HADS-D) indicating significant anxiety or depression, at a median of 24 (8-68.5) months post treatment. The median FACT-NP total score was 136 (110-152). On multivariable analysis, advanced T classification, single status, and worse social support survey score were significant predictors of worse HADS score. Worse social support survey score was a significant predictor of worse total FACT-NP score.Conclusion: After adjusting for confounders, at a median of 24 months after completion of definitive therapy for SNM, advanced T classification and single relationship status were found to be significant predictors of anxiety and depression (based on HADS). A worse social support survey score was associated with worse anxiety, depression, and QOL (based on HADS and FACT-NP). Identifying these factors early may help to guide treatment and psychiatric referral to at-risk individuals after the treatment of SNM.

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The impact of treatment on quality of life of patients with head and neck cancer and its association with prognosis

Cited by 20 publications

References 25 publications

Advancing interdisciplinary research in head and neck cancer through a multicenter longitudinal prospective cohort study: the NETherlands QUality of life and BIomedical Cohort (NET-QUBIC) data warehouse and biobank

Advancing interdisciplinary research in head and neck cancer through a multicenter longitudinal prospective cohort study: the NETherlands QUality of life and BIomedical Cohort (NET-QUBIC) data warehouse and biobank

Prognostic value of patient-reported outcomes from international randomised clinical trials on cancer: a systematic review

Quality of Life Outcomes in Patients With Sinonasal Malignancy After Definitive Treatment

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