The Impact of Variant Philadelphia Chromosome Translocations on the Clinical Course of Chronic Myeloid Leukemia

Eyupoglu, Damla; Bozkurt, Süreyya; Haznedaroğlu, İbrahim C.; Büyükaşık, Yahya; Güven, Deniz Can

doi:10.4274/tjh.2015.0237

Cited by 13 publications

(10 citation statements)

References 21 publications

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“…This chromosome was translocated recurrently to form the variant Philadelphia chromosome according to previous studies [ 7 ]. The impact of the variant Philadelphia chromosome on disease progression is controversial [ 13 ]. Some authors consider this chromosome as an indicator of poor prognosis, particularly before imatinib was used for treatment [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Additional cytogenetic aberrations in chronic myeloid leukemia: a single-center experience in the Middle East

et al. 2018

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BackgroundAdditional cytogenetic aberrations are associated with disease progression in chronic myeloid leukemia (CML). This study was conducted to determine the type and frequency of these aberrations and their relationship with hematologic and molecular findings in the Middle East.MethodsIn this retrospective study, 134 well-established cases of CML were selected from 2010 to 2016. Their hematologic phase and type of fusion gene were determined. Finally, their karyotypes were analyzed and reported according to ISCN 2013.ResultsPatients had a mean age of 44 years. Twenty-two patients (16.4%) showed additional cytogenetic aberrations. Nine patients (6.7%) harbored a variant Philadelphia chromosome, and most were in the chronic phase. Seventeen patients (12.7%) had major and minor route abnormalities. There was a significant relationship between additional cytogenetic aberrations and major molecular response (P=0.032). Patient survival in the group with additional cytogenetic aberrations was significantly lower (49.7±11.1 mo) than that in the group without additional cytogenetic aberrations (77.3±3.1 mo) (P=0.031).ConclusionThis study revealed the same frequency of additional cytogenetic aberrations in CML as found in previous studies. Additional chromosomal aberrations led to shorter survival and lower rates of achievement of a major molecular response.

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Section: Discussionmentioning

confidence: 99%

Additional cytogenetic aberrations in chronic myeloid leukemia: a single-center experience in the Middle East

et al. 2018

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“…In conclusion, the laboratory diagnostic characterization studies has allowed us: necessary for variant Ph positve leukemia [29][30] .…”

Section: Resultsmentioning

confidence: 99%

Laboratory characteristics of patients with variant Phiadelphia chromosome positive leukemia

Song

Guo

Wang

et al. 2020

Preprint

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Background Variant Philadelphia chromosomes are characterized by the involvement of another chromosome in addition to chromosome 9 or 22. To detect the difference between variant Philadelphia chromosomes positive leukemia and classic Philadelphia chromosomes positive leukemia. And to help diagnose and treat variant Philadelphia chromosomes positive leukemia. Methods In this study, Peripheral blood and bone morrow cell morphology test was used to analysis bone morphology of variant Ph positive patients. Karyotype analysis was used to find out variant Ph chromosomes. Flow cytometry analysis was used for immunology analysis. BCR/ABL was detected by PCR to monitor change of molecular genetics in variant Ph positive patients. Results From 48 patients with Ph positive leukemia, we found out 3 variant Ph positive leukemia. Compared with the classic Ph positive leukemia patients, the hemogram in the variant Ph positive leukemia patients was more variant for presenting hypomyelodysplasia or hyperactive. Compared with classic chronic myeloid leukemia which neutrophilic myelocyte, metamyelocyte and stab granulocyte is increasing in, both the morphological testing of bone marrow cells smear and flow cytometry analysis were indicated that proportion of myeloblast and promyelocyte increased in variant Philadelphia chromosomes leukemia. What’s more, the variant Ph with breakpoint 4q31 was the first report in leukemia patient. Same as the classic Ph positive leukemia patient, formal and effective treatment could prolong the survival of patients with variant Ph positive leukemia. Conclusions Compared with classic Ph positive leukemia, the hemogram was more variant in variant Ph. The myeloid morphology in the patients with variant Ph was more immature than that of in the patients with classic Ph. Reporting new cases of complex variant translocations, which can refer to new breakpoints that can eventually be recurrent and important for the understanding of this leukemia. Formal and effective treatment are necessary for variant Ph positve leukemia.

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“…Most common symptoms are signs of the patients with CML are fatigue, malaise, weight loss, anemia and splenomegaly [5]. Reciprocal Philadelphia chromosome translocations are manifested by 90% cases of CML [6]. Current treatment of CML includes tyrosine kinase inhibitors (TKIs) such as Imatinib [5].…”

Section: Introductionmentioning

confidence: 99%

Chronic myeloid leukemia revealed by bilateral proliferative retinopathy: A case report and literature review

Quiddi¹,

Boumaazi²,

Sayagh³

2021

GSC Adv. Res. Rev.

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Bilateral proliferative retinopathy is a rare complication of chronic myeloid leukemia (CML) as a few case reports have been published to date. In this case report, a 32-year old diabetic female presented with history of bilaterally decreased vision. Ophthalmologic examination showed bilateral proliferative retinopathy (i.e., retinal detachment, vitreous hemorrhage, pre-retinal fibrosis and the presence of bilateral peripheral capillary dropout with multiple retinal sea fan neovascularization) for which panretinal laser photocoagulation and vitrectomy were planned. During the preoperative workup, complete blood count revealed hyperleukocytosis. Later on, the karyotype analysis identified Philadelphia chromosome, confirming the diagnosis of CML. Hence, it was an interesting case where bilateral proliferative retinopathy directed to the diagnosis of CML. Therefore, proliferative retinopathy may be the first presentation of CML.

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The Impact of Variant Philadelphia Chromosome Translocations on the Clinical Course of Chronic Myeloid Leukemia

Cited by 13 publications

References 21 publications

Additional cytogenetic aberrations in chronic myeloid leukemia: a single-center experience in the Middle East

Additional cytogenetic aberrations in chronic myeloid leukemia: a single-center experience in the Middle East

Laboratory characteristics of patients with variant Phiadelphia chromosome positive leukemia

Chronic myeloid leukemia revealed by bilateral proliferative retinopathy: A case report and literature review

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