The Importance of Obesity in the Development of Coronary Risk Factors and Disease: The Epidemiologic Evidence

Hubert, Helen B.

doi:10.1146/annurev.pu.07.050186.002425

Cited by 58 publications

(25 citation statements)

References 37 publications

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“…Por outro lado, a obesidade, isolada ou associada à hipertensão e/ou ao alcoolismo, foi o fator de risco mais relevante de dislipidemias encontrado no presente trabalho, coincidindo com resultados de outras pesquisas e com trabalho anterior, realizado em uma população do Município de São Paulo 4,11,12,14,16,17,24,26,28,35 .…”

Section: Resultsunclassified

“…As dislipidemias são causas fundamentais de doenças coronarianas ateroscleróticas 1,7,8,10,16,30,32,34 . A prevenção dessas morbidades e dos fatores de risco, que se apresentem como determinantes ou associados às mesmas, tem aumentado consideravelmente a esperança de vida de grupos populacionais em fase produtiva, principalmente de países desenvolvidos, onde há muito se realizam pesquisas epidemiológicas, pelos estudos longitudinais e transversais, seguidas da aplicação de programas de intervenção 15,19,21 .…”

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Dislipidemias e alguns fatores de risco associados em uma população periférica da Região Metropolitana de São Paulo, SP - Brasil. um estudo piloto

et al. 1989

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RESUMO: Realizou-se levantamento da prevalência de dislipidemias e alguns fatores de risco (hipertensão, obesidade e alcoolismo), em uma população típica da periferia do Município de São Paulo, SP (Brasil). A prevalência de um ou mais fatores de risco foi maior do que 50% em todos os grupos etários. No que concerne às dislipidemias propriamente ditas, foi de aproximadamente 49%, 58% e 57% nos grupos etários de 20 a 39 anos, 40 a 59 anos e 60 anos e mais, respectivamente. A dislipidemia mais freqüente foi devido a baixos níveis de HDL-colesterol, principalmente nos mais jovens, entre 29 e 39 anos. Nos outros dois grupos etários houve prevalência maior de "outras dislipidemias". A obesidade isolada ou associada foi o fator de risco mais relevante na população estudada. Levanta-se a hipótese de que as dislipidemias podem constituir-se em grave problema de Saúde Pública nas populações periféricas da cidade de São Paulo.

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Section: Resultsunclassified

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Dislipidemias e alguns fatores de risco associados em uma população periférica da Região Metropolitana de São Paulo, SP - Brasil. um estudo piloto

et al. 1989

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“…No study has yet applied a reference method suitable for assessing key features or changes in the FFM, such as its hydration fraction (HF ffm ) or density (D ffm ). An increase in central fat mass has also been indicated [10], which is associated with cardiovascular disease and increased morbidity and mortality [11,12]. It is possible, therefore, that any increase in visceral fat deposition due to insulin treatment could offset the advantage of improved glycaemic control.…”

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confidence: 99%

Use of a reference four-component model to define the effects of insulin treatment on body composition in type 2 diabetes: the ?Darwin study?

et al. 2005

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Aims: To define the effects of insulin treatment on body composition and fat distribution, and investigate the potential role of body weight (BWt) gain predictors in patients with poorly controlled type 2 diabetes. , with the FFM increase due solely to total body water [TBW; +2.4 (1.5) l], as there were no detectable changes in total body protein or bone mineral, thereby increasing FFM hydration by 1.3%. More body fat was deposited centrally in patients receiving insulin alone than those receiving insulin with an oral hypoglycaemic agent (metformin). Daily insulin dose, HbA 1 c and hip circumference were independent predictors of BWt gain. Conclusions: Insulin treatment increased fat and FFM similarly in poorly controlled type 2 diabetes patients, with the FFM gain due entirely to TBW. The possible role of metformin in reducing central fat accumulation following insulin treatment warrants further investigation into its mechanism and potential long-term benefits.

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“…O besity is related to abnormal lipid and carbohydrate metabolism and is predictive of subsequent cardiovascular disease. 1 • 2 However, the associations have often been fairly weak or have been observed only over long periods of follow-up, 3 ' 4 and obesity may be a risk factor in only specific subgroups of overweight persons. 5 Much evidence suggests that high risk obese individuals are characterized by their distribution of adipose tissue.…”

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Body fat distribution, plasma lipids, and lipoproteins.

et al. 1988

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The relation of body fat distribution as measured by the ratio of waist to hip circumferences (WHR) to plasma levels of lipids and lipoproteins was studied In 713 men and 520 women who were employed by two Milwaukee companies. Quetelet Index (kg/m 2 ), waist girth, hip girth, and WHR were each positively related to levels of total cholesterol, trlglycerldes, apollpoproteln B, and the ratio of total to high density llpoproteln (HDL) cholesterol. In addition, the anthropometrlc measures were Inversely associated with levels of HDL cholesterol. (Controlling for age, alcohol intake, exercise level, current smoking status, and oral contraceptive use only slightly reduced the strength of the correlations.) In addition, WHR and Quetelet Index were Independently related to llpld and llpoproteln levels, and the magnitudes of the associations were roughly equivalent For example, the mean (covarlate-adjusted) trlglycerlde level among men In the upper tortile of the Quetelet Index was 37 mg/dl higher than for men in the lower tertlle of the Quetelet Index; the corresponding difference according to WHR tertlles (upper to lower) was 39 mg/dl (p<0.01 for both effects). These findings Indicate that In healthy men and women a less favorable lipid and llpoproteln profile Is associated with elevated levels of both Quetelet Index and WHR.

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The Importance of Obesity in the Development of Coronary Risk Factors and Disease: The Epidemiologic Evidence

Cited by 58 publications

References 37 publications

Dislipidemias e alguns fatores de risco associados em uma população periférica da Região Metropolitana de São Paulo, SP - Brasil. um estudo piloto

Dislipidemias e alguns fatores de risco associados em uma população periférica da Região Metropolitana de São Paulo, SP - Brasil. um estudo piloto

Use of a reference four-component model to define the effects of insulin treatment on body composition in type 2 diabetes: the ?Darwin study?

Body fat distribution, plasma lipids, and lipoproteins.

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