The implications of centrosomal RNA

Inter-dependent Centrosomal Co-localization of the cen and ik2 cis-Natural Antisense mRNAs in Drosophila

“…Several studies in different organisms have characterized mRNAs that are specifically localized to mitotic structures (Alliegro, 2008;Alliegro and Alliegro, 2008;Blower et al, 2007;Groisman et al, 2000;Kingsley et al, 2007;Kowanda et al, 2016;Lambert and Nagy, 2002;Lé cuyer et al, 2007;Lerit and Gavis, 2011;Sharp et al, 2011), leading to different models of the potential functional roles of this process. For example, work in Ilyanassa embryos showed that the asymmetric localization of mRNAs to centrosomes provides an elegant mechanism to drive the selective inheritance of specific transcripts between daughter cells during embryonic cleavage divisions (Kingsley et al, 2007;Lambert and Nagy, 2002).…”

Association of the mammalian transcriptional regulator Kaiso with centrosomes and the midbody

“…To this end, it is important to mention that centrosomes contain RNA. 13 Further, it has long been suggested that at least some transcription factors can also bind RNA and that this binding may be functionally relevant. 14,15 In contrast to many other proteins targeted to the centrosomes during mitosis only (see below), a portion of Kaiso remains associated with the centrosomes during interphase (Fig.…”

Teachings from the egg: New and unexpected functions of RNAs

“…Additional proof of the presence of RNAs in the cell division apparatus comes from recent studies of centrosomal RNA in Spisula oocytes (Alliegro, 2008;Alliegro and Alliegro, 2008). In all animal cells, the centrosome (composed of a pair of centrioles embedded in a pericentriolar matrix) functions as the MTOC.…”

“…The screening of the library of RNA extracted from isolated centrosomes of Spisula oocytes showed the presence of a subset of centrosome-associated RNAs (cnRNAs), which may be involved in the nucleation of microtubules and the mitotic spindle assembly (Alliegro, 2008;Alliegro and Alliegro, 2008).…”