“…Organizational challenges like organizational culture and the support of high level management; human challenges like lack of trained and skilled personnel at health care centers in this field (Khoumbati et al, 2010), user attitudes, technology acceptance (Venkatesh et al, 2012;Cresswell et al, 2013) user characteristics like age, economic, social and educational status (Hardiker et al, 2011), threats to confidentiality and privacy, legal, ethical and administrative barriers, cost of system implementation and maintenance (Khoumbati et al, 2010), sufficient investment (Lucas, 2008), poor design and implementation, lack of system interoperability with electronic health records and other IT tools (Lawler et al, 2011), decrease in face to face communication between doctor and patient (Lluch, 2011), failure to meet targets (Lucas, 2008), virtual information control (While, 2011), ill-functioning of system that leads to medical errors and negative effects on care outcomes, patients and personnel (Nykänen et al, 2011), defining proper strategy to select best actions (Alonso et al, 2003), technological barriers such as lack of ICT infrastructure (Cripps et al, 2011) ,developing flexible, extensible and open architecture platform, knowledge management based on MAS to ensure knowledge currency (Bhat et al, 2010); design challenges such as robustness, efficiency, and communication challenges in cooperation between agents (Kostiadis et al, 2000), applying appropriate ontology e.g. GALEN, UMLS, SNOMED in order to facilitate and accelerate retrieval and integration of health information and effective communication in systems based on agent technology (Volot et al, 1997;Safdari et al, 2009;OpenGALEN, 2013), and standards for data exchange between MAS and related tools .…”