The implication of gut microbiota in recovery from gastrointestinal surgery

Zheng, Zhipeng; Hu, Yingnan; Tang, Jingyi; Xu, Wei; Zhu, Weihan; Zhang, Wei

doi:10.3389/fcimb.2023.1110787

Cited by 19 publications

(15 citation statements)

References 136 publications

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“…Recent studies have suggested that Prevotellaceae could be associated with intestinal inflammation (Elinav et al , 2011). Lachnospiraceae plays a vital role in reducing oxidative stress and preventing inflammation (Zhang et al , 2023). It has been proposed that the Lactobacillaceae mixture improved intestinal health in mice with Type 2 diabetes by alleviating inflammation in the gut (Li et al , 2023).…”

Section: Discussionmentioning

confidence: 99%

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Causal link between gut microbiome and schizophrenia: a Mendelian randomization study

Zeng,

Zhang,

Wang

2024

Psychiatric Genetics

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Objective Some observational studies have shown that gut microbiome is significantly changed in patients with schizophrenia. We aim to identify the genetic causal link between gut microbiome and schizophrenia. Methods A two-sample Mendelian randomization (MR) study was used to evaluate the causal link between gut microbiome and schizophrenia with 28 gut microbiome-associated genetic instrumental variants chosen from recent MR reports and the largest schizophrenia genome-wide association studies (8-Apr-22 release). Results Inverse variance weighted method showed that genetically increased Bacteroidales_S24-7 (per SD) resulted in increased risk of schizophrenia (OR = 1.110, 95% CI: [1.012–1.217], P = 0.027). Similarly, genetically increased Prevotellaceae promoted schizophrenia risk (OR = 1.124, 95% CI: [1.030–1.228], P = 0.009). However, genetically increased Lachnospiraceae reduced schizophrenia risk (OR = 0.878, 95% CI: [0.785–0.983], P = 0.023). In addition, schizophrenia risk was also suppressed by genetically increased Lactobacillaceae (OR = 0.878, 95% CI: [0.776–0.994], P = 0.040) and Verrucomicrobiaceae (OR = 0.860, 95% CI: [0.749–0.987], P = 0.032). Finally, we did not find any significant results in the causal association of other 23 gut microbiome with schizophrenia. Conclusion Our analysis suggests that genetically increased Bacteroidales_S24-7 and Prevotellaceae promotes schizophrenia risk, whereas genetically increased Lachnospiraceae, Lactobacillaceae, and Verrucomicrobiaceae reduces schizophrenia risk. Thus, regulation of the disturbed intestinal microbiota may represent a new therapeutic strategy for patients with schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Causal link between gut microbiome and schizophrenia: a Mendelian randomization study

Zeng,

Zhang,

Wang

2024

Psychiatric Genetics

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“…The relationship between intestinal flora and wound recovery following CRC surgery is a subject of growing importance, especially considering the increase in surgical interventions for CRC and the critical role that the gut microbiota plays in overall health. 21 , 22 , 23 …”

Section: Discussionmentioning

confidence: 99%

Promoting wound recovery through stable intestinal flora: Reducing post‐operative complications in colorectal cancer surgery patients

Chen,

Wang,

2023

International Wound Journal

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In recent years, the relationship between intestinal flora and post‐operative recovery, particularly in colorectal cancer (CRC) surgery patients, it has been hypothesized that intestinal flora stability influences wound healing, reduces complications and improves overall recovery outcomes after surgical interventions. This study examined the relationship between intestinal flora stability and post‐operative recovery in patients undergoing CRC surgery. Between May 2020 and 2023, 80 CRC patients from our hospital's Colorectal Surgery Department were enrolled. A random number table was used to divide them into two categories. Both groups were subjected to distinct gastrointestinal preparation protocols. Indicators of clinical therapeutic effect, intestinal flora balance following surgery, post‐operative complications and quality of life were evaluated. The observation group, which adhered to a distinct gastrointestinal regimen, demonstrated a statistically significant improvement in post‐operative outcomes, with a clinical effectiveness rate of 97.5% compared to the control group's 75%. In addition, the observation group had a lower incidence of intestinal flora imbalance following surgery than the control group. The observation group had lower incidences of intestinal obstruction, infection, anastomotic leakage, incisional tumour implantation and delayed diarrhoea. Using the KPS score and the BMI, post‐treatment assessments of the observation group's quality of life revealed significant enhancements in comparison to the control group. Additionally, wound healing rates were superior in the observation group, with a correlation between stable intestinal flora and decreased wound infection rates. The type of post‐operative diet influenced the stabilization of the gut flora, with a high‐fibre diet producing superior results in both groups. The stability of intestinal flora influences the post‐operative rehabilitation of patients undergoing CRC surgery favourably. Appropriate bowel preparation and dietary considerations can reduce post‐operative complications, improve wound healing rates and enhance overall quality of life.

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“…In the early stages of cancer, surgery is commonly used as a treatment method and significantly impacts patient microbiota, especially the gut microbiota 196 . Research has shown that in patients undergoing tumor surgery, the use of preoperative antibiotics may lead to a reduction in gut microbial diversity and the growth of pathogenic bacteria, potentially resulting in complications such as increased gut permeability 197 , 198 . Modulating the gut microbiota can be considered a potential strategy to alleviate this issue.…”

Section: Questioning the Impact Of The Gut Microbiota On Cancer Treat...mentioning

confidence: 99%

Role of the gut microbiota in tumorigenesis and treatment

Liu,

Yang,

Pan

et al. 2024

Theranostics

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The gut microbiota is a crucial component of the intricate microecosystem within the human body that engages in interactions with the host and influences various physiological processes and pathological conditions. In recent years, the association between dysbiosis of the gut microbiota and tumorigenesis has garnered increasing attention, as it is recognized as a hallmark of cancer within the scientific community. However, only a few microorganisms have been identified as potential drivers of tumorigenesis, and enhancing the molecular understanding of this process has substantial scientific importance and clinical relevance for cancer treatment. In this review, we delineate the impact of the gut microbiota on tumorigenesis and treatment in multiple types of cancer while also analyzing the associated molecular mechanisms. Moreover, we discuss the utility of gut microbiota data in cancer diagnosis and patient stratification. We further outline current research on harnessing microorganisms for cancer treatment while also analyzing the prospects and challenges associated with this approach.

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The implication of gut microbiota in recovery from gastrointestinal surgery

Cited by 19 publications

References 136 publications

Causal link between gut microbiome and schizophrenia: a Mendelian randomization study

Causal link between gut microbiome and schizophrenia: a Mendelian randomization study

Promoting wound recovery through stable intestinal flora: Reducing post‐operative complications in colorectal cancer surgery patients

Role of the gut microbiota in tumorigenesis and treatment

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