The importance of serum biglycan levels as a fibrosis marker in patients with chronic hepatitis B

Çiftçiler, Rafiye; Özeni̇rler, Seren; Yücel, Ayşegül Atak; Cengiz, Mustafa; Erkan, Gülbanu; Büyükdemirci, Erkan; Sönmez, Cemile; Esendağlı, Güldal

doi:10.1002/jcla.22109

Cited by 19 publications

(13 citation statements)

References 23 publications

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“…Most HCCs develop from hepatofibrosis, and the potential curative treatment options are limited (Kimhofer et al, 2015), so it is quite important to look for biomarkers for hepatofibrosis. It has been reported that some substances, such as angiopoietin-like protein 2 or serum biglycan, can be biomarkers for liver fibrosis, but the area under the ROC curve for the reports were lower than 0.9 (Ciftciler et al, 2017;Deng et al, 2017). In this study, the area under the ROC curve for ADHI and ADHII was greater than 0.9.…”

Section: Discussionmentioning

confidence: 99%

Higher Activity of Alcohol Dehydrogenase Is Correlated with Hepatic Fibrogenesis

Gao

et al. 2018

J Pharmacol Exp Ther

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Hepatofibrosis can progress to cirrhosis and hepatocellular carcinoma (HCC). Prevention, stabilization, and reversal of disease progression are vital for patients with hepatofibrosis, and identifying the risk factors for hepatofibrosis is urgently needed. In this study, we examined the activities of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) in the fibrotic livers of HCC patients ( = 88) and comparied these results with activities in patients with normal livers ( = 74). A fibrosis-carcinoma rat model was used to study the activity of ADH in fibrosis and HCC and the relationship between innate ADH activity and the extent of hepatofibrosis or HCC. Substantial interindividual variations were found in the activities of ADH and ALDH in normal livers. The activity levels of total ADH, ADHI, and ADHII in fibrotic livers were significantly higher than those in normal livers ( < 0.001), whereas the activity of ALDH was slightly greater. The positive rates of ADHI and ADHII were 84.1% and 77.3%, respectively; the areas under the receiver operator characteristics (ROC) curve were 0.943 and 0.912, respectively. For the rat model compared with controls, ADH activity in liver was significantly increased at the fibrotic and HCC stages, and no significant difference was noted between ADH activity in the liver at these two stages. The innate activity of ADH in serum was well correlated with the extent of hepatofibrosis as indicated by Masson area%, Ki67%, proliferating cell nuclear antigen %, and GST-p average density at fibrotic stage but not at HCC stage. A higher level of activity of ADH is a risk factor for hepatofibrogenesis and might be a prevention target for hepatofibrosis.

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Section: Discussionmentioning

confidence: 99%

Higher Activity of Alcohol Dehydrogenase Is Correlated with Hepatic Fibrogenesis

Gao

et al. 2018

J Pharmacol Exp Ther

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“…Serum biglycan levels have been studied in relation to other diseases, such as hepatitis B and endometrial cancer [41,42], but not in relation to preterm labor. We previously demonstrated that serum biglycan concentrations in early pregnancy are increased prior to presentation with PPROM when compared with those in controls that went on to deliver at term [27].…”

Section: Discussionmentioning

confidence: 99%

Serum Decorin, Biglycan, and Extracellular Matrix Component Expression in Preterm Birth

et al. 2020

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Preterm birth is a leading cause of infant morbidity and mortality. Decorin and biglycan are proteoglycans that play key roles in maintaining the connective tissue matrix and tensile strength of human fetal membranes and have been previously linked to PPROM. Extracellular matrix proteins, such as matrix metalloproteinase 2 (MMP-2), matrix metalloproteinase 9 (MMP-9), TIMP metallopeptidase inhibitor 1 (TIMP-1), TIMP metallopeptidase inhibitor 2 (TIMP-2), and collagen VI (COL-6), have also been linked to PPROM and may have utility in a serum-based screening model for this condition. To define the natural course of serum decorin and biglycan expression throughout the duration of healthy pregnancy, to explore patterns of serum decorin and biglycan expression in serum of asymptomatic women who go on to develop spontaneous preterm labor, and to investigate the potential role for matrix metalloproteinases, their inhibitors, and collagen VI in a serum-based screening model to predict PPROM. Serum decorin level decreases less than 1% per week, and serum biglycan decreases by 2.9% per week over the duration of healthy pregnancy. Serum decorin and biglycan concentrations do not differ in spontaneous preterm labor cases compared with those in controls. Mean concentrations of MMP-2, MMP-9, TIMP-1, TIMP-2, and COL-6 do not differ in PPROM cases compared with those in controls. We have demonstrated that serum decorin and biglycan concentrations remain stable throughout the duration of normal pregnancy and are not early indicators of preterm labor, while common MMPs, TIMPs, and collagen VI are not early indicators of PPROM.

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“…To the best of our knowledge, there is only one study that evaluates BGN as a non-invasive marker for liver fibrosis assessment in human CHB infection,6 but no study about its role in human CHC infection. The BGN level increased significantly in the CHB group when compared with the control group (p<0.001), in agreement with the result of Ciftciler et al ,6 but there is no significant difference in the BGN level between the CHC group when compared with the control group (p<0.96). Liver biopsy was performed to assess the degree of liver fibrosis according to the Ishak scale and classify fibrosis into six stages 19.…”

Section: Discussionmentioning

confidence: 99%

Significance of biglycan and osteopontin as non-invasive markers of liver fibrosis in patients with chronic hepatitis B virus and chronic hepatitis C virus

Sobhy

Fakhry

Azeem

et al. 2019

Journal of Investigative Medicine

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Several studies were performed to evaluate the degree of liver fibrosis by non-invasive markers. We aimed to assess the diagnostic value of both biglycan (BGN) and osteopontin (OPN) as non-invasive markers of hepatic fibrosis in patients with chronic hepatitis B (CHB) and chronic hepatitis C (CHC). This study was performed on 100 patients with CHB virus, 100 patients with CHC virus and 100 normal controls. All participants were subjected to the following laboratory tests: hemoglobin, platelet, alanine aminotransferase, aspartate aminotransferase, albumin, international normalized ratio, HBs Ag, hepatitis C virus (HCV) antibody, hepatitis B virus DNA, HCV RNA, liver biopsy, BGN and OPN. We found that BGN level was significantly increased in the CHB group compared with the controls (p<0.001), but the level was not different between the CHC group and the controls (p<0.96). OPN was increased in both the CHB and CHC groups compared with the controls (p<0.001). Positive correlation was found between fibrosis stages and BGN level of the CHB group (r=0.64; p<0.001) and between fibrosis stages and OPN level of the CHB (r=0.63; p<0.001) and CHC (r=0.59; p<0.03) groups. The area under the curve (AUC), sensitivity and specificity of BGN were 1.0, 100% and 100% in predicting fibrosis in patients with CHB, and 0.50, 26% and 78% in predicting fibrosis in patients with CHC. OPN had an AUC of 0.997, sensitivity of 96% and specificity of 100% in predicting fibrosis in patients with CHB, and 0.974, 96.5% and 100% in predicting fibrosis in patients with CHC. In conclusion, BGN and OPN could be considered non-invasive markers for liver fibrosis assessment.

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The importance of serum biglycan levels as a fibrosis marker in patients with chronic hepatitis B

Abstract: Serum biglycan might be used as a non-invasive marker of liver fibrosis. Further studies are needed to evaluate the usefulness of this marker.

Cited by 19 publications

References 23 publications

Higher Activity of Alcohol Dehydrogenase Is Correlated with Hepatic Fibrogenesis

Higher Activity of Alcohol Dehydrogenase Is Correlated with Hepatic Fibrogenesis

Serum Decorin, Biglycan, and Extracellular Matrix Component Expression in Preterm Birth

Significance of biglycan and osteopontin as non-invasive markers of liver fibrosis in patients with chronic hepatitis B virus and chronic hepatitis C virus

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