Modern education involves the active use of digital learning tools, which may have potential health risks for children and adolescents. Thus, the use of interactive panels (IP) in educational organizations, which everywhere replace traditional blackboards, causes a negative impact on the air parameters of classrooms: temperature rises, humidity decreases, and an imbalance in the content of positive and negative polarity aeroions appears. As you know, these indicators affect a person’s well-being, determine their performance, which determines the need to optimize classroom air. Comparative studies of the microclimate and aeroion composition of the air of classes equipped with IP have been carried out in the process of applying various methods of air optimization: additional wet cleaning, the use of an air humidifier and an air ionizer with a humidification function. Measurements were carried out in the dynamics of the educational organization’s school day: in the first, third and fifth lessons. The use of a humidifier and an ionizer helps to maintain the temperature, relative humidity and aeroionic composition of the air at a relatively stable level. In the absence of additional means of optimizing the air environment in classrooms with IP, the temperature, humidity and content of aeroions already in the middle of the school day go beyond the limits of hygienic standards. During additional wet cleaning, an almost similar pattern is observed, with the exception of the air humidity level, the decrease of which can be somewhat delayed. The results obtained indicate the expediency of optimizing classroom air when using an interactive panel: the use of a humidifier and/or an air ionizer contributed to maintaining the studied parameters practically within the normalized values throughout the school day.