The Importance of the Assessment of Pulmonary Function in COPD

Bailey, Kristina L.

doi:10.1016/j.mcna.2012.04.011

Cited by 46 publications

(34 citation statements)

References 18 publications

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“…21 But pulmonary function is influenced by age, sex, height and ethnicity. 21 But pulmonary function is influenced by age, sex, height and ethnicity.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Function Parameters in High-resolution Computed Tomography Phenotypes of Chronic Obstructive Pulmonary Disease

Sun

Shen

Wan

et al. 2015

The American Journal of the Medical Sciences

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“…21 But pulmonary function is influenced by age, sex, height and ethnicity. 21 But pulmonary function is influenced by age, sex, height and ethnicity.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Function Parameters in High-resolution Computed Tomography Phenotypes of Chronic Obstructive Pulmonary Disease

Sun

Shen

Wan

et al. 2015

The American Journal of the Medical Sciences

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“…[5] Spirometry, which is widely available, is the easiest and most common method of testing pulmonary function. Spirometric indices, primarily forced expiratory volume in 1 sec (FEV1), are used to monitor progression and describe severity in chronic respiratory diseases such as cystic fibrosis or COPD [6–8]. In PCD patients, several studies have reported results of lung function measurements, however their findings are contradictory, ranging from normal lung function to significant impairment.…”

Section: Introductionmentioning

confidence: 99%

Spirometric indices in primary ciliary dyskinesia: systematic review and meta-analysis

Halbeisen

Jose

Jong

et al. 2018

Preprint

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Take home message: Spirometric indices of PCD patients vary between published studies, which not only suggests the possibility of methodological differences between centres, but also real differences in disease expression based on genotype-phenotype associations. 2 AbstractPrimary ciliary dyskinesia (PCD) is a genetic, heterogeneous disease caused by dysfunction of cilia. Evidence is sparse and reports of lung function of PCD patients ranges from normal to severe impairment. This systematic review and meta-analysis of studies of lung function of PCD patients examines the spirometric indices of PCD patients and differences by age group and sex.We searched PubMed, Embase, and Scopus for studies that described lung function in ≥ 10 patients with PCD. We performed meta-analyses and metaregression to explain heterogeneity. We included 24 studies, ranging from 13-158 patients per study. The most commonly reported spirometric indices were forced expiratory volume in 1 sec (FEV1) and forced vital capacity (FVC) presented as mean and standard deviation of percent of predicted values. We found considerable heterogeneity for both parameters (I 2 range 94-96%). The heterogeneity remained when we stratified the analysis by age; however, FEV1 in adult patients was lower. Even after taking into account explanatory factors, the largest part of the between-studies variance remained unexplained.Heterogeneity could be explained by genetic differences between study populations, methodological factors related to the variability of study inclusion criteria, or details on the performance and evaluation of lung function measurements that we could not account for. Prospective studies therefore need to use standardised protocols and international reference values. These results underline the possibility of distinct PCD phenotypes as in other chronic respiratory diseases. Detailed characterisation of these phenotypes and related genotypes is needed in order to better understand the natural history of PCD.

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“…The DLCO provides clinical insights complimentary to those obtained by spirometry and lung volume measurements, for example, in discriminating asthma from chronic obstructive pulmonary disease (COPD), to identify causes of hypoxemia or dyspnoea, and to monitor patients with interstitial lung disease (3). DLCO is decreased in patients with emphysema due to a decrease in the total surface area of the lung and the loss of capillary beds (1,4). In contrast to the abundance of genome-wide association studies (GWAS) investigating genetic variation of spirometry measures (5)(6)(7)(8), the heritability of, and genetic influences on DLCO, are largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Heritability and genome-wide association study of diffusing capacity of the lung

Terzikhan

Sun

Verhamme

et al. 2018

Preprint

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Background: Although several genome wide association studies (GWAS) have investigated the genetics of pulmonary ventilatory function, little is known about the genetic factors that influence gas exchange. Aim: To investigate the heritability of, and genetic variants associated with the diffusing capacity of the lung. Methods: GWAS was performed on diffusing capacity, measured by carbon monoxide uptake (DLCO) and per alveolar volume (DLCO/VA) using the singlebreath technique, in 8,372 individuals from two population-based cohort studies, the Rotterdam Study and the Framingham Heart Study. Heritability was estimated in related (n=6,246) and unrelated (n=3,286) individuals. Results: Heritability of DLCO and DLCO/VA ranged between 23% and 28% in unrelated individuals and between 45% and 49% in related individuals. Meta-analysis identified a genetic variant in GPR126 that is significantly associated with DLCO/VA. Gene expression analysis of GPR126 in human lung tissue revealed a decreased expression in patients with COPD and subjects with decreased DLCO/VA. Conclusion: DLCO and DLCO/VA are heritable traits, with a considerable proportion of variance explained by genetics. A functional variant in GPR126 gene region was significantly associated with DLCO/VA. Pulmonary GPR126 expression was decreased in patients with COPD.

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The Importance of the Assessment of Pulmonary Function in COPD

Cited by 46 publications

References 18 publications

Pulmonary Function Parameters in High-resolution Computed Tomography Phenotypes of Chronic Obstructive Pulmonary Disease

Pulmonary Function Parameters in High-resolution Computed Tomography Phenotypes of Chronic Obstructive Pulmonary Disease

Spirometric indices in primary ciliary dyskinesia: systematic review and meta-analysis

Heritability and genome-wide association study of diffusing capacity of the lung

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