The importance of circulating tumor products as „liquid biopsies” in colorectal cancer

Miscoci, Alina; Pirvu, C; Calborean, Veronica; Streba, Costin Teodor; Rogoveanu, Otilia Constantina; Pădureanu, Vlad; Vere, Cristin Constantin

doi:10.22543/7674.51.p3945

Cited by 4 publications

(2 citation statements)

References 32 publications

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“…The right ventricle, due to its structural features (asymmetric geometry, thin wall), adapts well to preload (volume) and with difficulty to overload and pulmonary hypertension. VD will reshape as structure (hypertrophy, dilation) and function (RV hypertrophy is associated with alteration of myocyte microtubules, changes in calcium uptake, decreased sarcomer contraction) [26]. In addition, hyperventilation syndrome which is present in pulmonary diseases with hypoxia, hypercapnia, acidosis and increased blood viscosity, secondary increased erythrocyte count, accentuates RV suffering [27][28][29].…”

Section: Resultsmentioning

confidence: 99%

Early Predictive Biochemical, Electrocardiographic and Echocardiographic Markers for Cardiac Damage in Patients with Pulmonic Silicosis

Dinescu¹,

Puiu²,

Dinescu³

et al. 2019

Rev. Chim.

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The aim of this study was to identify correlations between electrocardiographic and echocardiographic changes in patients with silicosis prior to the occurrence of chronic pulmonary heart disease. We conducted a prospective, descriptive, analytical study, in which we included a group of 67 patients consecutively admitted to the Health Promotion and Occupational Medicine Clinic between December 2016 and January 2018, aged 47 to 78 years.There was a biochemical and electrocardiographic evaluation for each patient as well as a right ventricle echocardiographic evaluation (diameters, volumes, function). A control group, including 25 patients with benign minor diseases that required a cardiologist consultation, was also used. From the electrocardiographic point of view, slight changes were observed regarding the waves of electrical activity of the right ventricle. Taking into account the degree of ventilatory dysfunction (depending on FEV1), changes in right heart echocardiographic parameters were identified. Thus, in what the most important right ventricular parameters, including the tricuspid annular plane systolic excursion (TAPSE) or the RV index of myocardial performance (RVMPI) were concerned, values at the upper limit of normality were recorded in most patients with moderate and severe ventilatory dysfunction. Values of echocardiographic parameters of the right heart at the upper limit of normality, correlated with the degree of ventilatory dysfunction, are early markers for cardiovascular damage in patients with pulmonary silicosis prior to the occurrence of chronic pulmonary heart disease also known ascor pulmonale.

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Section: Resultsmentioning

confidence: 99%

Early Predictive Biochemical, Electrocardiographic and Echocardiographic Markers for Cardiac Damage in Patients with Pulmonic Silicosis

Dinescu¹,

Puiu²,

Dinescu³

et al. 2019

Rev. Chim.

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“…High phytoestrogens intake interferes with estrogenic metabolism causing changes in the colonic mucosa such as increasing in ER-α expression, decreasing apoptosis and inducing inflammation (13).…”

Section: Discussionmentioning

confidence: 99%

Occlusive stenosis - atypical presentation of right colon cancer

Banu¹,

Constantin²,

Păunica³

et al. 2018

J Clin Invest Surg.

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Colorectal cancers are one of the most frequent malignancies worldwide. Significant differences are described in relation to the location of tumors within the colon. Thus, between right and left colon cancer there are epidemiological, clinical, genetic, evolutionary and prognostic differences.Considering these premises, right and left colon cancers can be seen as distinct pathological entities. In right colon cancer the initial phases are often asymptomatic and the presence of symptoms is in relation to advanced phases and complications.We report the case of a 64-year-old man with no significant medical history who was admitted and operated as an emergency for stenotic and perforated tumor of the right colon. Operative exploration revealed distended small bowel loops and caecum up to the ascending colon where a stenosing tumor is found. The tumor extends to a small bowel loop and also exhibit a perforation.Right hemicolectomy was performed, with favorable postoperative evolution and discharge on 7th day.

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Melanoma and autoimmunity: spontaneous regressions as a possible model for new therapeutic approaches

Motofei

2019

Melanoma Research

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Until now, malignancy has been considered a cellular problem represented by the perturbed (uncontrolled) division of the cells associated with invasion and metastasis. Contrary to this classical approach, a new perspective suggests that cancerous disease is, in fact, a supracellular problem represented by inadequate evolution of complex supracellular processes (embryogenesis, development, regeneration, etc.). Such complex processes would be disconnected from the real needs of the body, inducing unnecessary or even dangerous events such as an exacerbated rate of the cell division, angiogenesis, immunosuppression (specific to embryogenesis and melanoma), invasion (mediated by trophoblastic/placental factors in melanoma), and migration (specific to neural crest cells, which generate melanocytes – the most common origin for melanoma). As a result, a correct and comprehensive interpretation of cancer (causes, evolution, therapy, and prevention) should be conducted from a supracellular perspective. After presenting the supracellular perspective, this article further investigates the favorable evolution of malignant melanoma in two distinct situations: in patients receiving no therapy and in patients treated with immune-checkpoint inhibitors. In patients receiving no therapy, spontaneous regressions of melanoma could be the result of several autoimmune reactions (inducing not only melanoma regression but also vitiligo, an autoimmune event frequently associated with melanoma). Patients treated with immune-checkpoint inhibitors develop similar autoimmune reactions, which are clearly correlated with better therapeutic results. The best example is vitiligo, which is considered a positive prognostic factor for patients receiving immune-checkpoint inhibitors. This finding indicates that immune-checkpoint inhibitors induce distinct types of autoimmune events, some corresponding to specific favorable autoimmune mechanisms (favoring tumor regression) and others to common unfavorable adverse reactions (which should be avoided or minimized). In conclusion, the spectrum of autoimmune reactions induced by immune-checkpoint inhibitors should be restricted in the near future to only these specific favorable autoimmune mechanisms. In this way, the unnecessary autoimmune reactions/autoaggressions could be avoided (a better quality of life), and treatment specificity and efficiency should increase (a higher response rate for melanoma therapy).

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The importance of circulating tumor products as „liquid biopsies” in colorectal cancer

Cited by 4 publications

References 32 publications

Early Predictive Biochemical, Electrocardiographic and Echocardiographic Markers for Cardiac Damage in Patients with Pulmonic Silicosis

Early Predictive Biochemical, Electrocardiographic and Echocardiographic Markers for Cardiac Damage in Patients with Pulmonic Silicosis

Occlusive stenosis - atypical presentation of right colon cancer

Melanoma and autoimmunity: spontaneous regressions as a possible model for new therapeutic approaches

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