The Impacts of Low-Level Laser Therapy – A Complementary Treatment in the Management of Side Effects After Implant Surgery

Safdari, Roya; Pouremadi, Narges; Talebzadeh, Ehsan; Mottaghi, Arash; Amini, Shahram; Hossienzadeh, Abolfath; Attar, Bijan Movahedian

doi:10.15171/jlms.2018.37

Cited by 7 publications

(1 citation statement)

References 23 publications

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“…There are more reports on red light than on green or blue light, and basic research has been carried out on its bioactivation effects 22) . Clinical studies in the dental field have reported that it promotes oral wound healing 23,24) and implant stability [25][26][27] . Blue light sources are used for the treatment of acne vulgaris, psoriasis, etc., and their results are often evaluated through mechanisms, such as bactericidal effects due to increased reactive oxygen species and induction of cell apoptosis 28) .…”

Section: Photobiomodulation Therapy (Pbmt)mentioning

confidence: 99%

Effect of Green LED Light Irradiation on Bone Marrow-Derived Osteoblast-Like Cells

Ogawa

Sugita

Hattori

et al. 2023

J. Hard Tissue Biology.

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In recent years, many reports have suggested that photobiomodulation therapy (PBMT) using laser or LED light has wound-healing effects and is effective for early osseointegration of implants. In addition, studies using LEDs often use red LED light with a wavelength of 600-900 nm. On the other hand, there are reports that shorter wavelength light sources, such as green with a wavelength of 500-570 nm, are more effective for cell proliferation. Therefore, we examined the wound-healing effect of PBMT by irradiating rat-derived osteoblast-like cells with green LED light. Osteoblast-like cells collected from rat femurs were cultured and irradiated four times with green LED light at 5.6 J/cm 2 for 16 seconds. Comparisons were made between a group irradiated with LED light, a group treated with fibroblast growth factor, a group irradiated with LED light and treated with fibroblast growth factor, and a control group. The wound healing effects were examined by evaluating cell proliferation activity, alkaline phosphatase (ALP) activity, and mineralization ability. LED irradiated cells showed significantly higher cell proliferative capacity than the control group, FGF group and LED + FGF group at 4.5 and 12 hours after irradiation. The ALP activity of the LED irradiated cells was considerably higher than those of the control group, FGF group and LED + FGF group, cells, 5 and 7 days after irradiation. The mineralization ability of LED irradiated cells was higher than those of the control group, FGF group and LED + FGF group 14 days after irradiation. Under the conditions of this study, irradiation of rat osteoblast-like cells with green LED light enhanced cell proliferation, ALP activity, and mineralization. This suggests that green LED light irradiation promotes wound healing.

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Section: Photobiomodulation Therapy (Pbmt)mentioning

confidence: 99%

Effect of Green LED Light Irradiation on Bone Marrow-Derived Osteoblast-Like Cells

Ogawa

Sugita

Hattori

et al. 2023

J. Hard Tissue Biology.

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Can Combining Low Level Laser Therapy With Computer Guided Flapless Piezosurgical Osteotomy Achieve a Painless Implant Surgery? Findings of Split Mouth Randomized Controlled Trial

Adly

Rasheed

et al. 2022

Journal of Evidence-Based Dental Practice

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Low-level laser therapy on soft tissue healing after implantation: a randomized controlled trial

Zou,

Zhang,

Jiang

et al. 2024

BMC Oral Health

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Background To explore the effect of low-level laser therapy (LLLT) on the healing of soft tissue around the implant after flap implantation and explore the possible mechanism. Methods A total of 58 patients who underwent implant surgery were enrolled, with a total of 70 implants. They were randomly divided into the LLLT group and the control group. The LLLT group underwent LLLT with Nd:YAG (Fotona, 1064 nm) immediately after surgery and on the 2nd and 3rd day in the surgical area, while the control group did not receive any intervention. Pain assessment was performed in the first 3 days after surgery. The weight of peri-implant crevicular fluid (PICF), modified sulcus bleeding index (mSBI), gingival index (GI), and the expression levels of tumor necrosis factor-α (TNF-α), and vascular endothelial growth factor (VEGF) on the 7th and 14th days after surgery were evaluated. Results On the first 3 days after surgery, the pain score of the LLLT group was significantly lower than that of the control group. On the 7th and 14th day after surgery, the PICF volume, mSBI, GI, and TNF-α levels of the LLLT group were lower than those of the control group. The VEGF levels in the LLLT group were significantly higher than that in the control group. Conclusions LLLT can promote the healing of the soft tissue after implantation, effectively relieve postoperative pain, improve clinical indicators, reduce TNF-α, and increase the expression level of VEGF, which is worthy of clinical application. Trial registration Retrospectively Registered Trials ChiCTR2400087562 (07/30/2024) Supplementary Information The online version contains supplementary material available at 10.1186/s12903-024-05258-7.

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The Impacts of Low-Level Laser Therapy – A Complementary Treatment in the Management of Side Effects After Implant Surgery

Cited by 7 publications

References 23 publications

Effect of Green LED Light Irradiation on Bone Marrow-Derived Osteoblast-Like Cells

Effect of Green LED Light Irradiation on Bone Marrow-Derived Osteoblast-Like Cells

Can Combining Low Level Laser Therapy With Computer Guided Flapless Piezosurgical Osteotomy Achieve a Painless Implant Surgery? Findings of Split Mouth Randomized Controlled Trial

Low-level laser therapy on soft tissue healing after implantation: a randomized controlled trial

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