Animals and their derivatives have been used for a wide range of purposes, including human consumption, clothing, tools, medicinal and magical-religious purposes, for most of human history, and as pets more recently. We reviewed the scientific literature and, using 134 references, provided an overview of how 400 species of skinks (23% of skink diversity) are used in the context of ethnozoology, especially as related to international and domestic trade and any cultural significance. Except for 10 species, all records of skinks involve domestic or international trade. Body weight, various activity pattern traits, and various microhabitats were found to be positive predictors of documented human use. In contrast, species found in less accessible microhabitats, such as semi-aquatic species, showed reduced odds of an ethnozoological role. A more comprehensive examination of trading patterns, cultural significance, or any other human use of skinks currently appears to be impossible, simply due to a lack of necessary information. In addition, data related to functional traits of skinks or a general understanding about the factors that influence skink usage or cultural significance are scarce or absent. We conclude that our understanding of factors that may influence human use of lizards in general and skinks in particular needs to be improved to create more effective species conservation and environmental education outcomes.