The impacts of natural product miltirone and the CYP2D6 pharmacogenetic phenotype on fluoxetine metabolism
Xiaodan Zhang,
Qingqing Li,
Xinwu Ye
et al.
Abstract:Introduction: To study the effects of drug-induced CYP2D6 activity inhibition and genetic polymorphisms on fluoxetine metabolism, rat liver microsomes (RLMs) and SD rats were used to investigate the potential drug‒drug interactions (DDIs), and CYP2D6 http://muchong.com/t-10728934-1 recombinant baculosomes were prepared and subjected to catalytic reactivity studies.Methods and Results: All analytes were detected by ultraperformance liquid chromatography–tandem mass spectrometry (UPLC‒MS/MS). After screening for… Show more
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