The importance of interstitial cells of cajal in the gastrointestinal tract

Al‐Shboul, Othman

doi:10.4103/1319-3767.105909

Cited by 112 publications

(106 citation statements)

References 123 publications

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“…In the muscular layer, cells are subdivided into sub-and intramuscular ICC. Intramuscular ICC present either in the longitudinally, circularly oriented SMF layer or in the deep muscular plexus [Al-Shboul, 2013]. In the current study, different types of telopodes of various thicknesses were detected: thin and thick telopodes.…”

Section: Discussionmentioning

confidence: 84%

New Description of Telocyte Sheaths in the Bovine Uterine Tube: An Immunohistochemical and Scanning Microscopic Study

Abd‐Elhafeez

Soliman

2016

Cells Tissues Organs

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Telocytes are a special type of interstitial cells characterized by distinctive cellular extensions with alternating thin segments (podomers) and dilations (podoms). Telocytes establish contact with various cells and structures, but their role in the regulation of the function of many cell types is still obscure. The aim of the current study was to investigate the morphology, histochemistry, and immunohistochemistry of telocytes, and their distribution, organization, and morphometric measurements in different layers of the adult bovine uterine tube. Telocytes showed positive immunostaining for CD117, S-100 protein, vimentin, desmin, α-smooth muscle actin, tubulin, laminin, estrogen receptor-α, and progesterone receptor. They were organized in different types of sheaths: subepithelial, inner/outer perimuscular, and intramuscular sheaths. Telocytes were scattered in the lamina propria, in the muscular layer, and the serosa. According to their size, they were grouped into different types of telocytes: small, large, and giant telocytes. Small telocytes were the most common type and located in all layers; large telocytes were observed in the epithelium, lamina propria, and inner/outer perimuscular and intramuscular sheaths, and giant telocytes were found in the external layer of the outer perimuscular sheath. Telocytes were connected by thin and thick telopodes (fenestrated membranes). Fenestrated membranes enabled connections between telocytes along the entire muscular wall of the uterine tube. Telocytes established an extensive biological network of different types of cells and structures, including epithelial, muscular, and mast cells, blood vessels, glomus, and nerve fibers. We hypothesize that telocytes help to organize the functional coordination between different types of cells in the uterine tube.

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Section: Discussionmentioning

confidence: 84%

New Description of Telocyte Sheaths in the Bovine Uterine Tube: An Immunohistochemical and Scanning Microscopic Study

Abd‐Elhafeez

Soliman

2016

Cells Tissues Organs

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“…They coordinate the pacemaker activity and propagation of slow waves, and act in the sensitive identification of muscle stretch phenomena. In the gastrointestinal tract, they are distributed from the upper esophageal sphincter to the internal anal sphincter,13 juxtaposed to the nerve endings of myenteric motor neurons. The presence of the tyrosine kinase receptor on the cell membrane allowed the development of anti-c-kit antibodies for the histological identification of these cells 14.…”

Section: Discussionmentioning

confidence: 99%

Hirschsprung's disease – Postsurgical intestinal dysmotility

Romaneli

Ribeiro

Bustorff‐Silva

et al. 2016

Revista Paulista de Pediatria (English Edition)

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Objective:To describe the case of an infant with Hirschsprung's disease presenting as total colonic aganglionosis, which, after surgical resection of the aganglionic segment persisted with irreversible functional intestinal obstruction; discuss the difficulties in managing this form of congenital aganglionosis and discuss a plausible pathogenetic mechanism for this case.Case description:The diagnosis of Hirschsprung's disease presenting as total colonic aganglionosis was established in a two-month-old infant, after an episode of enterocolitis, hypovolemic shock and severe malnutrition. After colonic resection, the patient did not recover intestinal motor function that would allow enteral feeding. Postoperative examination of remnant ileum showed the presence of ganglionic plexus and a reduced number of interstitial cells of Cajal in the proximal bowel segments. At 12 months, the patient remains dependent on total parenteral nutrition.Comments:Hirschsprung's disease presenting as total colonic aganglionosis has clinical and surgical characteristics that differentiate it from the classic forms, complicating the diagnosis and the clinical and surgical management. The postoperative course may be associated with permanent morbidity due to intestinal dysmotility. The numerical reduction or alteration of neural connections in the interstitial cells of Cajal may represent a possible physiopathological basis for the condition.

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“…Collagen and elastin are the main components determining the passive biomechanical properties of the esophagus . Furthermore, the submucosa layer contains Auerbach's plexus, and the muscle layer contains Meissner's plexus and the interstitial cells of Cajal (ICCs) . The sensorimotor function of the esophagus relies on the normal structure of muscle cells, ICCs, and the nerve plexus in the esophageal wall.…”

Section: Normal Esophageal Anatomy Function and Biomechanical Propementioning

confidence: 99%

Diabetes‐induced mechanophysiological changes in the esophagus

Zhao

Gregersen

2016

Annals of the New York Academy of Sciences

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Esophageal disorders are common in diabetes mellitus (DM) patients. DM induces mechanostructural remodeling in the esophagus of humans and animal models. The remodeling is related to esophageal sensorimotor abnormalities and to symptoms frequently encountered by DM patients. For example, gastroesophageal reflux disease (GERD) is a common disorder associated with DM. This review addresses diabetic remodeling of esophageal properties and function in light of the Esophagiome, a scientifically based modeling effort to describe the physiological dynamics of the normal, intact esophagus built upon interdisciplinary approaches with applications for esophageal disease. Unraveling the structural, biomechanical, and sensory remodeling of the esophagus in DM must be based on a multidisciplinary approach that can bridge the knowledge from a variety of scientific disciplines. The first focus of this review is DM-induced morphodynamic and biomechanical remodeling in the esophagus. Second, we review the sensorimotor dysfunction in DM and how it relates to esophageal remodeling. Finally, we discuss the clinical consequences of DM-induced esophageal remodeling, especially in relation to GERD. The ultimate aim is to increase the understanding of DM-induced remodeling of esophageal structure and sensorimotor function in order to assist clinicians to better understand the esophageal disorders induced by DM and to develop better treatments for those patients.

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The importance of interstitial cells of cajal in the gastrointestinal tract

Cited by 112 publications

References 123 publications

New Description of Telocyte Sheaths in the Bovine Uterine Tube: An Immunohistochemical and Scanning Microscopic Study

New Description of Telocyte Sheaths in the Bovine Uterine Tube: An Immunohistochemical and Scanning Microscopic Study

Hirschsprung's disease – Postsurgical intestinal dysmotility

Diabetes‐induced mechanophysiological changes in the esophagus

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