The impact of zinc on the molecular signaling pathways in the diabetes disease

Asghari, Keyvan; Shargh, Zahra; Fatehfar, Sina; Chodari, Leila; Sameei, Parsa

doi:10.1016/j.jtemb.2022.126985

Cited by 7 publications

(3 citation statements)

References 88 publications

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“…It is known that the development of cardiac dysfunction is closely associated with increased mitochondrial reactive oxygen species (ROS) production, which could be caused by different pathological conditions (such as hyperglycaemia or hyperlipidaemia). In particular, Zn 2+ -associated signalling pathways are involved in the development of diabetic cardiomyopathy and other heart diseases [6,7]. In that regard, the close coordination of [Ca 2+ ] i and [Zn 2+ ] i homeostasis in mitochondrion balances the redox status and oxidative stress status of cardiomyocytes and provides a cardioprotective effect [8].…”

Section: Introductionmentioning

confidence: 99%

Interplay between Zn2+ Homeostasis and Mitochondrial Functions in Cardiovascular Diseases and Heart Ageing

Dabravolski

Sadykhov

Kartuesov

et al. 2022

IJMS

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Zinc plays an important role in cardiomyocytes, where in exists in bound and histochemically reactive labile Zn2+ forms. Although Zn2+ concentration is under tight control through several Zn2+-transporters, its concentration and intracellular distribution may vary during normal cardiac function and pathological conditions, when the protein levels and efficacy of Zn2+ transporters can lead to zinc re-distribution among organelles in cardiomyocytes. Such dysregulation of cellular Zn2+ homeostasis leads to mitochondrial and ER stresses, and interrupts normal ER/mitochondria cross-talk and mitophagy, which subsequently, result in increased ROS production and dysregulated metabolic function. Besides cardiac structural and functional defects, insufficient Zn2+ supply was associated with heart development abnormalities, induction and progression of cardiovascular diseases, resulting in accelerated cardiac ageing. In the present review, we summarize the recently identified connections between cellular and mitochondrial Zn2+ homeostasis, ER stress and mitophagy in heart development, excitation–contraction coupling, heart failure and ischemia/reperfusion injury. Additionally, we discuss the role of Zn2+ in accelerated heart ageing and ageing-associated rise of mitochondrial ROS and cardiomyocyte dysfunction.

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Section: Introductionmentioning

confidence: 99%

Interplay between Zn2+ Homeostasis and Mitochondrial Functions in Cardiovascular Diseases and Heart Ageing

Dabravolski

Sadykhov

Kartuesov

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…It is known that Zn 2+ -associated signalling pathways are involved in the development of diabetic cardiomyopathy and other heart diseases. Mitochondria coordinate [Ca 2+ ] i and [Zn 2+ ] i homeostasis, which affect cellular ROS production, mitochondria ultrastructure and efficiency [106,107]. The role of Zn 2+ homeostasis in DM and obesity-induced cardiac remodelling, inflammation, dysfunction and other cardiovascular diseases and complications was covered in several recent reviews [108][109][110].…”

Section: Zinc Supplementation In Dm Treatment and Cardioprotectionmentioning

confidence: 99%

The Role of Mitochondrial Abnormalities in Diabetic Cardiomyopathy

Dabravolski

Sadykhov

Kartuesov

et al. 2022

IJMS

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Diabetic cardiomyopathy (DCM) is defined as the presence in diabetic patients of abnormal cardiac structure and performance (such as left ventricular hypertrophy, fibrosis, and arrhythmia) in the absence of other cardiac risk factors (such as hypertension or coronary artery disease). Although the pathogenesis of DCM remains unclear currently, mitochondrial structural and functional dysfunctions are recognised as a central player in the DCM development. In this review, we focus on the role of mitochondrial dynamics, biogenesis and mitophagy, Ca2+ metabolism and bioenergetics in the DCM development and progression. Based on the crucial role of mitochondria in DCM, application of mitochondria-targeting therapies could be effective strategies to slow down the progression of the disease.

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“…13,14 Zinc and zinc transporter proteins are involved in the pathophysiology of many human diseases, from cancer to neurological and neuropsychiatric disorders, aging, diabetes and infections. 15,16 Food fortification is the best aid to prevent zinc deficiency and can significantly improve zinc absorption and bioavailability. 17 Some studies have shown that consumption of zinc-fortified foods can increase mineral intake.…”

Section: Introductionmentioning

confidence: 99%

Dietary zinc supplements: beneficial health effects and application in food, medicine and animals

Shi,

Hao,

et al. 2024

J Sci Food Agric

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Zinc, a crucial trace element is vital for the growth and development of humans. It is frequently described as ‘the flower of life’ and ‘the source of intelligence’. Zinc supplements play a pivotal role in addressing zinc deficiency by serving as a vital source of this essential micronutrients, effectively replenishing depleted zinc levels in the body. In this paper, we first described the biological behavior of zinc in the human body and briefly described the physiological phenomena associated with zinc levels. The benefits and drawbacks of various zinc supplement forms are then discussed, with emphasis on the most recent zinc supplement formulations. Finally, the application of zinc supplements in food, medicine, and animal husbandry is further summarized. © 2024 Society of Chemical Industry.

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The impact of zinc on the molecular signaling pathways in the diabetes disease

Cited by 7 publications

References 88 publications

Interplay between Zn2+ Homeostasis and Mitochondrial Functions in Cardiovascular Diseases and Heart Ageing

Interplay between Zn2+ Homeostasis and Mitochondrial Functions in Cardiovascular Diseases and Heart Ageing

The Role of Mitochondrial Abnormalities in Diabetic Cardiomyopathy

Dietary zinc supplements: beneficial health effects and application in food, medicine and animals

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