The Importance of Radiotherapy in the Treatment of Ankylosing Spondylitis

Richmond, J. Jackson

doi:10.1177/003591575104400608

Cited by 4 publications

(3 citation statements)

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“…[ 50 ] While different methods existed for radiation therapy in AS patients, treatment typically involved X-ray exposure at a predetermined dosage of the entire spine or the lower lumbar spine in addition to the SI joints, and was thought to reduce inflammatory activity in the bone and joints of the spine. [ 49 ] Patients demonstrated substantially recovered flexibility in their spine and a considerable reduction in pain following radiation therapy. [ 34 , 49 ] Radiation therapy did not alter the progression of the disease, but was heavily embraced for symptomatic benefit.…”

Section: Treatmentsmentioning

confidence: 99%

“…[ 49 ] Patients demonstrated substantially recovered flexibility in their spine and a considerable reduction in pain following radiation therapy. [ 34 , 49 ] Radiation therapy did not alter the progression of the disease, but was heavily embraced for symptomatic benefit. [ 34 , 49 , 50 ] Unfortunately, as secondary, long-term effects of radiation appeared, the treatment is no longer utilized.…”

Section: Treatmentsmentioning

confidence: 99%

“…[ 34 , 49 ] Radiation therapy did not alter the progression of the disease, but was heavily embraced for symptomatic benefit. [ 34 , 49 , 50 ] Unfortunately, as secondary, long-term effects of radiation appeared, the treatment is no longer utilized. [ 3 , 50 ] A study of nearly 15,000 patients treated with radiation therapy between the years 1935 and 1954 found an increased incidence of leukemia, aplastic anemia, and other cancers associated with the site of radiation.…”

Section: Treatmentsmentioning

confidence: 99%

See 2 more Smart Citations

A brief human history of ankylosing spondylitis: A scoping review of pathogenesis, diagnosis, and treatment

Murphy

Nguyen

Singh

et al. 2022

Surgical Neurology International

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Background: Ankylosing spondylitis (AS) is a chronic, progressive, inflammatory disease of the spine and SI joints. Diagnostic criteria and treatments have continued to evolve, necessitating a historical compendium of AS and its management. This paper aims to review the historical context underlying the discovery of AS, as well as the major diagnostic and therapeutic discoveries in the last two centuries. Methods: A scoping review of the literature pertaining to AS was performed via the Pubmed, Scopus, and Web of Science databases. Future directions of AS treatments were assessed by querying the clinicaltrials.gov website. Results: The history of AS can be traced as far back as ancient Egypt (as evidenced by the discovery of its presence in ancient Egyptian mummies) to the late 20th century, when the inherited nature of AS was linked to a genetic factor, HLA-B27. Each discovery made throughout the years led to further investigations into the pathophysiology, diagnosis, and treatment of AS. The criteria to differentiate AS from rheumatoid arthritis were first reported in 1893. Since then, diagnostic criteria for AS have undergone a series of changes before the present-day diagnostic criteria for AS were ultimately determined in 2009 by the Assessment of Spondyloarthritis International Society. Conclusion: As the pathophysiology of AS is better understood, healthcare providers are able to diagnose and treat the condition more effectively. In particular, earlier diagnosis and multiple treatment options have facilitated efficient and more effective treatment.

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Section: Treatmentsmentioning

confidence: 99%