The number of female entrepreneurs is growing around the globe. The rate of women's entrepreneurship in Africa is higher than in any other region of the world but no studies have focused on North Sudan. We investigate female entrepreneurs in North Sudan by addressing these questions: (1) What are the major challenges North Sudanese female entrepreneurs face in (a) venture startup, and (b) running their businesses, (2) What are the main support sources enabling North Sudanese female entrepreneurs' (a) venture startup, and (b) successful management of their new ventures?, and (3) Is there family involvement in the North Sudanese female entrepreneurs' businesses; and if so, how? Personal issues, management skills, and obtaining financing are challenges while sources of support include schooling and previous work experience, moral support, and institutional support. Implications are discussed.