The Impacts of Gastroileostomy Rat Model on Glucagon-like Peptide-1: a Promising Model to Control Type 2 Diabetes Mellitus

Keleidari, Behrouz; Mofrad, Rastin Mohammadi; Shahabi, Shahab; Sanei, Mohammad Hossein; Kolahdouzan, Mohsen; Sheikhbahaei, Erfan

doi:10.1007/s11695-018-3312-y

Cited by 6 publications

(4 citation statements)

References 33 publications

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“…Reduced metabolic rate results from adaptive thermogenesis following post-bariatric weight loss and alterations in fat mass and lean body mass in the first six months ( 17 , 36 ). As mentioned earlier, WR might also be a result of changes and imbalances in the gut and adipocyte hormones, which comprise rising ghrelin, neuropeptide Y (NPY), insulin sensitivity, and dropped peptide YY (PYY), cholecystokinin (CCK), glucagon-like peptide 1 (GLP-1), serotonin, and leptin and eventually hypoglycemic, and even insulin resistance ( 17 , 36 , 49 , 50 ). Finally, abnormal estrogen levels among women have been implicated in WR ( 49 ).…”

Section: Resultsmentioning

confidence: 99%

What About My Weight? Insufficient Weight Loss or Weight Regain After Bariatric Metabolic Surgery

Zefreh,

Amani-Beni,

Sheikhbahaei

et al. 2023

Int J Endocrinol Metab

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Context: This review study aimed to investigate the definition, etiology, risk factors (RFs), management strategy, and prevention of insufficient weight loss (IWL) and weight regain (WR) following bariatric metabolic surgery (BMS). Evidence Acquisition: Electronic databases were searched to retrieve relevant articles. The inclusion criteria were English articles with adult participants assessing the definition, prevalence, etiology, RFs, management strategy, and prevention of IWL/WR. Results: Definition: The preferred definition for post-BMS IWL/WR are the terms "Lack of maintenance of total weight loss (TWL)>20%" and "weight change in percentage compared to nadir weight or weight loss". Prevalence: The exact prevalence of IWL/WR is still being determined due to the type of BMS and various definitions. Etiology: Several mechanisms, including hormonal/metabolic, dietary non-adherence, physical inactivity, mental health, and anatomic surgical failure, are possible etiologies of post-BMS IWL/WR. RFs: Preoperative body mass index (BMI), male gender, psychiatric conditions, comorbidities, age, poor diet, eating disorders, poor follow-ups, insufficient physical activity, micronutrients, and genetic-epigenetic factors are the most important RFs. Management Strategy: The basis of treatment is lifestyle interventions, including dietary, physical activity, psychological, and behavioral therapy. Pharmacotherapy can be added. In the last treatment line, different techniques of endoscopic surgery and revisional surgery can be used. Prevention: Behavioral and psychotherapeutic interventions, dietary therapy, and physical activity therapy are the essential components of prevention. Conclusions: Many definitions exist for WR, less so for IWL. Etiologies and RFs are complex and multifactorial; therefore, the management and prevention strategy is multidisciplinary. Some knowledge gaps, especially for IWL, exist, and these gaps must be filled to strengthen the evidence used to guide patient counseling, selection, and improved outcomes.

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Section: Resultsmentioning

confidence: 99%

What About My Weight? Insufficient Weight Loss or Weight Regain After Bariatric Metabolic Surgery

Zefreh,

Amani-Beni,

Sheikhbahaei

et al. 2023

Int J Endocrinol Metab

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“…Moreover, long-term administration of amylin or an amylin agonist induces weight loss (Mietlicki-Baase et al, 2015;Lutz, 2012). With regard to GLP-1, this hormone stimulates the synthesis and secretion of insulin (Lee & Jun, 2014) and elevated levels of GLP-1 are associated with weight loss (Keleidari et al, 2018;Koliaki & Doupis, 2011). Plasma levels of GLP-1 also increase following food consumption, and the release of GLP-1 prevents pancreatic β-cell death (Keleidari et al, 2018).…”

Section: Insulin Biomarkersmentioning

confidence: 99%

“…With regard to GLP-1, this hormone stimulates the synthesis and secretion of insulin (Lee & Jun, 2014) and elevated levels of GLP-1 are associated with weight loss (Keleidari et al, 2018;Koliaki & Doupis, 2011). Plasma levels of GLP-1 also increase following food consumption, and the release of GLP-1 prevents pancreatic β-cell death (Keleidari et al, 2018). Thus, it is possible that STZ-treated rats displayed higher levels of GLP-1 in response to lower levels of plasma insulin.…”

Section: Insulin Biomarkersmentioning

confidence: 99%

“…This effect of insulin might explain the increases in food intake, weight change, GLP-1, and amylin levels that were observed in insulin-treated rats. Indeed, GLP-1 levels have been shown to increase in procedures that enhance food consumption in rodents (Keleidari et al, 2018). Also, administration of amylin has been shown to produce a hypoglycemic state in healthy mice, suggesting that hypoglycemia may produce elevated amylin levels in rodents (Guerreiro et al, 2013).…”

Section: Other Considerationsmentioning

confidence: 99%

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Insulin modulates the strong reinforcing effects of nicotine and changes in insulin biomarkers in a rodent model of diabetes

Cruz

Flores

Uribe

et al. 2019

Neuropsychopharmacol.

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Ibarra, Francisco Flores, and Israel Garcia. Many thanks for their countless help, encouragement, and laughs throughout this time in graduate school. I could not have asked for a better group of people to work with. Lovingly, I would like to thank my parents, Gerardo Cruz and Carmen Rios, and my siblings, Narlin Cruz and Jerry Cruz, for their endless love and support for my life goals. Many thanks to my best friends, Jorge Abraham Rodriguez and Adrian Macias for their constant encouragement. Lastly and lovingly, I would like to thank Claudia Jane Woloshchuk for her immense patience, support, commitment, and for always be there for me throughout this time. All of their continuous reinforcement is the spark for my enthusiasm.

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Long-Term Diabetes Improvement After Duodenal Exclusion in Zucker Diabetic Fatty Rats Is Associated with Prevention of Strain-Specific Pancreatic Remodeling and Increased Beta Cell Proliferation

et al. 2022

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Background Response to metabolic surgery is heterogeneous and the metabolic states that underpin weight loss and metabolic improvement are still unclear. In this study, we investigate parameters of post-bariatric fasting glucoregulation and leverage artificial intelligence-assisted whole-slide image analyses to characterize associated immunohistologic features of the pancreas. Materials and Methods We performed either loop duodeno-jejunostomy (DJOS) with exclusion of 1/3 of total intestinal length, loop duodeno-ileostomy with exclusion of 2/3 of total intestinal length (DiOS), or a sham operation on 8-week-old male obese ZDF rats. Six months post-operative, we measured blood metabolites and hormones. Subsequently, pancreatic and intestinal tissue was removed, formalin fixed, and paraffin embedded. Immunohistologic (IHC) analyses included proliferating cell nuclear antigen (PCNA) to visualize the proliferation fraction and pancreatic and duodenal homeobox 1 (PDX 1) as a measure of pancreatic cell differentiation. For IHC quantification, all slides were digitalized and analyzed using QuPath. All analyzed slides were reviewed by two independent pathologists for correctness. Results DJOS and DiOS were associated with preserved fasting insulin production compared to sham. Histopathologic evaluation showed significantly higher numbers of beta cells and specifically of clustered cell organization in DJOS and DiOS compared to sham. Cell proliferation (PCNA) was significantly elevated in DJOS and DiOS compared to sham. Conclusion In this interventional model of bariatric surgery in severe genetic diabetes, we demonstrate post-operative histologic and immunohistologic features of the pancreas associated with improved fasting glucose homeostasis. Graphical abstract

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The Impacts of Gastroileostomy Rat Model on Glucagon-like Peptide-1: a Promising Model to Control Type 2 Diabetes Mellitus

Abstract: In this study, we showed the effectiveness of gastroileostomy treatment to decrease body weight and plasma glucose with increased GLP-1 in rats. This small rat model suggests the potential of this surgery to treat type 2 diabetes mellitus.

Cited by 6 publications

References 33 publications

What About My Weight? Insufficient Weight Loss or Weight Regain After Bariatric Metabolic Surgery

What About My Weight? Insufficient Weight Loss or Weight Regain After Bariatric Metabolic Surgery

Insulin modulates the strong reinforcing effects of nicotine and changes in insulin biomarkers in a rodent model of diabetes

Long-Term Diabetes Improvement After Duodenal Exclusion in Zucker Diabetic Fatty Rats Is Associated with Prevention of Strain-Specific Pancreatic Remodeling and Increased Beta Cell Proliferation

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