The Importance of Accurate Tumor Measurements and Staging in Oncologic Imaging: Impact on Patients’ Health

Spinnato, Paolo

doi:10.1016/j.acra.2021.01.012

Cited by 6 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results encourage us to consider in the conventional MRI analysis tumor proximity to major vessels. Tumor-vascular closeness must be evaluated, quantified, and considered among the other already known MRI features related to patients’ prognosis, which include peritumoral enhancement, signs of necrosis, signal intensity inhomogeneity, ill-defined borders, and signs of infiltrations [ 27 , 28 , 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Vascular Proximity Increases the Risk of Local Recurrence in Soft-Tissue Sarcomas of the Thigh—A Retrospective MRI Study

Sambri

Caldari

Montanari

et al. 2021

Cancers

Self Cite

View full text Add to dashboard Cite

The aim of this study was to establish the prognostic effects of the proximity of the tumor to the main vessels in patients affected by soft tissue sarcomas (STS) of the thigh. A total of 529 adult patients with deeply seated STS of the thigh and popliteal fossa were included. Vascular proximity was defined on MRI: type 1 > 5 mm; type 2 ≤ 5 mm and >0 mm; type 3 close to the tumor; type 4 enclosed by the tumor. Proximity to major vessels type 1–2 had a local recurrence (LR) rate lower than type 3–4 (p < 0.001). In type 4, vascular by-pass reduced LR risk. On multivariate analysis infiltrative histotypes, high FNLCC grade, radiotherapy administration, and type 3–4 of proximity to major vessels were found to be independent prognostic factors for LR. We observed an augmented risk of recurrence, but not of survival as the tumor was near to the major vessels. When major vessels were found to be surrounded by the tumor on preoperative MRI, vascular resection and bypass reconstruction offered a better local control.

show abstract

Section: Discussionmentioning

confidence: 99%

Vascular Proximity Increases the Risk of Local Recurrence in Soft-Tissue Sarcomas of the Thigh—A Retrospective MRI Study

Sambri

Caldari

Montanari

et al. 2021

Cancers

Self Cite

View full text Add to dashboard Cite

show abstract

“…Given the malignant nature of ASPS, the identification of peculiar ASPS imaging features is consequently related to the possibility of achieving an early diagnosis with timely patient referral to sarcoma centers for prompt treatment [7]. As for other malignancies, the size of the tumor remains a key element that correlates with prognosis, even for this rare and aggressive subtype [34,35]. Indeed, in our series, a maximum diameter at diagnosis greater than 5 cm was always associated with metastatic disease at baseline staging.…”

mentioning

confidence: 99%

Imaging Features of Alveolar Soft Part Sarcoma: Single Institution Experience and Literature Review

Spinnato,

Papalexis,

Colangeli

et al. 2023

Clinics and Practice

Self Cite

View full text Add to dashboard Cite

Alveolar soft part sarcoma (ASPS) is an extremely rare and aggressive soft-tissue sarcoma (STS) subtype with poor prognosis and limited response to radiation therapy and chemotherapy. Prompt recognition and referral to sarcoma centers for appropriate management are crucial for patients’ survival. The purpose of this study was to report ASPS pre-treatment imaging features and to examine the existing literature on this topic. Twelve patients (7 women, 5 men—mean age 27.1 ± 10.7 years) were included from our single-center experience. Ultrasonography (US), computed tomography (CT), and magnetic resonance imaging (MRI) available were reviewed according to an analysis grid incorporating features from the latest research on STS. Clinical, histological, and outcome data were collected. MRI was available in 10 patients (83.3%), US in 7 patients (58.3%), and CT in 3 patients (25%). Mean longest tumor diameter was 7.6 ± 2.9 cm, and all tumors were deeply seated. Large peritumoral feeding vessels were systematically found and identified on ultrasonography (7/7), MRI (10/10), and CT (3/3). US revealed a well-defined heterogeneous hypoechoic pattern, with abundant flow signals in all patients (7/7). In all patients, MRI showed mildly high signal intensity (SI) on T1-WI and high SI on T2-WI and peritumoral edema. Moreover, flow-voids (due to arteriosus high-flow) into the peritumoral/intratumoral feeding vessels were detected in the MRI fluid-sensitive sequences of all patients. At baseline, whole-body contrast-enhanced CT revealed metastases in 8/12 (66.7%) patients. A pre-treatment longest diameter > 5 cm was significantly associated with distant metastases at diagnosis (p = 0.01). A maximum diameter > 5 cm represents a risk of metastatic disease at diagnosis (odds ratio = 45.0000 (95% CI: 1.4908—1358.3585), p = 0.0285). In the comprehensive literature review, we found 14 articles (case series or original research) focusing on ASPS imaging, with a total of 151 patients included. Merging our experience with the data from the existing literature, we conclude that the hallmark of ASPS imaging at presentation are the following characteristics: deep location, a slight hyperintense MRI SI on T1-WI and a hyperintense SI on T2-WI, numerous MRI flow voids, high internal vascularization, and large peritumoral feeding vessels.

show abstract

Magnetic resonance imaging of soft tissue sarcoma: features related to prognosis

Scalas

Parmeggiani

Martella

et al. 2021

Eur J Orthop Surg Traumatol

View full text Add to dashboard Cite

The Importance of Accurate Tumor Measurements and Staging in Oncologic Imaging: Impact on Patients’ Health

Cited by 6 publications

References 13 publications

Vascular Proximity Increases the Risk of Local Recurrence in Soft-Tissue Sarcomas of the Thigh—A Retrospective MRI Study

Vascular Proximity Increases the Risk of Local Recurrence in Soft-Tissue Sarcomas of the Thigh—A Retrospective MRI Study

Imaging Features of Alveolar Soft Part Sarcoma: Single Institution Experience and Literature Review

Magnetic resonance imaging of soft tissue sarcoma: features related to prognosis

Contact Info

Product

Resources

About