The Importance of Cardiac Biomarkers on Remodelling After Myocardial Infarction

Abstract

BackgroundThe purpose of this study is to evaluate the importance of tenascin-C ( TNC), N-terminal pro brain natriuretic peptide (NT-proBNP) and C-reactive protein (CRP) on LV remodelling after myocardial infarction (MI).MethodsFifty-seven stable patients with subacute anterior MI who had total or subtotal occlusion in the infarct-related left anterior desending artery in coronary angiography were enrolled the study. 18 of patients who had total occlusion received only medical theraphy, 19 of patients who had total occlusion received successful PCI+ medical theraphy and 20 of patients who had subtotal occlusion received successful PCI+ medical theraphy. Left ventricular volumes and ejection fractions (EF) were measured with echocardiography. Serum TNC, NT-proBNP and CRP levels were measured at admission and a month after treatment.ResultsThere was significant increase in LV end-diastolic volume (LVEDV) and LV end-systolic volume (LVESV) baseline to follow-up in total-PCI group. Baseline to follow-up; a borderline significant increase was observed in LVEDV in the total-medical group. No significant difference was seen in LV volumes and EF in the subtotal-PCI group. NT-proBNP, TNC and CRP levels were decreased in all groups. The decrease in NT-proBNP and CRP values were significant in the total-medical and subtotal-PCI group but in the total-PCI group they were not significant. The decrease of TNC was significant in all groups but the lowest decrease was seen in the total-PCI group.ConclusionTNC, NT-proBNP and CRP reflect LV remodelling in accordance with echocardiography after MI.KeywordsTenascin-C; NT-pro BNP; CRP; Remodelling; Myocardial infarction

Value of serum tenascin-C in patients with acute myocardial infarction

“…TN-C levels in the sera of patients with AMI (Group I) and patients with congestive heart failure on top of acute myocardial infarction (Group II) were significantly higher than those of healthy volunteers. In agreement with our study, Celik et al 17 have stated that TN-C levels were high in patients with myocardial infarction and successful revascularization treatment of patients was associated with decrease in TN-C levels. In the same year, Sato et al 18 noted significantly elevated TN-C levels within 24 h after onset.…”

Biomarker for the Prediction of Major Adverse Cardiac Events in Patients with Non-ST-Segment Elevation Myocardial Infarction

“…When MACE were MI of Figure 2 and Re-PCI of Figure 3 , the AUC was statistically nonsignificant. Figures 4 and 5 show the AUC when MACE was cardiac death and CABG [ 24 ].…”

Time Course of the Effects of Buxin Yishen Decoction in Promoting Heart Function and Inhibiting the Progression of Renal Fibrosis in Myocardial Infarction Caused Type 2 Cardiorenal Syndrome Rats

“…BNP is secreted mainly by the ventricles and is a sensitive and specific indicator of ventricular dysfunction, which has become an important biomarker of cardiac function in CHF patients (Celik et al, 2012; Feldman et al, 2013). It has been widely recognized that RASS and AngII play critical roles in the development of renal fibrosis (Ruster and Wolf, 2011; Chang et al, 2016) and in which CTGF is the key factor (Gu et al, 2012; Montford and Furgeson, 2017).…”