The importance of calprotectin levels in obstructive sleep apnea syndrome severity

Torun, Mümtaz Taner; Unver, Ethem; Yalçın, Yusuf; Kanmaz, Lutfi; Seçkin, Ender

doi:10.1080/03007995.2017.1383890

Cited by 3 publications

(3 citation statements)

References 31 publications

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“…It is known that increased levels of several inflammatory mediators play roles in obstructive sleep apnea syndrome (OSAS). Torun et al measured serum CLP levels in a small cohort of OSAS patients and found no significant difference in CLP between the OSAS and normal groups [193]. However, significantly increased CLP values were determined in severe OSAS patients when compared to the other OSAS groups [193].…”

Section: Clp In Obstructive Sleep Apnea Syndromementioning

confidence: 99%

“…Torun et al measured serum CLP levels in a small cohort of OSAS patients and found no significant difference in CLP between the OSAS and normal groups [193]. However, significantly increased CLP values were determined in severe OSAS patients when compared to the other OSAS groups [193]. More recently, Kum et al confirmed that the serum CLP level could be used as an OSA severity indicator [194].…”

Section: Clp In Obstructive Sleep Apnea Syndromementioning

confidence: 99%

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Calprotectin in Lung Diseases

Kotsiou

Papagiannis

Papadopoulou

et al. 2021

IJMS

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Calprotectin (CLP) is a heterodimer formed by two S-100 calcium-binding cytosolic proteins, S100A8 and S100A9. It is a multifunctional protein expressed mainly by neutrophils and released extracellularly by activated or damaged cells mediating a broad range of physiological and pathological responses. It has been more than 20 years since the implication of S100A8/A9 in the inflammatory process was shown; however, the evaluation of its role in the pathogenesis of respiratory diseases or its usefulness as a biomarker for the appropriate diagnosis and prognosis of lung diseases have only gained attention in recent years. This review aimed to provide current knowledge regarding the potential role of CLP in the pathophysiology of lung diseases and describe how this knowledge is, up until now, translated into daily clinical practice. CLP is involved in numerous cellular processes in lung health and disease. In addition to its anti-microbial functions, CLP also serves as a molecule with pro- and anti-tumor properties related to cell survival and growth, angiogenesis, DNA damage response, and the remodeling of the extracellular matrix. The findings of this review potentially introduce CLP in daily clinical practice within the spectrum of respiratory diseases.

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Section: Clp In Obstructive Sleep Apnea Syndromementioning

confidence: 99%

Section: Clp In Obstructive Sleep Apnea Syndromementioning

confidence: 99%

Calprotectin in Lung Diseases

Kotsiou

Papagiannis

Papadopoulou

et al. 2021

IJMS

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“…Calprotectin level is elevated in patients with moderate and severe obstructive sleep apnea [ 53 ]). Similarly, Torun’s study showed that it could be used as a marker for the severity of obstructive sleep apnea syndrome [ 54 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

Calprotectin, Biomarker of Depression in Patients with Inflammatory Bowel Disease?

et al. 2023

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Background and Objectives: Calprotectin is a marker for intestinal inflammation. Recent research suggests a link between inflammation and depression. This study assessed the association between the levels of calprotectin in patients from South-Eastern Europe and the severity of depression, anxiety, and quality of life. Materials and Methods: This cross-sectional study included 30 confirmed patients with Crohn’s disease (CD) and ulcerative colitis (UC) who were assessed using clinical interviews for determining the severities of mental disorders (i.e., depression severity—PHQ-9, anxiety—GAD-7) and the quality of life (EQ-5D). Stool samples were collected from all participants for measuring their levels of calprotectin. Results: The level of calprotectin is correlated with PHQ-9 (ρ = 0.416, p = 0.022) and EQ-5D (ρ = −0.304, p = 0.033) but not with GAD 7 (ρ = 0.059, p = 0.379). Calprotectin levels in patients with mild, moderate, and moderately severe depression were significantly higher than in patients with minimal depression (198 µg/g vs. 66,9 µg/g, p = 0.04). Calprotectin level was corelated with the following depressive symptoms: autolytic ideation (ρ = 0.557, p = 0.001), fatigue (ρ = 0.514, p = 0.002), slow movement (ρ = 0.490, p = 0.003), and sleep disorders (ρ = 0.403, p = 0.014). Calprotectin was an independent predictor of depression with an odds ratio of 1.01 (95%: 1.002–1.03, p < 0.01). An ROC analysis showed that a level of calprotectin of 131 µg/g or higher has a sensitivity of 82%, a specificity of 61%, and an accuracy of 70% for predicting depression. In this study, no significant correlations were found between calprotectin level and anxiety. Conclusions: Calprotectin levels are associated with the severity of depression, and checking for a calprotectin level of 131 µg/g or higher may be a potential accessible screening test for depression in patients with inflammatory bowel disease.

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Elevated serum calprotectin as an inflammatory marker in obstructive sleep apnea

Kum

Çandar

et al. 2020

CRANIO®

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The importance of calprotectin levels in obstructive sleep apnea syndrome severity

Abstract: Calprotectin values were elevated in OSAS patients and it can be used as a marker of severe OSAS. Future studies can support our study.

Cited by 3 publications

References 31 publications

Calprotectin in Lung Diseases

Calprotectin in Lung Diseases

Calprotectin, Biomarker of Depression in Patients with Inflammatory Bowel Disease?

Elevated serum calprotectin as an inflammatory marker in obstructive sleep apnea

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