Background and Purpose: Studying the effects of suction and injection on heat transportation in nanofluids for time-dependent boundary layer flow is a key topic in fluid dynamics. Aerodynamics and the sciences of space both make extensive use of these types of flow. In this research, nanodiamond and silver nanoparticles in water-type base-fluid nanofluids flow are analyzed under the effects of thermal radiation and non-Fourier theory.Methodology: A mathematical system having certain physical variations of the flow model is converted to a non-dimensional ordinary differential equation system via suitable similarity transformation variables. Then the flow model is numerically solved by RK4 and a shooting technique to describe the dynamics of the nanofluids under varied flow conditions. RK4 with the shooting approach gives a rapid result with high convergence accuracy. The relevant characteristics of physical quantities evaluated by an inclusive numerical scheme are observed for flow pattern, temperature distribution, and nanofluids concentration variations in the presence of suction and injection fluxes.Finding: According to the findings, both ND-H2O and Ag-H2O have outstanding thermal performance characteristics. The Ag-based nanofluid, however, has a better heat transfer capability. To validate the analysis, a graphical and tabular comparison is presented under specified assumptions. The key finding is that, with the injection effect, the heat flow rate is larger than with the suction effect. The unsteadiness parameter causes a drop in the velocity profile, whereas energy distribution rises with this parameter.