The importance of miRNAs and epigenetics in acute lymphoblastic leukemia prognosis

Ranjbar, Reza; Karimian, Ansar; Fard, Arad Aghaie; Tourani, Mehdi; Majidinia, Maryam; Jadidi‐Niaragh, Farhad; Yousefi, Bahman

doi:10.1002/jcp.26510

Cited by 29 publications

(15 citation statements)

References 130 publications

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“…MiRNAs are small non-coding RNAs of about 19–24 nucleotides, which inhibit the translation of proteins by binding to 3′-UTR of the target mRNA. Some studies have also found that miRNAs can interact directly with proteins to regulate gene expression [1] or influence the epigenetic mechanisms [2]. As a non-invasive blood biomarker, miRNAs are relatively stable and easy to detect.…”

Section: Introductionmentioning

confidence: 99%

Research advances in the detection of miRNA

Tian

et al. 2019

Journal of Pharmaceutical Analysis

289

152

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MicroRNAs (miRNAs) are a family of endogenous, small (approximately 22 nucleotides in length), noncoding, functional RNAs. With the development of molecular biology, the research of miRNA biological function has attracted significant interest, as abnormal miRNA expression is identified to contribute to serious human diseases such as cancers. Traditional methods for miRNA detection do not meet current demands. In particular, nanomaterial-based methods, nucleic acid amplification-based methods such as rolling circle amplification (RCA), loop-mediated isothermal amplification (LAMP), strand-displacement amplification (SDA) and some enzyme-free amplifications have been employed widely for the highly sensitive detection of miRNA. MiRNA functional research and clinical diagnostics have been accelerated by these new techniques. Herein, we summarize and discuss the recent progress in the development of miRNA detection methods and new applications. This review will provide guidelines for the development of follow-up miRNA detection methods with high sensitivity and specificity, and applicability to disease diagnosis and therapy.

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Section: Introductionmentioning

confidence: 99%

Research advances in the detection of miRNA

Tian

et al. 2019

Journal of Pharmaceutical Analysis

289

152

View full text Add to dashboard Cite

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“…In their roles in cancer, miRNAs are found to act as both oncogenes, by stimulating tumor growth and metastasis, and tumor suppressor genes, by inhibiting tumor cell proliferation and dissemination, as well as in inducing apoptosis [ 36 , 37 , 38 ]. Recent studies have demonstrated that miRNAs directly interact with proteins, thereby either regulating gene expression or influencing epigenetic mechanisms [ 39 , 40 , 41 ].…”

Section: Mirnas and Nutritionmentioning

confidence: 99%

The Role of miR-155 in Nutrition: Modulating Cancer-Associated Inflammation

et al. 2021

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Nutrition plays an important role in overall human health. Although there is no direct evidence supporting the direct involvement of nutrition in curing disease, for some diseases, good nutrition contributes to disease prevention and our overall well-being, including energy level, optimum internal function, and strength of the immune system. Lately, other major, but more silent players are reported to participate in the body’s response to ingested nutrients, as they are involved in different physiological and pathological processes. Furthermore, the genetic profile of an individual is highly critical in regulating these processes and their interactions. In particular, miR-155, a non-coding microRNA, is reported to be highly correlated with such nutritional processes. In fact, miR-155 is involved in the orchestration of various biological processes such as cellular signaling, immune regulation, metabolism, nutritional responses, inflammation, and carcinogenesis. Thus, this review aims to highlight those critical aspects of the influence of dietary components on gene expression, primarily on miR-155 and its role in modulating cancer-associated processes.

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“…Small noncoding RNAs with a length of 19–24 nucleotides are known as miRNAs, which suppresses the protein translation via binding to 3′‐UTR of the mRNAs 111 . It has been shown that the direct interaction of miRNAs with proteins has regulated gene expression and affected the epigenetic mechanisms as well 112,113 . miRNAs are noninvasive blood biomarkers that are quite stable and easily separable.…”

Section: Mirnas Detectionmentioning

confidence: 99%

Autophagy regulation by microRNAs: Novel insights into osteosarcoma therapy

et al. 2020

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Osteosarcoma (OS) is a kind of primary bone cancer that is considered as the leading cause of children death. Surgery and chemotherapy are considered as common treatment approaches for OS; the rate of survival for patients is almost 60-70%. Besides the used therapeutic approaches, it seems that there is a crucial need to launch new treatments for OS. In this regard, more understanding about cellular and molecular pathways involved in OS can contribute to recovery and develop new therapeutic platforms. Autophagy is a cellular machinery that digests and degrades dysfunctional proteins and organelles, so it can regulate the cell proliferation and survival. Most of the time, OS cells use autophagy to increase their survival and proliferation and to gain the ability to resist chemotherapy. Although, there are several controversial evidences on how OS cells use autophagy. A variety of cellular and molecular pathways, that is, microRNAs (miRNAs) can modulate autophagy. MiRNAs are some endogenous, approximately 22 nucleotide RNAs that have an important role in posttranscriptional regulation of mRNAs by targeting them. There are many evidences that the various miRNA expressions in OS cells are dysregulated, so it can propel a normal cell to cancerous one by influencing the cell survival, apoptosis, and autophagy, and eventually increased chemoresitance. Hence, miRNAs can be considered as new biomarkers for OS diagnosis, and according to the role of autophagy in OS progression, miRNAs can use inhibiting or promoting autophagy agents. The present review summarizes the effects of

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The importance of miRNAs and epigenetics in acute lymphoblastic leukemia prognosis

Cited by 29 publications

References 130 publications

Research advances in the detection of miRNA

Research advances in the detection of miRNA

The Role of miR-155 in Nutrition: Modulating Cancer-Associated Inflammation

Autophagy regulation by microRNAs: Novel insights into osteosarcoma therapy

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