The implementation of accreditation in a chemical laboratory

Cortez, L.

doi:10.1016/s0165-9936(99)00164-8

Cited by 16 publications

(10 citation statements)

References 14 publications

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“…Prior work in analytical chemistry and genomics 10 - 14 has demonstrated the benefits of standardized test sample efforts for testing the reproducibility of technology platforms. To address the question of reproducibility in LC-MS-based proteomics, 15 the Human Proteome Organization (HUPO) created a test samples working group to carry out a controlled study involving 27 different labs.…”

Section: Introductionmentioning

confidence: 99%

A HUPO test sample study reveals common problems in mass spectrometry–based proteomics

Bell¹,

Deutsch²,

Au³

et al. 2009

Nat Methods

335

303

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We carried out a test sample study to try to identify errors leading to irreproducibility, including incompleteness of peptide sampling, in LC-MS-based proteomics. We distributed a test sample consisting of an equimolar mix of 20 highly purified recombinant human proteins, to 27 laboratories for identification. Each protein contained one or more unique tryptic peptides of 1250 Da to also test for ion selection and sampling in the mass spectrometer. Of the 27 labs, initially only 7 labs reported all 20 proteins correctly, and only 1 lab reported all the tryptic peptides of 1250 Da. Nevertheless, a subsequent centralized analysis of the raw data revealed that all 20 proteins and most of the 1250 Da peptides had in fact been detected by all 27 labs. The centralized analysis allowed us to determine sources of problems encountered in the study, which include missed identifications (false negatives), environmental contamination, database matching, and curation of protein identifications. Improved search engines and databases are likely to increase the fidelity of mass spectrometry-based proteomics.

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Section: Introductionmentioning

confidence: 99%

A HUPO test sample study reveals common problems in mass spectrometry–based proteomics

Bell¹,

Deutsch²,

Au³

et al. 2009

Nat Methods

335

303

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“…They found the implementation improved systematic recording and control of the tasks, robustness of the traceability chain and external recognition of quality of the laboratory. Cortez (1999) found accredited laboratories had more satisfactory and less suspicious and unsatisfactory laboratory performances than non-accredited laboratories. Thus, they claimed accredited laboratories were more succesful than non-accredited laboratories.…”

Section: Literature Reviewmentioning

confidence: 85%

The Relationship Between ISO 17025 Quality Management System Accreditation and Laboratory Performance

Sadikoğlu¹,

Temur²

2012

Quality Management and Practices

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IntroductionInternational Organization for Standardization ISO 9000 is a general standard related to fundamentals of implementation of a quality management system. The aim of ISO 9000 is to implement quality management procedures by means of leadership, work instructions, documentation and record keeping. ISO 9000 standard does not determine the quality or performance level of the product or service. It deals with standardization of process management and improvement of an organization. The origin of ISO 9000 standards comes from harmonizing quality standards across nations (Heizer & Render, 2011;Goetsch & Davis, 2010).Laboratory accreditation assesses the competencies of all types of laboratories in terms of performing specific tests and calibrations. ISO and the international Electro-Technical Commission (IEC) introduced ISO/IEC 17025 standard due to the growing importance of accreditation and international recognition. The assessment of the facilities that calibrate and test equipment is crucial to monitor accuracy of measurement and testing (Beckett and Slay, 2011). ISO 17025 is a laboratory standard equivalent to more generic ISO 9000. The standard can be applied by all organizations performing tests and/or calibrations and it can harmonize laboratories worldwide (ISO-9000, 2010).

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“…The second one makes reference to including Good Laboratory Practices and the ISO 9000 certification as competition factors. Cortez (1999) speaks about the importance of setting a distinction between the certification and the accreditation for a www.intechopen.com laboratory, as the first one makes reference to the evaluation on the quality system's requirements, while the second one not only covers such aspect, but it also evaluates the laboratory's technical competency. In that way, the certification processes as well as the ones of accreditation are applied in testing and calibration laboratories, certification of quality and environmental systems, products certification, personnel and inspection.…”

Section: Metrology In Qualitymentioning

confidence: 99%