The impact of vitamin D supplementation as an adjuvant therapy on clinical outcomes in patients with severe atopic dermatitis: A randomized controlled trial

Mansour, Noha O.; Mohamed, Amal Ahmed; Hussein, Maha S.; Eldemiry, Eman Mohamed Bahgat; Daifalla, Aliaa; Hassanin, Soha Osama; Nassar, Nourelhuda Ahmed; Ghaith, Doaa; Ahmed, Eman M.

doi:10.1002/prp2.679

Cited by 36 publications

(31 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We assessed the heterogeneity among the studies using I 2 (considered heterogeneity existed if I 2 > 25%), then Random Effect Model was adopted. For publication bias, we used funnel plot and it can be seen that the four Camargo, 2014 14 Galli, 2015 19 Lara-Corrales, 2018 13 Sanchez-Armendariz, 2018 15 Earlia, 2020 16 Mansour, 2020 20 studies are distributed symmetrically, that is, the distribution of research is balanced on the left and right of the centre line boundary. This means that there is no potential for publication bias regarding the conclusions.…”

Section: Discussionmentioning

confidence: 99%

“…Qualitative synthesis then resulted two studies that could not be included in the meta-analysis due the fact that no standard deviation was reported 19 and. 20 A further two studies were also excluded due to the study design which was single-arm cohort 21 and 22 so that the final results were four articles which were then analysed in this study.…”

Section: Recruitmentmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of vitamin D supplementation on the severity of atopic dermatitis in children: A systematic review and meta-analysis

et al. 2022

View full text Add to dashboard Cite

Background: Atopic Dermatitis (AD) is a common dermatosis in children, that includes skin architecture defects, immune dysregulation, and changes of skin flora. Several new drugs have been found to reduce the severity of AD. Vitamin D is one of the new therapies that is still controversial. The purpose of this research is to conclude the efficacy of vitamin D on atopic dermatitis severity in children aged 0-18 years old. Methods: A systematic search was conducted on the PubMed, Cochrane, ProQuest, Google Scholar, Clinical Trial website, and university repositories including studies published from January 2010 through October 2020. We compared populations, intervention, study design, and outcomes. Statistical analysis was done with Review Manager 5.4.1. Results: Eight articles met eligibility and inclusion criteria, four articles provided complete data and were analysed. Not all studies demonstrated the efficacy of vitamin D but a meta-analysis of four studies of vitamin D supplementation vs placebo found a mean difference of -0.93 (95%CI -1.76, to -0.11, p<0.001) of patient outcome, but statistically, there was no difference in cure rate (risk ratio 1.46 (95%CI 0.72, to 2.97, p=0.008) in vitamin D supplementation groups compared to placebo groups. Conclusions: Vitamin D supplementation in paediatric atopic dermatitis patients could offer improvement of disease severity but the recommended dose and duration of administration cannot be concluded yet.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Recruitmentmentioning

confidence: 99%

Efficacy of vitamin D supplementation on the severity of atopic dermatitis in children: A systematic review and meta-analysis

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Vitamin. D3 also has an important role in immunity, as it improves innate and adaptive immune responses by altering local calcium balance and by binding to nuclear vitamin receptors, which regulate gene transcription [8]. Vitamin.…”

Section: Clinico-biochemical Relation Of Vitamin D3 With the Severity...mentioning

confidence: 99%

Clinico-biochemical relation of Vitamin D3 with the severity of atopic dermatitis and response to supplementation of Vitamin D3: A randomized controlled trial

Modi¹,

Dash²

2022

Indian J Child Health

View full text Add to dashboard Cite

Background: Atopic dermatitis (AD), also known as eczema, is one of the most common skin disorders among children and adults, with a steep rise in diagnoses among children. Many studies have investigated the relationship between Vitamin D3 (Vit D3) and AD. Methods: A randomized controlled trial was conducted among 60 children at SCB Medical College, Cuttack from August 2014 to November 2016. Children were randomly assigned to an intervention group that received 60,000 IU of Vit. D3 every week for 6 weeks in addition to regular treatment for AD and a control group that received same treatment of AD except for Vit. D3. Both the groups were followed up at 4 weeks and 8 weeks. Results: In 60 cases of moderate to severe AD, 70% of the patients were male. About 81.7% of patients were from urban areas and 56.7% belonged to a middle socioeconomic class. In 76.6% of cases, family history of atopy was present. At baseline, mean SCORAD was 47.8±7.5 in the intervention group, and 49.2±10.3 in the control group. At baseline, serum Vitamin. D3 level (ng/ml) was 17.6±1.8 in intervention and 17.3±3.5 in control group. After Vitamin. D3 supplementation, the SCORAD improved to 12.8±5.1 (75% reduction) at 4 weeks, and 3.6±2.1 (92% reduction) at 8 weeks in the intervention group. In the control group, the mean SCORAD was 18.8±9.1 (61% reduction) at 4 weeks, and 7.3±4 (85% reduction) at 8 weeks. Discussion: The improvement of serum 25-hydroxy Vit. D3 was 134% and 366% in the intervention group compared to 78% and 121% in the observation group after 4 weeks and 8 weeks respectively. The p-values at both the time points were significant (<0.05) for the intervention group as compared to the control group. Conclusion: Short-term therapeutic supplementation of Vitamin. D3 in children with moderate to severe AD improves the clinical score. There is an inverse relationship between serum Vitamin. D3 level and severity of AD.

show abstract

unclassified

“…Apžvelgę naujausių klinikinių tyrimų rezultatus, galime pastebėti tendenciją, kad peroralinė D vitamino terapija teigiamai veikia pacientų, sergančių atopine egzema, odos būklę [18,[20][21][22][23][24][25]. Daugumos tyrimų pabaigoje SCORAD arba EASI indeksas statistiškai reikšmingai labiau sumažėjo grupėje, gavusioje D vitamino papildų, lyginant su placebo grupe [18,20,21]. Tik vieni tyrėjai nenustatė statistiškai reikšmingo ryšio tarp tiriamųjų grupių Klinikinių studijų rezultatai parodė, kad geriamieji D vitamino preparatai galimai sumažina S.aureus kolonizaciją odoje ir taip palengvina atopinio dermatito eigą [20].…”

unclassified

Geriamųjų D Vitamino Preparatų Terapinis Poveikis Pacientams, Sergantiems Atopiniu Dermatitu

Petruškevičiūtė¹,

Kisielienė²

2022

Health Sciences

View full text Add to dashboard Cite

Tikslas – išanalizuoti ir apibendrinti klinikines studijas, tiriančias geriamųjų D vitamino papildų terapinį poveikį atopine egzema sergantiems pacientams. Tyrimo metodas – sisteminė literatūros apžvalga. Mokslinės literatūros paieška atlikta naudojantis PubMed ir UpToDate medicinos duomenų bazėmis. Buvo peržiūrėtos 2015–2021 metais anglų kalba išspausdintos publikacijos, bei šių publikacijų šaltiniai. Rezultatai. Mokslinėje literatūroje daugėja įrodymų, kad yra ryšys tarp D vitamino stokos ir egzemos išsivystymo. Lyginant sveikus tiriamuosius, bei pacientus, sergančius atopine egzema, pastebėta, kad atopiniu dermatitu sergančių pacientų 25(OH)D koncentracija kraujo serume yra statistiškai reikšmingai mažesnė. Mažėjant D vitamino koncentracijai kraujo serume, didėja AD sunkumas pagal SCORAD indeksą. Apžvelgę naujausių klinikinių tyrimų rezultatus, galime pastebėti tendenciją, kad peroralinė D vitamino terapija teigiamai veikia pacientų, sergančių atopine egzema, odos būklę. Išvados. Nors klinikinių tyrimų rezultatai vis dar yra nevienareikšmiai, daugėja duomenų, kad peroralinė D vitamino terapija mažina atopinio dermatito simptomus bei apsaugo nuo S.aureus kolonizacijos odoje. Kadangi klinikinių studijų skirtinga metodika, norint sukaupti pakankamai mokslu pagrįstų įrodymų šia tema, reikalingi struktūrizuoti, daugiacentriniai, didelės apimties klinikiniai tyrimai.

show abstract

The impact of vitamin D supplementation as an adjuvant therapy on clinical outcomes in patients with severe atopic dermatitis: A randomized controlled trial

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 36 publications

References 30 publications

Efficacy of vitamin D supplementation on the severity of atopic dermatitis in children: A systematic review and meta-analysis

Efficacy of vitamin D supplementation on the severity of atopic dermatitis in children: A systematic review and meta-analysis

Clinico-biochemical relation of Vitamin D3 with the severity of atopic dermatitis and response to supplementation of Vitamin D3: A randomized controlled trial

Geriamųjų D Vitamino Preparatų Terapinis Poveikis Pacientams, Sergantiems Atopiniu Dermatitu

Contact Info

Product

Resources

About