The Importance of Sodium Pyruvate in Assessing Damage Produced by Hydrogen Peroxide

Formation and Conversion of Oxygen Metabolites by Lactococcus lactis subsp. lactis ATCC 19435 under Different Growth Conditions

“…The use of pyruvate as a protective agent has been studied for a long time, especially by chemists and medical biologists (14,16,39,40). Although it has been suggested by Grufferty and Condon (18), nobody has made the link between metabolically generated pyruvate and H 2 O 2 destruction for lactococci.…”

“…The kinetics of the reaction of pyruvate with H 2 O 2 has been studied before under conditions physicochemically different from those used here (16). Therefore, the rate constant was measured aerobically at 30°C by determining the conversion of H 2 O 2 at discrete time intervals in 50 ml of water, in TEA buffer (50 mM, pH 7.2), and in 10 ml of TEA buffer plus CE.…”

Physiology and evolution of nitrate acquisition in Prochlorococcus

“…Axenic Prochlorococcus do not grow from such low cell densities in Pro99 medium without 'helper' heterotrophic bacteria (Morris et al, 2008(Morris et al, , 2011; however, they do grow when diluted into ProMM. The main ingredient in ProMM that promotes the growth of cells from low densities is pyruvate, and we suspect that in this context pyruvate serves as a potent hydrogen peroxide scavenger (Giandomenico et al, 1997). Wells contaminated with heterotrophic bacteria were identified by the appearance of turbidity.…”

Blockade of quinolinic acid-induced neurotoxicity by pyruvate is associated with inhibition of glial activation in a model of Huntington's disease

“…Pyruvate, the final metabolite of glycolysis, serves as a cellular energy substrate (Tsacopoulos and Magistretti, 1996) and also exhibits antioxidant activity (Giandomenico et al, 1997). In vitro, pyruvate protects against NMDA or zinc-mediated cell death by enhancing energy metabolism (Maus et al, 1999;Sheline et al, 2000).…”