The impacts of health insurance and resource on the burden of Alzheimer's disease and related dementias in the world population

Wang, Jintao; Xu, Gang; Ren, Rong; Wang, Ying; Tang, Ran; Huang, Qiang; Li, Jianping; Al‐Nusaif, Murad; Wang, Gang

doi:10.1002/alz.12730

Cited by 9 publications

(4 citation statements)

References 43 publications

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“…It is estimated that the number of people with dementia will reach 152.8 million in 2050, an increase from 57.4 million in 2019 [[3]]. The ranking of dementia as a cause of death has continued to rise from ninth in 1990 to seventh in 2017 and is likely to reach the second place by 2040 [[4]]. Dementia caused an estimated $1 trillion in economic losses worldwide in 2018.…”

Section: Introductionmentioning

confidence: 99%

Trends in Prevalence and Disability-Adjusted Life-Years of Alzheimer’s Disease and Other Dementias in China from 1990 to 2019

Zhu¹,

Zheng²,

Chen³

et al. 2023

Neuroepidemiology

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Introduction: China has the largest population of people with dementia in the world and is estimated to have approximately a quarter of the entire population with dementia worldwide, bringing a heavy burden on the public and healthcare systems. We aimed to analyze the burden of Alzheimer’s disease and other dementias in China over the past three decades. Methods: The data on disease burden owing to Alzheimer’s disease and other dementias in China from 1990 to 2019 were extracted from the Global Burden of Disease (GBD) 2019 datasets. The estimated annual percentage changes (EAPCs) were calculated to assess the temporal trends, and the ratio of years lived with disability (YLDs) to disability-adjusted life-years (DALYs) was used as an indicator to evaluate the healthcare system. Result: In China, the overall age-standardized rates (ASRs) of the prevalence and DALYs of Alzheimer’s disease and other dementias increased from 1990 to 2019, and their EAPCs were 0.66 (95% confidence interval [CI], 0.57–0.75) and 0.26 (95% CI, 0.21–0.31), respectively. ASRs and the total number of dementia in females remained higher than in males, but the upward trend in ASRs among men was more pronounced than in women. The female-to-male ratio of the age-standardized DALY rate peaked in the 75–79 year age group in 2019 (female-to-male ratio of 1.32). The YLDs:DALYs ratio in China experienced a gradual increase and finally stayed above the global average since 2011. Conclusion: China has experienced a remarkably rising burden of dementia over the past three decades. The more significant burden of dementia was in females, but the potentially increasing burden of dementia in males cannot be underestimated.

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Section: Introductionmentioning

confidence: 99%

Trends in Prevalence and Disability-Adjusted Life-Years of Alzheimer’s Disease and Other Dementias in China from 1990 to 2019

Zhu¹,

Zheng²,

Chen³

et al. 2023

Neuroepidemiology

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“…With population aging, the prevalence of CI is increasing, posing a severe burden on global health care systems. 17 There are relative differences in the majority of CI in different regions, and the reasons for such differences may be related to the local environment, educational status, level of medical development, and lifestyle of the population. 18 The estimated prevalence of MCI in people aged 60 years or older in four major cities in Hebei Province in 2014 was 21.3%, compared with 20.1% in urban communities in China.…”

Section: Discussionmentioning

confidence: 99%

Cognitive Impairment and Associated Factors in Middle-aged and Elderly Individuals in Anhui Province, China

Cui

Zhai

et al. 2023

Preprint

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Background The prevalence rate of CI among middle-aged and elderly individuals in Anhui Province was 12.6%. Female sex, elderly age, family history, low educational status, current smoking status, sleep disorders, hypertension, stroke, and diabetes were shown to be risk factors for CI, while exercise was shown to be a protective factor. Methods From May to June 2022, a multistage, stratified cluster-sampling method was used to select 3200 middle-aged and elderly people over 45 years old in Anhui Province for a questionnaire survey, and the Chinese version of the Mini-Mental State Examination (MMSE) was used to assess cognitive function. SPSS 25.0 was used for univariate and multivariate analyses, and R software was used to establish and validate the nomogram. Results A total of 3059 valid questionnaires were included, of which 384 were from participants who were diagnosed with CI, and the prevalence rate was 12.6%. Multivariate logistic analysis showed that female sex, advanced age, family history, etc., were closely related to the occurrence of CI. The AUC values in the modeling and validation groups were 0.845 (95% CI: 0.822-0.868) and 0.868 (95% CI: 0.835-0.902), respectively, indicating that the predictive ability of the model was good. The Hosmer‒Lemeshow test suggested that the model had good goodness-of-fit, and the decision-curve evaluation nomogram had a high benefit within the threshold, which had a certain clinical importance.

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“…This disease affects memory, thinking, and the ability to perform daily activities. It may affect older people as a result of developing other diseases (e.g., hypertension, diabetes, obesity, smoking, alcoholism, and depression). , The Global Dementia Observatory (GDO), which is responsible for collecting data and an accountability mechanism for the global action plan on the public response to dementia from 2017 to 2025, provides support of around US$ 1.3 trillion in 2019 to cover the cost of care …”

Section: Introductionmentioning

confidence: 99%

“…1,2 The Global Dementia Observatory (GDO), which is responsible for collecting data and an accountability mechanism for the global action plan on the public response to dementia from 2017 to 2025, provides support of around US$ 1.3 trillion in 2019 to cover the cost of care. 2 Alzheimer's disease (AD) is the most common form of dementia and accounts for 60−70% of its cases. AD can rapidly progress from mild to severe within a short time frame.…”

Section: Introductionmentioning

confidence: 99%

First-Principles Approach for Assessing the Detection of Alzheimer’s Biomarkers Using Titanium Carbide MXenes

Kumar,

Bae,

Lee

et al. 2024

ACS Appl. Nano Mater.

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Alzheimer's disease (AD) is considered the most common neurodegenerative condition and is the main cause of dementia. AD progresses rapidly and is the major cause of death in the elderly population; thus, an early diagnosis is of vital importance. Medical research has successfully characterized a set of volatile organic compounds (VOCs) present in exhaled patient's breath to be considered as fingerprints of AD. The present work, for the first time, aims at computationally designing highly efficient nano-biosensors capable of detecting the VOC biomarkers. We apply density functional theory (DFT) to study the adsorption properties of three representative VOCs, namely, 2,3-dimethylheptane (23-DMH), butylated hydroxytoluene (BHT), and pivalic acid (PVA), versus four interfering air molecules (i.e., N 2 , O 2 , CO 2 , and H 2 O) on four different MXenes (i.e., thick Ti 3 C 2 T x and thin Ti 2 CT x MXenes, T x = O or S). All the molecules are found to exhibit physisorption interactions on the studied MXenes. Nevertheless, the energetic analysis shows clear selective adsorption of BHT on Ti 3 C 2 O 2 with an adsorption energy of −1.513 eV, which is desirable for practical sensing applications. Furthermore, distinct from all other VOCs and interfering air molecules, BHT oxidizes to the O passivation layer of MXenes with a charge transfer of +0.421e and induces magnetization of 0.467 μ B to transform the surface to become ferromagnetic. These changes are very promising to rectify the current−voltage characteristics and yield a high sensor response. We further performed thermodynamic analysis through the Langmuir adsorption model, which ensures the excellent adsorption performance of Ti 3 C 2 O 2 over a broad range of BHT concentrations at ambient temperature. Therefore, Ti 3 C 2 O 2 could be considered as highly sensitive and selective nano-biosensors toward the fingerprint VOCs of AD.

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The impacts of health insurance and resource on the burden of Alzheimer's disease and related dementias in the world population

Cited by 9 publications

References 43 publications

Trends in Prevalence and Disability-Adjusted Life-Years of Alzheimer’s Disease and Other Dementias in China from 1990 to 2019

Trends in Prevalence and Disability-Adjusted Life-Years of Alzheimer’s Disease and Other Dementias in China from 1990 to 2019

Cognitive Impairment and Associated Factors in Middle-aged and Elderly Individuals in Anhui Province, China

First-Principles Approach for Assessing the Detection of Alzheimer’s Biomarkers Using Titanium Carbide MXenes

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