This the article analyzes in-depth the mechanism of how digital service trade impacts the high-quality development of the manufacturing industry. Also, by selecting 30 provinces in China from 2003 to 2020 as samples, the paper empirically analyzes the impact and path of digital service trade on the high-quality development of the manufacturing industry by using the chain multiple intermediary effects model and spatial Durbin model. The empirical results show that: (1) digital service trade has a positive impact on the high-quality development of China’s manufacturing industry; (2) digital service trade can positively impact the high-quality development of the manufacturing industry by promoting human capital, green technology innovation, and chain intermediary effects between the two; (3) compared with the eastern region and the central-western region, digital service trade has a greater promotion effect on the high-quality development of the manufacturing industry in the central-western region.