The Implication of Aquaporin-9 in the Pathogenesis of Preterm Premature Rupture of Membranes

Abstract

Objective This study aimed to detect aquaporin-9 (AQP9) concentrations in the serum of patients with preterm premature rupture of membranes (PPROM) and compare them with the healthy control group with intact membranes. Material and methods We conducted this prospective case-control study from January 2020 to June 2020. Of the 80 pregnant patients included in the study, we enrolled 42 singleton pregnant patients with PPROM as the study group and 43 healthy gestational age-, and body mass index (BMI)-matched healthy pregnant women with intact fetal membranes as the control group. We compared demographic and clinical characteristics, complete blood count and biochemical parameters, and serum AQP9 concentrations of the participants. We constructed an ROC curve to illustrate the sensitivity and specificity performance characteristics of AQP9 and calculated a cutoff value by using the Youden index. Results Maternal serum AQP-9 concentrations were significantly higher in patients with PPROM (804.46±195.63 pg/mL) compared to the healthy pregnant women in the control group (505.97±68.89 pg/mL, p<0.001). When we examine the area under the ROC curve (AUC), the AQP-9 value can be reflected as a statistically significant parameter for diagnosing PPROM. According to the Youden index, a 654.78 pg/mL cut-off value of AQP-9 can be utilized to diagnose PPROM with 80.5% sensitivity and 100% specificity. Conclusion Maternal serum AQP9 concentrations were significantly higher in PPROM patients than healthy pregnant women with an intact membrane. We suggest that AQP9 might be an essential biomarker of the inflammatory process and energy homeostasis in PPROM.

ICTP concentration in cervical-vaginal fluid as a potential marker of membrane collagen degradation before labor

“…Whereas Behram et al showed a relationship between elevated levels of Il-22 and PROM [27]. A similar relationship was demonstrated for Aquaporin-9 [28].…”

Visual Analytics for Robust Investigations of Placental Aquaporin Gene Expression in Response to Maternal SARS-CoV-2 Infection

“…Considering that oxygen modulates placenta development [40] and oxygen tension could modulate AQP9 expression in the human placenta [41], there is need for further research on SARS-CoV-2 and other microbial infection-induced changes to the expression of AQP9 in placenta cell types. Additional reasons for further research on AQP9 in placenta structure, function, and development include the role of AQP9 in (1) preterm premature rupture of membrane (PPROM) [88], (2) early-onset pre-eclampsia [89], and (3) recurrent spontaneous abortion [65].…”

The Effect of Levothyroxine Treatment on Maternal and Perinatal Outcomes in Pregnant Women With Subclinical Hypothyroidism: A 5-Year Retrospective Study at a Tertiary Care Hospital in Turkey

“…LBW was considered when it was below 2500 g. Births before 37 weeks of gestation were termed as premature births. Rupture of membranes before 37 th gestational week was designated as PPROM [13]. Pregnant women with gestational diabetes mellitus [14] who had a positive oral glucose tolerance test were excluded from the study, but pregnant women with placenta previa [15] were included.…”