We thank the authors for their response to our article. Although we acknowledge that there are many other risk factors that may contribute to acute kidney injury (AKI), we believe that our study contributes to the growing body of knowledge of potential complications associated with performing 2-stage exchange arthroplasty for the treatment of periprosthetic joint infection (PJI). In this study, we evaluated common risk factors and potentially modifiable factors that may be addressed prior to or during the first-stage spacer placement for PJI treatment. Thus, although it would be ideal to evaluate every possible risk factor associated with AKI, this study still provides valuable information that orthopedic surgeons can use when treating PJI patients undergoing 2-stage exchange arthroplasty.The authors note that preoperative medications were not included in the multivariable logistic regression analysis. In our study, we evaluated comorbidities such as chronic hypertension, diabetes mellitus, chronic kidney disease, and cardiovascular disease, which are very prevalent in the total joint arthroplasty patient population. It is assumed that patients who are taking perioperative angiotensin receptor blockers or angiotensin-converting enzyme inhibitors are on these medications to treat the comorbidities that we evaluated. Thus, we indirectly determined that these preoperative medications are most likely risk factors for developing postoperative AKI based on the comorbidities studied. Future studies evaluating the risk of developing AKI by investigating these specific medications could be performed to validate this.The authors also indicated that AKI is associated with postoperative anemia and stated that we did not take postoperative hemoglobin levels into consideration. However, we found that hemoglobin drop (the difference between preoperative and postoperative hemoglobin levels) was an independent predictor of AKI (Table 5). Thus, the findings from our study corroborate with other studies in the literature, and orthopedic surgeons should be cognizant of minimizing blood loss during the first-stage surgery by utilizing meticulous surgical dissection, electrocautery, and medications such as tranexamic acid.Finally, we acknowledge that data about blood transfusions and hypotension requiring administration of vasopressors would greatly enhance the analysis of the study. Of note, there were no cases of sepsis or acute myocardial infarction in our study population during the first 48 hours of the hospital stay where we assessed AKI in patients. It is imperative to conduct further studies on this topic to highlight that performing 2-stage exchange arthroplasty in PJI patients is not benign and that associated complications, such as AKI, may have significant consequences.