Over the last decade, learning and working in medicine has been increasingly influenced by digital tools. Today’s medical students are growing up in a digital age where digital tools and devices are a regular part of professional life. The development of digital competence is crucial for healthcare education, as healthcare professionals will be the ones helping orientate patients in digital healthcare systems and tools. This study aims to explore the opinions and experiences of medical college students regarding the factors influencing digital competence. Four focus group discussions were organised, with 26 medical college students in total in various study programmes in December 2021. The interviews were conducted in Latvian and transcribed by the lead researcher. Thematic analysis of the focus group discussions identified four main themes to be associated with the factors influencing digital competence: personal factors (self-confidence in using Information and Communication Technologies (ICTs), attitudes towards ICTs, prior training on ICTs, motivation), learning design (online, blended learning), lecturers’ digital competence and external aspects (family support, Covid-19 pandemic). This study presented results that could also be helpful for other universities to promote targeted development and improvement of digital competence of their students.