The impact of β‐blockers on the central and delta systolic pressures in a real‐world population with treated hypertension: A cross‐sectional study

Bénard, Brigitte; Durand, Madéleine; Berthoumieux, Sylvie; Gauthier, Martine; L'Archevêque, Hélène; Lamarre-Cliché, Maxime; Laskine, Mikhael

doi:10.1002/hsr2.948

Cited by 1 publication

(5 citation statements)

References 24 publications

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“…While there are many chemical drugs available to treat cardiovascular disease, some of them have side effects or do not respond well enough. The therapeutic limits of approved therapy are characterized by a whole range of negative features, and often have allergic effects, so they must be excluded [19][20][21][22][23][24][25][26][27][28][29][30][31][32]. Conventional therapy of CVDs requires an individual approach to patients, while on the other hand, the application of natural products does not have that kind of limitation.…”

Section: Discussionmentioning

confidence: 99%

“…Each of them has different mechanisms of action, so some regulate the elimination of water and sodium [29,31]. Others decrease renin release in renal juxtaglomerular cells by blockade beta receptors [30]. Calcium channel blockers relax blood vessels by decreasing the influx of calcium ions into the cells [30].…”

Section: Discussionmentioning

confidence: 99%

“…Others decrease renin release in renal juxtaglomerular cells by blockade beta receptors [30]. Calcium channel blockers relax blood vessels by decreasing the influx of calcium ions into the cells [30]. There is an important link between complex oxidation reactions and the development of atrial hypertension.…”

Section: Discussionmentioning

confidence: 99%

“…Beta-blockers, also known as beta-adrenergic blockers, block the action of the hormone epinephrine (adrenaline) on β1 and β2 receptors leading to decreased myocardial contractility and frequency as well as decreasing renin release in renal juxtaglomerular cells, thus lowering blood pressure. Possible side effects of beta blockers include bradycardia or atrioventricular blocks, heart block, insomnia, sleep disturbances, constipation, and sexual and/or erectile dysfunction [30].…”

Section: Treatment Of Arterial Hypertension Using Approved Drugsmentioning

confidence: 99%

“…Numerous studies in the past decades have been performed to develop better therapeutic strategies, but current medications for CVDs mainly target disease symptoms like therapeutics for CAD disease [19][20][21][22], acute myocardial infarction [23], atrial fibrillation [24][25][26], chronic heart failure [27,28], and arterial hypertension [29][30][31][32], respectively. Physicians should be careful in choosing the right kind of treatment depending on the type of disease that a patient has.…”

Section: Introductionmentioning

confidence: 99%

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Natural Substances vs. Approved Drugs in the Treatment of Main Cardiovascular Disorders—Is There a Breakthrough?

Grujić-Milanović,

Rajković,

Milanović

et al. 2023

Antioxidants

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Cardiovascular diseases (CVDs) are a group of diseases with a very high rate of morbidity and mortality. The clinical presentation of CVDs can vary from asymptomatic to classic symptoms such as chest pain in patients with myocardial infarction. Current therapeutics for CVDs mainly target disease symptoms. The most common CVDs are coronary artery disease, acute myocardial infarction, atrial fibrillation, chronic heart failure, arterial hypertension, and valvular heart disease. In their treatment, conventional therapies and pharmacological therapies are used. However, the use of herbal medicines in the therapy of these diseases has also been reported in the literature, resulting in a need for critical evaluation of advances related to their use. Therefore, we carried out a narrative review of pharmacological and herbal therapeutic effects reported for these diseases. Data for this comprehensive review were obtained from electronic databases such as MedLine, PubMed, Web of Science, Scopus, and Google Scholar. Conventional therapy requires an individual approach to the patients, as when patients do not respond well, this often causes allergic effects or various other unwanted effects. Nowadays, medicinal plants as therapeutics are frequently used in different parts of the world. Preclinical/clinical pharmacology studies have confirmed that some bioactive compounds may have beneficial therapeutic effects in some common CVDs. The natural products analyzed in this review are promising phytochemicals for adjuvant and complementary drug candidates in CVDs pharmacotherapy, and some of them have already been approved by the FDA. There are insufficient clinical studies to compare the effectiveness of natural products compared to approved therapeutics for the treatment of CVDs. Further long-term studies are needed to accelerate the potential of using natural products for these diseases. Despite this undoubted beneficence on CVDs, there are no strong breakthroughs supporting the implementation of natural products in clinical practice. Nevertheless, they are promising agents in the supplementation and co-therapy of CVDs.

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