The present experimental study aims to contribute to the knowledge of the physical-mechanical properties of limestone blocks quarried in the Republic of Moldova. Apparent density, water absorption and compressive strength are examined based on laboratory work. The masonry material - limestone blocks are characterized both in comparison with other types of masonry materials and by comparing the compressive strength with other types of limestones. The analysed limestone samples were taken from 3 limestone quarries located in different areas on the territory of the Republic of Moldova. The results showed that limestone blocks from Moldova have better properties than AAC and some bricks. The materials used in the experimental work were selected to be representative of the mechanical characteristics present in old and existing buildings in Chisinau. This research is significant for the variation of the physical-mechanical properties of Moldovan limestone blocks compared to the same properties of other types of masonry blocks.