Introduction: A systematic review was carried out to determine and address the employment-related barriers encountered by persons with visual impairment. The existing database has been analyzed to summarize employment-related issues, facilitate support, and ensure rehabilitation and equal participation in employment. Methods: Fourteen peer-reviewed publications in more than 13 countries from 1998 to 2021 that met the criteria to address employment issues were selected to summarize workplace-related barriers, workplace experience, and assistive technology usage. A three-point rating scale was used to evaluate the studies based on the number of employment-related issues they emphasized. Results: The findings were drawn thematically and suggested that (a) various workplace-related issues, including transportation, (b) the employer's intention to hire, and (c) lack of assistive technology are the most crucial barriers to employment. Discussions: The article identified the barriers to employment of persons with visual impairment from the existing literature and discussed the significant issues. Society needs to support the inclusion of each individual and ensure equal participation. Implications for the Practitioners: The review will enable rehabilitation professionals to get an insight into the issues and risk factors related to the employment of persons with visual impairment. This will allow the professionals to work out strategies to address the same.