“…Air temperature, especially cold temperature, has a short-term effect on blood pressure (Xu et al, 2019) because exposure to cold temperatures can increase activation and vasoconstriction of the sympathetic nervous system, and reduce endothelial function, which can lead to increased blood pressure (Park et al, 2020). The results of this study are in line with the findings showing that the percentage of patients with large-artery atherosclerosis (LAA) in the low-temperature group was significantly greater than that in the non-low-temperature group (p<0.05) because low temperatures can cause an increase in platelets and red blood cells, as well as increase blood viscosity, adhesion and platelet activation, all of which can lead to thrombosis (Chen et al, ), 2021Chen, Shang, et al, 2019;Halil Gibran & Heriyani, 2020;Hartwig et al, 2021;Jayarajah & Seneviratne, 2019;Karim et al, 2021;Polcaro-Pichet et al, 2019;Tochihara et al, 2021;Toffoli et al, 2023;Umishio et al, 2019;Wu et al, 2021a).…”