The Importance of Lipidomic Approach for Mapping and Exploring the Molecular Networks Underlying Physical Exercise: A Systematic Review

Latino, Francesca; Cataldi, Stefania; Carvutto, Roberto; Candia, Michele De; D’Elia, Francesca; Patti, Antonino; Bonavolontà, Valerio; Fischetti, Francesco

doi:10.3390/ijms22168734

Cited by 11 publications

(8 citation statements)

References 104 publications

(140 reference statements)

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“…Physical exercise has numerous repercussions on metabolism and function of different organs and tissues by enhancing whole-body metabolic homeostasis in response to different exercise-related adaptations. In a review, Latino et al showed as exercise determine significant changes in lipidomic profiles, but they manifested in very different ways depending on the type of tissue examined ( 52 ) As healthy lifestyle during pubertal years is highly related to accelerated biological maturation in childhood and adolescence ( 53 , 54 ), its recommended to consider it in future studies.…”

Section: Discussionmentioning

confidence: 99%

Is early or late biological maturation trigger obesity? A machine learning modeling research in Turkey boys and girls

et al. 2023

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Biological maturation status can affect individual differences, sex, height, body fat, and body weight in adolescents and thus may be associated with obesity. The primary aim of this study was to examine the relationship between biological maturation and obesity. Overall, 1,328 adolescents (792 boys and 536 girls) aged 12.00 ± 0.94–12.21 ± 0.99 years, respectively (measured for body mass, body stature, sitting stature). Body weights were deter-mined with Tanita body analysis system and adolescent obesity status was calculated according to the WHO classification. Biological maturation was determined according to the somatic maturation method. Our results showed that boys mature 3.077-fold later than girls. Obesity was an increasing effect on early maturation. It was determined that being obese, overweight and healthy-weight increased the risk of early maturation 9.80, 6.99 and 1.81-fold, respectively. The equation of the model predicting maturation is: Logit (P) = 1/(1 + exp. (− (−31.386 + sex-boy * (1.124) + [chronological age = 10] * (−7.031) + [chronological age = 11] * (−4.338) + [chronological age = 12] * (−1.677) + age * (−2.075) + weight * 0.093 + height * (−0.141) + obesity * (−2.282) + overweight * (−1.944) + healthy weight * (−0.592)))). Logistic regression model predicted maturity with 80.7% [95% CI: 77.2–84.1%] accuracy. In addition, the model had a high sensitivity value (81.7% [76.2–86.6%]), which indicates that the model can successfully distinguish adolescents with early maturation. In conclusion, sex and obesity are independent predictors of maturity, and the risk of early maturation is increased, especially in the case of obesity and in girls.

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Section: Discussionmentioning

confidence: 99%

Is early or late biological maturation trigger obesity? A machine learning modeling research in Turkey boys and girls

et al. 2023

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“…Scoring was performed independently by the four aforementioned investigators. The modified Jadad score ranges from 0 to 5, and each question has a dichotomous answer (yes: 1 point; no: 0 points) [30,31]. A higher score indicates better RCT quality.…”

Section: Quality Assessmentmentioning

confidence: 99%

Safety and Efficacy of Ultrasound-Guided Perineural Hydrodissection as a Minimally Invasive Treatment in Carpal Tunnel Syndrome: A Systematic Review

Sveva,

Farì,

Fai

et al. 2024

JPM

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Ultrasound-guided perineural hydrodissection (HD) is a novel technique that has been found to be effective in providing mechanical release of perineural adhesions and decompression of the nerve, reducing inflammation and edema and restoring its physiological function. It has a significant impact on chronic neuropathic pain (20 ± 4 weeks with VAS < 5 or VAS diminished by 2 points after the procedure). Carpal tunnel syndrome (CTS) is a common entrapment mononeuropathy, and its distribution is typically innervated by the median nerve. Patients with mild or moderate CTS may benefit from nonsurgical treatments or conservative therapies. This review was conducted following the preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement guidelines. Four investigators assessed each title, abstract, and full-text article for eligibility, with disagreements being resolved by consensus with two experienced investigators. The qualitative assessment of the studies was carried out using the modified Oxford quality scoring system, also known as the modified Jadad score. Furthermore, risk of possible biases was assessed using the Cochrane collaboration tool. The results of this review suggest that US-guided HD is an innovative, effective, well-tolerated, and safe technique (11 out of 923 patients had collateral or side effects after the procedure). However, further studies comparing all drugs and with a larger sample population are required to determine the most effective substance.

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“…The applied methodological approaches of modern‐age lipidomics help differentiate between lipid classes and, in some cases, are specific enough to identify lipid chain structures including double bonding and side chain locations which may be important to classify the source of the lipid or the biological process in which it was synthesized. This allows researchers to study the flux of complex biological systems more appropriately to further understand the metabolic impact of exercise across varied populations 102 . Lipidomics remains an emerging method within SES research but, nonetheless, is providing data to improve the general understanding of lipid metabolism in exercise‐based scenarios.…”

Section: Analytical Approaches For Ms‐based Investigations In Ses In ...mentioning

confidence: 99%

“…This allows researchers to study the flux of complex biological systems more appropriately to further understand the metabolic impact of exercise across varied populations. 102 Lipidomics remains an emerging method within SES research but, nonetheless, is providing data to improve the general understanding of lipid metabolism in exercise‐based scenarios.…”

Section: Analytical Approaches For Ms‐based Investigations In Ses In ...mentioning

confidence: 99%

Mass Sportrometry: An annual look back at applications of mass spectrometry in sport and exercise science

Ong

Green

Rowland

et al. 2023

Analytical Science Advances

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Research in sport and exercise science (SES) is reliant on robust analyses of biomarker measurements to assist with the interpretation of physiological outcomes. Mass spectrometry (MS) is an analytical approach capable of highly sensitive, specific, precise, and accurate analyses of a range of biomolecules, many of which are of interest in SES including, but not limited to, endogenous metabolites, exogenously administered compounds (e.g. supplements), mineral ions, and circulating/tissue proteins. This annual review provides a summary of the applications of MS across studies investigating aspects related to sport or exercise in manuscripts published, or currently in press, in 2022. In total, 93 publications are included and categorized according to their methodologies including targeted analyses, metabolomics, lipidomics, proteomics, and isotope ratio/elemental MS. The advantageous analytical opportunities afforded by MS technologies are discussed across a selection of relevant articles. In addition, considerations for the future of MS in SES, including the need to improve the reporting of assay characteristics and validation data, are discussed, alongside the recommendation for selected current methods to be superseded by MS‐based approaches where appropriate. The review identifies that a targeted, mostly quantitative, approach is the most commonly applied MS approach within SES, although there has also been a keen interest in the use of ‘omics’ to perform hypothesis‐generating research studies. Nonetheless, MS is not commonplace in SES at this time, but its use to expand, and possibly improve, the analytical options should be continually considered to exploit the benefits of analytical chemistry in exercise/sports‐based research. Overall, it is exciting to see the gradually increasing adoption of MS in SES and it is expected that the number, and quality, of MS‐based assays in SES will increase over time, with the potential for 2023 to further establish this technique within the field.

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The Importance of Lipidomic Approach for Mapping and Exploring the Molecular Networks Underlying Physical Exercise: A Systematic Review

Cited by 11 publications

References 104 publications

Is early or late biological maturation trigger obesity? A machine learning modeling research in Turkey boys and girls

Is early or late biological maturation trigger obesity? A machine learning modeling research in Turkey boys and girls

Safety and Efficacy of Ultrasound-Guided Perineural Hydrodissection as a Minimally Invasive Treatment in Carpal Tunnel Syndrome: A Systematic Review

Mass Sportrometry: An annual look back at applications of mass spectrometry in sport and exercise science

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