The impaired tolerance of the recently infarcted rat heart to cardioplegic arrest: The protective effect of orotic acid

Munsch, Christopher; Williams, John F.; Rosenfeldt, Franklin

doi:10.1016/0022-2828(89)90713-x

Cited by 25 publications

(18 citation statements)

References 10 publications

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“…Thus, both orotic acid and its salt, orotate, have been shown to improve markedly the function of the heart in hypertrophy, infarction, global ischemia and related conditions [16][17][18][19]. The pharmacological effect of orotic acid is thought to rely on the activation of anaerobic metabolism through maintenance of glycogen stores, significant increase in protein synthesis, and nucleotide metabolism [20,21].…”

Section: Introductionmentioning

confidence: 99%

Myocardial Infarct Size-Limiting and Anti-Arrhythmic Effects of Mildronate Orotate in the Rat Heart

Vilšķe̅rsts

Liepinsh

Kuka

et al. 2009

Cardiovasc Drugs Ther

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Section: Introductionmentioning

confidence: 99%

Myocardial Infarct Size-Limiting and Anti-Arrhythmic Effects of Mildronate Orotate in the Rat Heart

Vilšķe̅rsts

Liepinsh

Kuka

et al. 2009

Cardiovasc Drugs Ther

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“…The procedure of coronary ligation in our hands produces an infarct of very predictable size [6,16,17]. In the current study a pilot group of coronary ligations produced infarcts of 35.5 ± 1.8% of ventricular weight.…”

Section: Critique Of the Studymentioning

confidence: 95%

“…We have previously shown in the rat and the dog that, compared with normal hearts, these energydepleted, recently infarcted hearts show reduced recovery from cardioplegic arrest [4,6,16,17]. We have shown that infarcted hearts enter cardioplegic arrest with depleted energy stores in the surviving myocardium, and that this may compromise recovery from arrest.…”

Section: Importance Of Metabolic Correction For Infarcted Hearts Priomentioning

confidence: 99%

“…In experimental studies [4,16,17] in recently infarcted rat or dog hearts undergoing cardioplegic arrest, orotic acid therapy produced a powerful cardioprotective effect. Treatment with orotate after recent infarction and before urgent surgery, followed by aspartate supplementation of the cardioplegic solution is a logical combination of two forms of metabolic supplementation, and is a therapy that we use in patients with recent infarction undergoing coronary bypass surgery at the Alfred Hospital.…”

Section: Importance Of Metabolic Correction For Infarcted Hearts Priomentioning

confidence: 99%

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Aspartate improves recovery of the recently infarcted rat heart after cardioplegic arrest

Rosenfeldt

Korchazhkina²,

Richards

et al. 1998

European Journal of Cardio-Thoracic Surgery

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Background:We have previously shown that aspartate improves the tolerance of normal hearts to cardioplegia. The aim of this st was to investigate whether aspartate is also beneficial in the recently infarcted heart. Methods: Myocardial infarction was produced in by left coronary artery ligation. Twenty hours later their hearts were perfused on an isolated working rat heart apparatus and underw cardioplegic arrest for 30 min at 37°C with or without 20 mM aspartate in the cardioplegic solution (n = 11 per group). Functional recov and myocardial high energy phosphate levels were measured at the end of arrest and after 30 min of reperfusion. Results: There was difference in pre-arrest pump function between the untreated and aspartate-treated groups. However, after reperfusion the aspartate gr generated more power (3.4 ± 0.2 mJ/s per g) than the untreated group (2.5 ± 0.3 mJ/s per g; P Ͻ 0.05) such that the percentage recovery pre-arrest power in the aspartate group (67.7 ± 3.5%) was greater than in the untreated group (53.6 ± 4.9%; P Ͻ 0.05). The aspartate gr also showed increases in aortic flow and myocardial oxygen consumption compared to the untreated group (P Ͻ 0.05). There were between-group differences in high energy phosphate levels at the end of arrest or after reperfusion. Conclusion: Aspartate impro functional recovery of the recently infarcted heart during cardioplegic arrest, and therefore has potential as a useful adjunct to myocard protection in patients with recent myocardial infarction undergoing cardiac surgery.

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“…15 We have also shown that supplementation with orotate improves the tolerance of the recently infarcted heart to global ischaemia and reduces the severity of post-ischaemic myocardial dysfunction and structural damage. 23 Thus, orotic acid may benefit energy depleted hearts prior to cardiac surgery.…”

Section: Our Study Used Four Key Metabolic Substances All Of Which Hmentioning

confidence: 99%

Pre-operative Preparation for Cardiac Surgery Utilising a Combination of Metabolic, Physical and Mental Therapy

Hadj

Esmore

Rowland

et al. 2006

Heart, Lung and Circulation

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The impaired tolerance of the recently infarcted rat heart to cardioplegic arrest: The protective effect of orotic acid

Cited by 25 publications

References 10 publications

Myocardial Infarct Size-Limiting and Anti-Arrhythmic Effects of Mildronate Orotate in the Rat Heart

Myocardial Infarct Size-Limiting and Anti-Arrhythmic Effects of Mildronate Orotate in the Rat Heart

Aspartate improves recovery of the recently infarcted rat heart after cardioplegic arrest

Pre-operative Preparation for Cardiac Surgery Utilising a Combination of Metabolic, Physical and Mental Therapy

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