The importance of serum albumin determination method to classify patients based on nutritional status

Alcorta, Marta Duque; Alvarez, P. Chanca; Cabetas, R. Nuñez; Martín, María José Alcaide; Valero, María Angeles; Candela, Carmen Gómez

doi:10.1016/j.clnesp.2018.03.124

Cited by 21 publications

(10 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Third, serum albumin levels were measured using the bromocresol green method. Serum albumin measurements using bromocresol green are associated with non-specific binding and a proportional bias between the two colorimetric and immunologic methods has been reported [38]. A previous study showed that the bromocresol green method led to a mean bias of 0.62 g/dL compared to the immunologic method, which resulted in an inappropriate treatment decision for 59% of patients with hypoalbuminemia [39].…”

Section: Plos Onementioning

confidence: 99%

Comparison of lean mass indices as predictors of mortality in incident peritoneal dialysis patients

2021

View full text Add to dashboard Cite

Background Few studies have considered optimal adjusted lean mass indices for prediction of clinical outcomes in peritoneal dialysis (PD) patients. We aimed to evaluate clinical variables using various adjusted indices in PD patients. Methods Total 528 incident PD patients were included. Lean mass was measured using dual energy X-ray absorptiometry. Appendicular lean mass (ALM) was calculated using the sum for both upper and lower extremities. Each ALM index was calculated using ALM per body weight (ALM/BW), height squared (ALM/Ht2), or body mass index (ALM/BMI). Limb/trunk lean mass (LTLM) ratio was defined as the sum for both upper and lower extremities divided by trunk lean mass. Results A total of 528 patients were analyzed men: 286, women: 242. In area under the receiver operating characteristic curve analyses, LTLM alone was associated with 1 year mortality. In the LTLM ratio, the cut-off value for 1-year mortality was ≤ 0.829 in men and ≤ 0.717 in women, respectively. In both sexes, LTLM ratio alone showed statistical significance in all-cause mortality in both univariate and multivariate Cox-regression analyses. Compared with other indices, the LTLM ratio was independent of edema and fat in both sexes. Edema- and C-reactive protein-adjusted correlation analysis showed that LTLM ratio alone was associated with serum albumin in men. Although statistical significance was not obtained for women, the correlation coefficient was highest for the LTLM ratio compared with other indices. Conclusion Among various indices using lean mass, LTLM ratio was independent of volume status and fat mass and was associated with mortality in incident PD patients.

show abstract

Section: Plos Onementioning

confidence: 99%

Comparison of lean mass indices as predictors of mortality in incident peritoneal dialysis patients

2021

View full text Add to dashboard Cite

show abstract

“…Recently, a similar intervention demonstrated the slight reduction of serum MPO activity triggered by the combination of Taurine and ME in older persons [26]. Instead, albumin concentrations are currently used for the assessment of the nutritional status of an individual, and low albumin concentrations have been associated with increased mortality after correlation for age, body mass index (BMI), gender, and several chronic comorbidities [27]. In this sense, multifatorial interventions programs (MIP, exercise plus protein suplmentattion) that target to maintain (or even increase) albuminemia in older persons could characterize an important strategy to diminish the harmful effects of aging and its comorbidities [28].…”

Section: Introductionmentioning

confidence: 99%

Effect of Training-Detraining Phases of Multicomponent Exercises and BCAA Supplementation on Inflammatory Markers and Albumin Levels in Frail Older Persons

Caldo-Silva

Furtado

Chupel³

et al. 2021

Nutrients

View full text Add to dashboard Cite

Nowadays, it is accepted that the regular practice of exercise and branched-chain amino acids supplementation (BCAAs) can benefit the immune responses in older persons, prevent the occurrence of physical frailty (PF), cognitive decline, and aging-related comorbidities. However, the impact of their combination (as non-pharmacological interventions) in albumin and the inflammatory markers is not fully understood. Therefore, we investigated the effect of a 40-week multifactorial intervention [MIP, multicomponent exercise (ME) associated or not with BCAAs] on plasma levels of inflammatory markers and albumin in frail older persons (≥75 years old) living at residential care homes (RCH). This study consisted of a prospective, naturalistic, controlled clinical trial with four arms of multifactorial and experimental (interventions-wahshout-interventions) design. The intervention groups were ME + BCAAs (n = 8), ME (n = 7), BCAAs (n = 7), and control group (n = 13). Lower limb muscle-strength, cognitive profile, and PF tests were concomitantly evaluated with plasma levels of albumin, anti- and pro-inflammatory cytokines [Interleukin-10 (IL-10) and Tumor Necrosis Factor-alpha (TNF-α) respectively], TNF-α/IL-10 ratio, and myeloperoxidase (MPO) activity at four different time-points: Baseline (T1), after 16 weeks of multifactorial intervention (T2), then after a subsequent 8 weeks washout period (T3) and finally, after an additional 16 weeks of multifactorial intervention (T4). Improvement of cognitive profile and muscle strength-related albumin levels, as well as reduction in the TNF-α levels were found particularly in ME plus BCAAs group. No significant variations were observed over time for TNF-α/IL-10 ratio or MPO activity. Overall, the study showed that MIP triggered slight alterations in the inflammatory and physical function of the frail older participants, which could provide independence and higher quality of life for this population.

show abstract

“…The serum albumin test is also widely available, and can be performed by a laboratory or as a point-of-care assay. 16,17 Serum albumin measurements are also cost-effective, with current costs per test invoiced at approximately US$ 3 in our setting. This cost is negligible when compared to the excessive costs required to treat SSI.…”

Section: Discussionmentioning

confidence: 99%

A comparison of preoperative hypoalbuminaemia with the NNIS and SENIC risk scores for the prediction of surgical site infection in a South African setting

Naidoo

Madiba

Moodley

2020

The Journal of Medical Laboratory Science and Technology of Sou

View full text Add to dashboard Cite

Introduction: Preoperative hypoalbuminaemia is a risk factor for surgical site infection (SSI) in the South African (SA) setting. However, the predictive accuracy of preoperative hypoalbuminaemia has not been tested against established SSI risk stratification models in our setting, which could have important implications for SSI prevention strategies. With reference to SSI in SA settings, the study objective was to compare the overall predictive accuracy of preoperative hypoalbuminaemia with that obtained for the SENIC/NNIS risk scores. Method: This was a sub-analysis of a pre-existing laparotomy patient registry (N = 439). Variables collected as part of the registry included preoperative serum albumin measurements and all parameters of the SENIC/NNIS risk scores. Preoperative hypoalbuminaemia was defined as preoperative serum albumin of < 30 g/L. The study outcome was SSI up to 30 days postoperatively. Overall predictive accuracy was determined through a receiver operator-characteristic (ROC) curve analysis, with results presented as C-statistics (95% confidence intervals [CI]). Results: The C-statistics obtained for preoperative hypoalbuminaemia, the SENIC risk score, and the NNIS risk score were 0.677 (CI: 0.609–0.746), 0.652 (CI: 0.582–0.721), and 0.634 (CI: 0.563–0.705). Conclusion: All three methods display similar predictive accuracy for SSI. However, preoperative hypoalbuminaemia has several practical advantages over the SENIC/NNIS scores which must be considered.

show abstract

The importance of serum albumin determination method to classify patients based on nutritional status

Cited by 21 publications

References 24 publications

Comparison of lean mass indices as predictors of mortality in incident peritoneal dialysis patients

Comparison of lean mass indices as predictors of mortality in incident peritoneal dialysis patients

Effect of Training-Detraining Phases of Multicomponent Exercises and BCAA Supplementation on Inflammatory Markers and Albumin Levels in Frail Older Persons

A comparison of preoperative hypoalbuminaemia with the NNIS and SENIC risk scores for the prediction of surgical site infection in a South African setting

Contact Info

Product

Resources

About