The impacts of metabolic syndrome on the risk of severe urolithiasis

Fu, Qingsong; Xie, Linguo; Diao, Chengwen; Aizezi, Xierzhati; Liu, Xiaoyu; Liu, Chunyu

doi:10.1007/s00240-022-01328-z

Cited by 5 publications

(9 citation statements)

References 33 publications

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“…A lasted meta-analysis showed that Mets was associated with increased risk of developing nephrolithiasis and linear signi cant association between MetS components and nephrolithiasis were revealed [11]. Our previous study found that MetS is an independent risk factor for severe urolithiasis disease [12].…”

Section: Introductuonmentioning

confidence: 93%

“…The preoperative factors studied included age, sex, weight, presence of comorbidities such as diabetes, hypertension, and hyperlipidemia. All blood and urine samples were collected as previous described [12], serum calcium, magnesium, kalium, uric acid, creatinine, triglycerides(TG), high-density lipoprotein cholesterol (HDL-C) and urine culture were included.…”

Section: Data Collectionmentioning

confidence: 99%

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Metabolic Syndrome Differences between Unilateral and Bilateral Staghorn Renal Stones and the Impact on Outcome of Percutaneous Nephrolithotomy

Shen

Xie

Luo

et al. 2023

Preprint

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Purpose To evaluate the Metabolic syndrome(MetS) in patients with unilateral and bilateral staghorn calculus(SC) and compare the impact on the outcome of percutaneous nephrolithotomy(PCNL).Methods The patients who underwent PCNL for the treatment of SC were retrospectively reviewed between 2019–2022. SC were divided into unilateral and bilateral. The variables of the patients were calculated to evaluate the MetS difference between unilateral and bilateral SC and the impact on the outcome of PCNL.Results 1778 patients were received PCNL between 2019 and 2022, After screening computed tomography, A total of 379 patients with staghorn calculus, patients without follow-up and incomplete data were excluded, finaly 310 patients with SC were included. 84 with bilateral SC and 226 with unilateral. More higher body mass index, complete staghorn and metabolic syndrome were found in the patients with bilateral SC. Higher body mass index, hypertension, diabetes mellitus, hyperlipidemia, MetS were 62.58%, 44.84%, 21.94%, 60.65% and 27.42% in patients. 85 patients with MetS(+) resulted in higher rate of overall complication(Number(N)(%), 29(38.10) VS 54(23.89), p = 0.013) and comparable stone free rate with 225 MetS(-). Multivariable analysis confirmed that hyperlipidemia(p = 0.044, odds ratio[OR] = 1.991, 95% confidence interval[CI] 1.020–3.888) and MetS ( p = 0.005, OR = 2.427, 95%CI 1.316–4.477) were independent risk factors for overall complication.Conclusions MetS are strongly correlated with the formation of bilateral SC and is the core predictor in assessing overall complication for PCNL.

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Section: Introductuonmentioning

confidence: 93%

Section: Data Collectionmentioning

confidence: 99%

Metabolic Syndrome Differences between Unilateral and Bilateral Staghorn Renal Stones and the Impact on Outcome of Percutaneous Nephrolithotomy

Shen

Xie

Luo

et al. 2023

Preprint

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“…MS is associated with various metabolic disorders, including obesity (mainly abdominal obesity), fasting and postprandial hyperglycemia, hypertension, and dyslipidemia. In our previous report, the proportion of patients diagnosed with MS among urolithiasis patients was estimated at 29.9% (272/910) [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…In a retrospective study involving 52,184 patients, abnormal levels of blood lipids were found to correlate with an increased risk of kidney stones (hazard ratio, 2.2; 95% confidence interval,1.9–2.5; p < 0.001) [ 10 ]. Additionally, in our previous study, the proportion of patients accompanied by dyslipidemia among urolithiasis patients was estimated at 61.8% (562/910) [ 9 ]. This rate is much higher than the overall incidence of dyslipidemia in Chinese adults (≥ 35 years old), which stands at 34.7%.…”

Section: Introductionmentioning

confidence: 99%

Dysregulated palmitic acid metabolism promotes the formation of renal calcium-oxalate stones through ferroptosis induced by polyunsaturated fatty acids/phosphatidic acid

Wang,

Zhang,

Ren

et al. 2024

Cell. Mol. Life Sci.

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The pathogenesis of renal calcium-oxalate (CaOx) stones is complex and influenced by various metabolic factors. In parallel, palmitic acid (PA) has been identified as an upregulated lipid metabolite in the urine and serum of patients with renal CaOx stones via untargeted metabolomics. Thus, this study aimed to mechanistically assess whether PA is involved in stone formation. Lipidomics analysis of PA-treated renal tubular epithelial cells compared with the control samples revealed that α-linoleic acid and α-linolenic acid were desaturated and elongated, resulting in the formation of downstream polyunsaturated fatty acids (PUFAs). In correlation, the levels of fatty acid desaturase 1 and 2 (FADS1 and FADS2) and peroxisome proliferator-activated receptor α (PPARα) in these cells treated with PA were increased relative to the control levels, suggesting that PA-induced upregulation of PPARα, which in turn upregulated these two enzymes, forming the observed PUFAs. Lipid peroxidation occurred in these downstream PUFAs under oxidative stress and Fenton Reaction. Furthermore, transcriptomics analysis revealed significant changes in the expression levels of ferroptosis-related genes in PA-treated renal tubular epithelial cells, induced by PUFA peroxides. In addition, phosphatidyl ethanolamine binding protein 1 (PEBP1) formed a complex with 15-lipoxygenase (15-LO) to exacerbate PUFA peroxidation under protein kinase C ζ (PKC ζ) phosphorylation, and PKC ζ was activated by phosphatidic acid derived from PA. In conclusion, this study found that the formation of renal CaOx stones is promoted by ferroptosis of renal tubular epithelial cells resulting from PA-induced dysregulation of PUFA and phosphatidic acid metabolism, and PA can promote the renal adhesion and deposition of CaOx crystals by injuring renal tubular epithelial cells, consequently upregulating adhesion molecules. Accordingly, this study provides a new theoretical basis for understanding the correlation between fatty acid metabolism and the formation of renal CaOx stones, offering potential targets for clinical applications.

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“…Metabolic syndrome, a cluster of cardiometabolic risk factors including abdominal obesity, impaired glucose regulation, dyslipidaemia, and hypertension, is ultimately the result of a positive energy balance [1,6]. Growing evidence suggests that metabolic syndrome is closely related to urolithiasis, and that the risk of urinary stone formation increases with the number of metabolic syndrome traits [7][8][9][10][11]. A bidirectional association between metabolic syndrome and non-alcoholic fatty liver disease (NAFLD) has also been established [12].…”

Section: Introductionmentioning

confidence: 99%

Dietary weight loss strategies for kidney stone patients

Siener

Metzner

2023

World J Urol

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Purpose Overweight has been associated with an increased risk of incident and recurrent kidney stone disease. Weight reduction is the therapeutic consequence to decrease the risk of stone formation. This review examines the effectiveness of different weight loss strategies on weight reduction and cardiometabolic risk profile, with a particular focus on risk factors for urolithiasis. Methods A selective literature search was performed using PubMed and Cochrane library. Results Clinical evidence for the potential benefits of dietary weight loss strategies for kidney stone disease is limited. A conventional, energy-restricted diet may significantly induce weight loss and reduce urinary supersaturation of calcium oxalate in overweight individuals with or without a history of stone formation. The current data indicate that an energy-restricted diet with partial meal replacement may additionally decrease the relative supersaturation of uric acid and further improve the cardiometabolic risk profile, and, thus, may be a favourable option for overweight kidney stone patients. Studies on the Mediterranean and DASH diets on the association between weight loss and the risk of urinary stone formation are lacking. Conclusion An energy-restricted diet with or without meal replacement could be a promising weight loss strategy for overweight kidney stone patients. Further studies are needed to evaluate the impact of different weight loss strategies on urinary risk factors and cardiometabolic risk profile in urolithiasis.

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The impacts of metabolic syndrome on the risk of severe urolithiasis

Cited by 5 publications

References 33 publications

Metabolic Syndrome Differences between Unilateral and Bilateral Staghorn Renal Stones and the Impact on Outcome of Percutaneous Nephrolithotomy

Metabolic Syndrome Differences between Unilateral and Bilateral Staghorn Renal Stones and the Impact on Outcome of Percutaneous Nephrolithotomy

Dysregulated palmitic acid metabolism promotes the formation of renal calcium-oxalate stones through ferroptosis induced by polyunsaturated fatty acids/phosphatidic acid

Dietary weight loss strategies for kidney stone patients

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