In a wastewater treatment plant (WWTP), several sludge streams exist and the composition of their liquid phase varies with time and place. For evaluating the potential for formation of precipitates and equilibria for weak acids/bases the ionic strength and chemical composition needs to be known. This information is often not available in literature, and even neglected in chemical model-based research. Based on a literature review, we proposed 3 ranges of concentration (low, typical and high) for the major constituents of the liquid phase of the different streams in a WWTP. The study also discusses the reasons for the concentration evolution, and the exceptional cases, to allow readers to consider the right range depending on their situation. The ionic strength of the different streams and the contribution of its constituents was calculated based on the ionic composition. The major contributors to the ionic strength for the wastewater-based streams (influent, effluent and mixed sludge) were Na+, Cl−, Mg2+ and Ca2+ representing 50–70% of the ionic strength. For digestate, and accounted for 65–75% of the ionic strength. Even though the ionic strength is recognised to impact several important wastewater treatment processes, its utilization in literature is not always adequate, which is discussed in this study.