The importance of colonoscopy bowel preparation for the detection of colorectal lesions and colorectal cancer prevention

Burke, Carol A.; Johnson, David A.; Cash, Brooks D.

doi:10.1055/a-1127-3144

Cited by 46 publications

(41 citation statements)

References 106 publications

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“…Symptomatic or asymptomatic individuals considered at high risk are invited for screening (Christopher et al, 2019). Prior to the procedure, individuals are asked to follow a diet, ingest laxatives and 2 L of solution the night before the procedure to prepare the colon and have a clean environment for the inspection (Sharma et al, 2020). This process is not well accepted (Kelly et al, 2012) and a poor preparation is related to an incomplete colonoscopy (Shah et al, 2007;Brahmania et al, 2012).…”

Section: Medical Proceduresmentioning

confidence: 99%

Endorobots for Colonoscopy: Design Challenges and Available Technologies

Manfredi

2021

Front. Robot. AI

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Colorectal cancer (CRC) is the second most common cause of cancer death worldwide, after lung cancer (Sung et al., 2021). Early stage detection is key to increase the survival rate. Colonoscopy remains to be the gold standard procedure due to its dual capability to optically inspect the entire colonic mucosa and to perform interventional procedures at the same time. However, this causes pain and discomfort, whereby it requires sedation or anaesthesia of the patient. It is a difficult procedure to perform that can cause damage to the colonic wall in some cases. Development of new technologies aims to overcome the current limitations on colonoscopy by using advancements in endorobotics research. The design of these advanced medical devices is challenging because of the limited space of the lumen, the contorted shape, and the long tract of the large bowel. The force applied to the colonic wall needs to be controlled to avoid collateral effects such as injuries to the colonic mucosa and pain during the procedure. This article discusses the current challenges in the colonoscopy procedure, the available locomotion technologies for endorobots used in colonoscopy at a prototype level and the commercial products available.

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Section: Medical Proceduresmentioning

confidence: 99%

Endorobots for Colonoscopy: Design Challenges and Available Technologies

Manfredi

2021

Front. Robot. AI

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“…Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the United States. Over the past three decades, the rates of colon cancer and colon cancer-related mortality have decreased due to the introduction of colonoscopy and polypectomy of adenomatous polyps[ 40 , 41 ]. A large cohort study conducted in the United States has also demonstrated an approximately 70% reduction in deaths after the institution of colonoscopy[ 42 ].…”

Section: Ai and Endoscopymentioning

confidence: 99%

Evolving role of artificial intelligence in gastrointestinal endoscopy

Parasher¹,

Wong²,

Rawat³

2020

WJG

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Artificial intelligence (AI) is a combination of different technologies that enable machines to sense, comprehend, and learn with human-like levels of intelligence. AI technology will eventually enhance human capability, provide machines genuine autonomy, and reduce errors, and increase productivity and efficiency. AI seems promising, and the field is full of invention, novel applications; however, the limitation of machine learning suggests a cautious optimism as the right strategy. AI is also becoming incorporated into medicine to improve patient care by speeding up processes and achieving greater accuracy for optimal patient care. AI using deep learning technology has been used to identify, differentiate catalog images in several medical fields including gastrointestinal endoscopy. The gastrointestinal endoscopy field involves endoscopic diagnoses and prognostication of various digestive diseases using image analysis with the help of various gastrointestinal endoscopic device systems. AI-based endoscopic systems can reliably detect and provide crucial information on gastrointestinal pathology based on their training and validation. These systems can make gastroenterology practice easier, faster, more reliable, and reduce inter-observer variability in the coming years. However, the thought that these systems will replace human decision making replace gastrointestinal endoscopists does not seem plausible in the near future. In this review, we discuss AI and associated various technological terminologies, evolving role in gastrointestinal endoscopy, and future possibilities.

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“…While the majority of healthy patients undergo colonoscopy safely and effectively after the use of any commercial bowel preparation, certain patients, including those with chronic diseases such as renal disease or diabetes, require special consideration. 19 , 20 A low-volume bowel preparation that is safe and effective in high-risk populations, such as those with renal impairment or diabetes, would be welcomed.…”

Section: Introductionmentioning

confidence: 99%

Safety and efficacy of sodium picosulfate, magnesium oxide, and citric acid bowel preparation in patients with baseline renal impairment or diabetes: subanalysis of a randomized, controlled trial

Mankaney

Ando

Dahdal

et al. 2021

Therap Adv Gastroenterol

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Background: Selecting a bowel preparation for patients with renal impairment or diabetes requires special consideration. We aimed to describe the effect of baseline renal impairment or diabetes on the safety, efficacy, and tolerability of low-volume sodium picosulfate, magnesium oxide, and citric acid (SPMC) ready-to-drink oral solution bowel preparation. Methods: A post hoc secondary analysis was performed from a randomized, assessor-blinded study of SPMC oral solution bowel preparation in participants with mild or moderate baseline renal impairment or diabetes. Primary efficacy endpoint (‘responders’) was the proportion of participants with ‘excellent’ or ‘good’ ratings on a modified Aronchick Scale (AS). Secondary efficacy outcomes were the quality of ascending colon cleansing from the Boston Bowel Preparation Scale (BBPS), and selected results from the Mayo Clinic Bowel Prep Tolerability Questionnaire. Safety assessments included adverse events (AEs), adenoma detection, and laboratory evaluations. Results: Similar overall colon cleansing was demonstrated in the subgroups, with >85% of participants in any subgroup rated as responders by the AS, and >92% of participant responders by the BBPS. Most participants reported a tolerable bowel preparation, regardless of baseline renal impairment or diabetes history. Safety of SPMC oral solution was similar between all subgroups and the overall cohort. For the mild renal impairment, moderate renal impairment, and diabetes subgroups, respectively, commonly reported, drug-related AEs were nausea (2.6%, 5.3%, 1.4%) and headache (2.2%, 2.6%, 4.3%). Conclusions: Ready-to-drink SPMC oral solution demonstrated efficacious colon cleansing in patients with baseline mild/moderate renal impairment or diabetes, with a tolerable bowel preparation reported by most. Clinical Trial Registration: ClinicalTrials.gov identifier: NCT03017235

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The importance of colonoscopy bowel preparation for the detection of colorectal lesions and colorectal cancer prevention

Cited by 46 publications

References 106 publications

Endorobots for Colonoscopy: Design Challenges and Available Technologies

Endorobots for Colonoscopy: Design Challenges and Available Technologies

Evolving role of artificial intelligence in gastrointestinal endoscopy

Safety and efficacy of sodium picosulfate, magnesium oxide, and citric acid bowel preparation in patients with baseline renal impairment or diabetes: subanalysis of a randomized, controlled trial

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