The importance of biological factors (bcl-2, bax, p53, PCNA, MI, HPV and angiogenesis) in invasive cervical cancer

Tjalma, Wiebren; Weyler, Joost; Bogers, Johannes; Pollefliet, C.; Baay, Marc; Goovaerts, G; Vermorken, Jan B.; Dam, Peter van; Marck, Eric A. Van; Buytaert, Ph.

doi:10.1016/s0301-2115(00)00541-8

Cited by 74 publications

(50 citation statements)

References 46 publications

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“…pro-apoptotic versus anti-apoptotic bcl-family proteins determines the inherent susceptibility of a given cell that responds to apoptotic signals. The pro-apoptotic Bax and anti-apoptotic bcl-2 are important proteins of bcl-2 family and the ratio of bcl-2/Bax play a critical role in the regulation of apoptosis [16] .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of anti–apoptotic activity of different dietary antioxidants in renal cell carcinoma against hydrogen peroxide

Rai

Mangal

Sahu

et al. 2011

Asian Pacific Journal of Tropical Biomedicine

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Section: Introductionmentioning

confidence: 99%

Evaluation of anti–apoptotic activity of different dietary antioxidants in renal cell carcinoma against hydrogen peroxide

Rai

Mangal

Sahu

et al. 2011

Asian Pacific Journal of Tropical Biomedicine

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“…The Bcl-2 gene family is generally considered as the important regulator of apoptosis. As described in detail previously [38], the inherent susceptibility of the reaction to the apoptotic signals for cells is determined by the changes in the expression of the anti-apoptotic proteins and pro-apoptotic proteins of the Bcl-2 gene family. The anti-apoptotic Bcl-2 proteins and the pro-apoptotic Bax are the significant proteins in the Bcl-2 family, and the rate of Bcl-2/Bax is crucial to apoptosis cell death [38].…”

Section: Discussionmentioning

confidence: 99%

“…As described in detail previously [38], the inherent susceptibility of the reaction to the apoptotic signals for cells is determined by the changes in the expression of the anti-apoptotic proteins and pro-apoptotic proteins of the Bcl-2 gene family. The anti-apoptotic Bcl-2 proteins and the pro-apoptotic Bax are the significant proteins in the Bcl-2 family, and the rate of Bcl-2/Bax is crucial to apoptosis cell death [38]. Bcl-2 from the mitochondria inhibits the release of cytochrome c, and Bax inactivates the caspase cascade and thus prevents stress-induced apoptosis [39,40].…”

Section: Discussionmentioning

confidence: 99%

Enhancement of Apoptosis by Titanium Alloy Internal Fixations During Microwave Treatments for Fractures: An Animal Study

Bai

2015

Archives of Physical Medicine and Rehabilitation

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“…malignant mesothelioma, invasive cervical carcinoma and colorectal carcinoma). Angiogenesis and its prognostic potential are described in detail for the three lesions, which provides data that can be used to compare with our results [36][37][38][39][40][41][42][43]. Besides the aforementioned parameters, we have also calculated the more 'classical parameters' like IMD, vessel area, lumen and perimeter, which were used together with some clinical data, as 'internal references'.…”

Section: Introductionmentioning

confidence: 99%

Determination of Tumour Prognosis Based on Angiogenesis-related Vascular Patterns Measured by Fractal and Syntactic Structure Analysis

et al. 2004

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ABSTRACT:Aims: Intratumoural micro-vessel density (IMD) has recently been shown to be a valuable prognostic tool in many tumours. Yet, IMD does not take into account the spatial arrangement of the vessels, therefore only partly reflecting the angiogenic situation. In order to describe contextual vascular relationships more accurately, we have used fractal and syntactic structure analysis (SSA) based on computerised image processing to quantify micro-vascular hot spots. Materials and methods:The parametric performance in prediction of patients' outcome was evaluated by univariate analysis and compared with manually obtained IMDs, whereas an automated K-nearest-neighbour (KNN) classifier searched most discriminative parametric combinations. The method is based on analysis of vascular 'hot-spots' of paraffin-embedded tissue sections of invasive cervical carcinoma, colorectal carcinoma and malignant mesothelioma. Results: For all three cancers, prediction of prognosis based on SSA yielded in general much higher recognition scores compared with IMD or fractal dimension. Survival of cervical carcinoma was mostly correlated with clinical data, with the vascular permeation being the only parameter with independent value. Prognosis of colorectal carcinoma is best described by SSA, completed with IMD, indicating an inverse correlation of survival time with a more irregular pattern and a slight increase in vessel number. For mesothelioma, we found a strong correlation with SSA and patients' outcome, with two SSA-parameters having independent prognostic value. Conclusions: The more accurate angiogenic description obtained with SSA may be useful for further exploitation as a prognosticator in a general diagnostic pathology service.

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The importance of biological factors (bcl-2, bax, p53, PCNA, MI, HPV and angiogenesis) in invasive cervical cancer

Cited by 74 publications

References 46 publications

Evaluation of anti–apoptotic activity of different dietary antioxidants in renal cell carcinoma against hydrogen peroxide

Evaluation of anti–apoptotic activity of different dietary antioxidants in renal cell carcinoma against hydrogen peroxide

Enhancement of Apoptosis by Titanium Alloy Internal Fixations During Microwave Treatments for Fractures: An Animal Study

Determination of Tumour Prognosis Based on Angiogenesis-related Vascular Patterns Measured by Fractal and Syntactic Structure Analysis

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