The importance of intracellular bacterial biofilm in infectious diseases

Mirzaei, Rasoul; Mohammadzadeh, Rokhsareh; Sholeh, Mohammad; Karampoor, Sajad; Abdi, Milad; Dogan, Eyup; Moghadam, Mohammad Shokri; Kazemi, Sima; Jalalifar, Saba; Dalir, Amine; Yousefimashouf, Rasoul; Mirzaei, Ebrahim; Khodavirdipour, Amir; Alikhani, Mohammad Yousef

doi:10.1016/j.micpath.2020.104393

Cited by 36 publications

(22 citation statements)

References 98 publications

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“…Recently, it has been postulated that such aggregates/BLS may be the forerunners of typical surface‐attached biofilms (Kragh et al., 2016). Additionally, BLS/aggregates formed by E. coli , P. aeruginosa , and other bacteria have been found within human cells, providing another means of bacterial evasion of antibiotic therapy (Mirzaei et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

Malonate utilization by Pseudomonas aeruginosa affects quorum‐sensing and virulence and leads to formation of mineralized biofilm‐like structures

Elmassry

Bisht

Colmer-Hamood

et al. 2021

Molecular Microbiology

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Pseudomonas aeruginosa is a ubiquitous Gram-negative opportunistic pathogen that survives in a wide range of environments (Botzenhart & Döring, 1993). P. aeruginosa causes serious infections in immunocompromised patients, including bacteremia in burn and trauma patients, urinary tract infections in hospitalized patients, and respiratory infections in cystic fibrosis patients (Bodey et al., 1983). These infections are difficult to eradicate due to the ability of P. aeruginosa to form persistent biofilms as well as its resistance to commonly used antibiotics (Costerton et al., 1999). The World Health Organization listed P. aeruginosa as a major bacterial

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Section: Introductionmentioning

confidence: 99%

Malonate utilization by Pseudomonas aeruginosa affects quorum‐sensing and virulence and leads to formation of mineralized biofilm‐like structures

Elmassry

Bisht

Colmer-Hamood

et al. 2021

Molecular Microbiology

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“…Bacterial biofilm, which is a cluster of cells that attach to biotic or abiotic surfaces (Mirzaei et al, 2020 ), could be another factor involved in NDs and psoriasis pathogenesis. Apparently, there is such biofilm in the brain of patients with AD, which is located in the early pathological plaques of brain samples in an extracellular state (Mirzaei et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Psoriasis and neurodegenerative diseases—a review

Nowowiejska

Baran

Flisiak

2022

Front. Mol. Neurosci.

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Psoriasis is a chronic skin disease with underlying genetic, inflammatory and immunological background, which is a great medical problem, currently regarded as a systemic condition. Neurodegenerative diseases (NDs) are characterized by a progressive loss of nervous tissue, which affects elderly people more frequently; therefore, it is suspected that, due to society's aging, morbidity is going to increase. We performed a thorough review in order to investigate for the first time whether psoriasis may predispose to different particular neurodegenerative diseases—Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). PubMed search resulted in the retrieval of 833 records, of which 77 eligible were included in the review. Our thorough analysis revealed there are some potential links between psoriasis and NDs (inflammation, oxidative stress, genetics, cardiometabolic disorders), but there is no strong evidence that psoriasis may predispose to NDs. Based on the evidence, it seems that the risk of PD in psoriatics is not increased, and the evidence for increased risk of AD slightly prevails the data that state the opposite. ALS risk does not seem to be increased in psoriatics. The paucity of original studies does not allow for the formulation of definitive conclusions but encourages to perform further investigations.

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“…At present, the infection rate of group B streptococcus among perinatal pregnant women and newborns in China is very high [23], so the prevention and detection of group B streptococcus should be carried out [24]. The drug resistance mechanism of Group B streptococcus to erythromycin mainly has two aspects [25]. The rst is that Group B streptococcus can rely on energy e ux pumps.…”

Section: Discussionmentioning

confidence: 99%

Infection and drug resistance of Streptococcus agalactiae among perinatal pregnant women in Xinjiang

Guo

Luo

Jia

et al. 2021

Preprint

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Background: Group B streptococcus (Streptococcus agalactiae) is one of the most common pathogens causing meningitis, bacteremia and pneumonia. The drug resistance mechanisms of group B streptococcus in different countries and regions also show regional differences.Method: The study population was comprised of 1877 pregnant women of 34-38 weeks who underwent prenatal examination in the gynecology and obstetrics outpatient clinic of Xinjiang People's Hospital, between January 1, 2019 and January 31, 2020. Clinic specimens were collected and identified by the API bacteria Rapid Identification card for the downstream group B Streptococcus (Streptococcus agalactiae) isolation. Drug susceptibility of the Streptococcus agalactiae isolated was detected by Kirby-Bauer disk diffusion method. Macrolide–lincosamide–streptogramin B (MLSB) resistance was determined by D test. Real-time quantitative polymerase chain reaction and Gene sequencing was performed for the resistance genes ermA, ermB, mreA, erm (47), mefA/E and Lin B.Results: 149 Streptococcus agalactiae-positive strains were identified by clinical isolation, with a positive rate of 7.94%. Group B Streptococcus showed 100% susceptibility to linezolid, penicillin, vancomycin, meropenem, ampicillin, ceftriaxone, 44.97%, 35.57%, 56.38% and 29.53% susceptibility to levofloxacin, erythromycin, tetracycline and clindamycin, respectively. Among the 149 isolates, 127 strains showed macrolide resistance phenotype. The detection rate of intrinsic resistance phenotype (cMLS) was 40.94% (59/127), active efflux resistance phenotype (MS) 9.45% (12/127), and induced resistance phenotype (iMLS) 22.83% (29/127).Conclusion: The ermB gene-mediated 50s ribosome target site change co-existing with mreA gene for macrolide resistance efflux may play a major role in the mechanism of Streptococcus agalactiae resistance macrolide resistance of in perinatal women in Xinjiang. The change of 50s ribosomal target site mediated by ermB gene may be the main reason for drug cross-resistance.

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The importance of intracellular bacterial biofilm in infectious diseases

Cited by 36 publications

References 98 publications

Malonate utilization by Pseudomonas aeruginosa affects quorum‐sensing and virulence and leads to formation of mineralized biofilm‐like structures

Malonate utilization by Pseudomonas aeruginosa affects quorum‐sensing and virulence and leads to formation of mineralized biofilm‐like structures

Psoriasis and neurodegenerative diseases—a review

Infection and drug resistance of Streptococcus agalactiae among perinatal pregnant women in Xinjiang

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