The Importance of Microbiota and Fecal Microbiota Transplantation in Pancreatic Disorders

Boicean, Adrian; Ichim, Cristian; Todor, Samuel Bogdan; Anderco, Paula; Popa, Mirela Livia

doi:10.3390/diagnostics14090861

Cited by 15 publications

(3 citation statements)

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“…Since macrophage polarization is a highly dynamic and finely tuned process, further research is needed to fully elucidate the detailed mechanisms underlying this phenomenon. Recent studies have highlighted the role of microbiota in regulating the tissue microenvironment of the pancreas [ 107 , 108 , 109 ]. Understanding the detailed mechanisms of microbiota-mediated cellular crosstalk in the pancreas is a significant challenge in overcoming pancreatic diseases.…”

Section: Discussionmentioning

confidence: 99%

The Pivotal Role of Macrophages in the Pathogenesis of Pancreatic Diseases

Ryu,

Lee

2024

IJMS

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The pancreas is an organ with both exocrine and endocrine functions, comprising a highly organized and complex tissue microenvironment composed of diverse cellular and non-cellular components. The impairment of microenvironmental homeostasis, mediated by the dysregulation of cell-to-cell crosstalk, can lead to pancreatic diseases such as pancreatitis, diabetes, and pancreatic cancer. Macrophages, key immune effector cells, can dynamically modulate their polarization status between pro-inflammatory (M1) and anti-inflammatory (M2) modes, critically influencing the homeostasis of the pancreatic microenvironment and thus playing a pivotal role in the pathogenesis of the pancreatic disease. This review aims to summarize current findings and provide detailed mechanistic insights into how alterations mediated by macrophage polarization contribute to the pathogenesis of pancreatic disorders. By analyzing current research comprehensively, this article endeavors to deepen our mechanistic understanding of regulatory molecules that affect macrophage polarity and the intricate crosstalk that regulates pancreatic function within the microenvironment, thereby facilitating the development of innovative therapeutic strategies that target perturbations in the pancreatic microenvironment.

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Section: Discussionmentioning

confidence: 99%

The Pivotal Role of Macrophages in the Pathogenesis of Pancreatic Diseases

Ryu,

Lee

2024

IJMS

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“…According to our experience, EUS fine needle biopsy was applied more frequently to exclude other malignant pancreatic lesions than to confirm pancreatic SPN diagnosis. Research has also been conducted on the non-invasive detection of pancreatic cancer utilizing fecal microbiota signatures in conjunction with serum levels of CA19-9 [ 25 , 26 ]. This method could potentially improve our preoperative differentiation between SPNs and pancreatic cancer.…”

Section: Discussionmentioning

confidence: 99%

Surgical Outcomes of Pancreatic Solid Pseudopapillary Neoplasm: Experiences of 24 Patients in a Single Institute

Ku,

Cheng,

Chen

et al. 2024

Medicina

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Background and Objectives: The pancreatic solid pseudopapillary neoplasm (SPN), a rare tumor predominantly affecting young women, has seen an increased incidence due to improved imaging and epidemiological knowledge. This study aimed to understand the outcomes of different interventions, possible complications, and associated risk factors. Materials and Methods: This study retrospectively analyzed 24 patients who underwent pancreatic surgery for SPNs between September 1998 and July 2020. Results: Surgical intervention, typically required for symptomatic cases or pathological confirmation, yielded favorable outcomes with a 5-year survival rate of up to 97%. Despite challenges in standardizing preoperative evaluation and follow-up protocols, aggressive complete resection showed promising long-term survival and good oncological outcomes. Notably, no significant differences were found between conventional and minimally invasive (MI) surgery in perioperative outcomes. Histopathological correlations were lacking in prognosis and locations. Among the patients, one developed diffuse liver metastases 41 months postoperatively but responded well to chemotherapy and transcatheter arterial chemoembolization, with disease stability observed at 159 postoperative months. Another patient developed nonalcoholic steatohepatitis after surgery and underwent liver transplantation, succumbing to poor medication adherence 115 months after surgery. Conclusions: These findings underscore the importance of surgical intervention in managing SPNs and suggest the MI approach as a viable option with comparable outcomes to conventional surgery.

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“…The results seem promising. The importance of FMT in pancreatic disorders is summarized in this interesting review [270]. It has been widely demonstrated that diet has a significant impact on the composition and stability of the GM, and different diets affect the species of microorganisms that populate the gut differently, changing its internal balance [271].…”

Section: Fmt In Hepatic and Pancreatic Disease: Clinical Trialsmentioning

confidence: 99%

Gut–Liver–Pancreas Axis Crosstalk in Health and Disease: From the Role of Microbial Metabolites to Innovative Microbiota Manipulating Strategies

Marroncini,

Naldi,

Martinelli

et al. 2024

Biomedicines

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The functions of the gut are closely related to those of many other organs in the human body. Indeed, the gut microbiota (GM) metabolize several nutrients and compounds that, once released in the bloodstream, can reach distant organs, thus influencing the metabolic and inflammatory tone of the host. The main microbiota-derived metabolites responsible for the modulation of endocrine responses are short-chain fatty acids (SCFAs), bile acids and glucagon-like peptide 1 (GLP-1). These molecules can (i) regulate the pancreatic hormones (insulin and glucagon), (ii) increase glycogen synthesis in the liver, and (iii) boost energy expenditure, especially in skeletal muscles and brown adipose tissue. In other words, they are critical in maintaining glucose and lipid homeostasis. In GM dysbiosis, the imbalance of microbiota-related products can affect the proper endocrine and metabolic functions, including those related to the gut–liver–pancreas axis (GLPA). In addition, the dysbiosis can contribute to the onset of some diseases such as non-alcoholic steatohepatitis (NASH)/non-alcoholic fatty liver disease (NAFLD), hepatocellular carcinoma (HCC), and type 2 diabetes (T2D). In this review, we explored the roles of the gut microbiota-derived metabolites and their involvement in onset and progression of these diseases. In addition, we detailed the main microbiota-modulating strategies that could improve the diseases’ development by restoring the healthy balance of the GLPA.

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The Importance of Microbiota and Fecal Microbiota Transplantation in Pancreatic Disorders

Cited by 15 publications

References 100 publications

The Pivotal Role of Macrophages in the Pathogenesis of Pancreatic Diseases

The Pivotal Role of Macrophages in the Pathogenesis of Pancreatic Diseases

Surgical Outcomes of Pancreatic Solid Pseudopapillary Neoplasm: Experiences of 24 Patients in a Single Institute

Gut–Liver–Pancreas Axis Crosstalk in Health and Disease: From the Role of Microbial Metabolites to Innovative Microbiota Manipulating Strategies

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